Tumor suppressor gene CYLD is a deubiquitinating enzyme which negatively regulates various signaling pathways by removing the lysine 63-linked polyubiquitin chains from several specific substrates. Loss of CYLD in different types of tumors leads to either cell survival or proliferation. In this study we demonstrate that lack of CYLD expression in CYLD-/- MEFs increases proliferation rate of these

The article investigates the perception of death in eighteenth century European Freemasonry.

Treatment with IgG against the malondialdehyde (MDA)-modified apolipoprotein B-100 epitope p45 reduces atherosclerosis in experimental models. This study investigated the association between p45 IgG autoantibodies and plaque inflammation in subjects with advanced cardiovascular disease.

Three patients with a failed total ankle arthroplasty underwent tibiocalcaneal arthrodesis. In an attempt to preserve leg length, a titanium cage filled with autologous bone was placed in the defect. None of the ankles healed primarily. After 9 to 29 months, the cages, which only contained necrotic material, were removed and repeat arthrodesis was performed using a retrograde intramedullary nail.

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Monitoring constitutes a cornerstone, both for efficient control of optimized industrial processes and for obtaining knowledge about non-controlled, natural phenomena. This thesis is all about monitoring, or measurements. In this case the primary information is gathered with light, and in a non-intrusive, and usually a stand-off or remote way. The applications of optical monitoring in this work

Krönika om begreppet kultfilm, de ursprungliga filmerna som samlades under begreppet på 1970-talet jämfört med 2000-talets självmedvetna produktioner.

A delay in surgery due to laboratory abnormalities may increase mortality in patients with hip fracture. In order to optimize the logistics for urgent surgery in patients with hip fractures and anti-vitamin K treatment, individualized doses of a Prothrombin Concentrate were guided by a bedside whole blood prothrombin time test. Thirty patients with emergency hip fracture and preoperative anti-vit

PURPOSE: This study aimed to determine if there are any associations between serum levels of inflammatory markers and proliferative retinopathy (PDR) in type 1 diabetic patients. DESIGN: A cross-sectional design was utilized for this study. METHODS: One hundred twenty-eight type 1 diabetic patients underwent stereo fundus photography according to the Early Treatment Diabetic Retinopathy Study and

Cash Flow-at-Risk (CFaR) is a risk measure that conveys information on the shortfall in cash flow, associated with a certain probability, a firm could experience over a certain time period. However, to provide information on outcomes that are identified as costly by the risk management literature, in particular underinvestment due to financing constraints, a risk measure needs to make explicit ref

Objective: A prospective evaluation of the long-term effects of early menopause on mortality, risk of fragility fracture and osteoporosis. Design: Prospective population-based observational study. Setting Malmö, Sweden. Population A total of 390 white north European women aged 48 years at the start of the study. Methods: At baseline, bone mineral density (BMD) was measured by single-photon abs

Abstract Conclusion: In this physiological study subjects with Meniere's disease (MD) had high resistance to opening of the eustachian tube (ET) in three of four provocation tests. These subjects can be exposed to pressure deviations in the middle ear (ME) above their equalizing capacity. Transmission of the pressure deviations to the inner ear fluids and influence of the symptoms of MD are feasib