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Popular Abstract in Swedish Vårt immunsystem har utvecklats för att skydda våra vävnader och organ vid infektioner, cancerväxt och andra skador. Immunsystemet utgörs av en mängd olika celltyper som på olika sätt specifikt, främst genom uttryck av receptorer på cellytan, reagerar på främmande strukturer, från t ex patogener eller tumör celler eller andra substanser som signalerar stress eller fara.This thesis is based on three original papers with the overall aim to study the mechanisms of induction and function of Foxp3+CD4+CD25+ regulatory T cells. Regulatory T cells induce down-modulation of costimulatory molecules CD80 and CD86 on dendritic cells in vitro. In the first study we further show that the extent of down-modulation is functionally significant since regulatory T cell condition

This thesis explores women’s access to property in Kenya. It consists of three parts. The first gives the Kenyan background, the theoretical and methodological approach. The second presents the findings in relation to the social construct of the gender and elaborates them in the contexts of women´s subsistence work, colonization and its aftermath and women´s formation of organizations. The third p

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A new type of liposomal liver-specific contrast medium was studied in an experimental tumour model. Rabbits were inoculated with VX2-carcinoma directly in the liver of laparotomy. CT studies were carried out 14 days after inoculation. The liver-specific contrast medium consisted of a suspension of liposomes in a 100 mg I/ml iodixanol solution, with equal amounts of encapsulated and nonencapsulated

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Objective. Our purpose was to determine normative data for maternal cerebral blood flow indices. Study design. A prospective longitudinal study. Methods. The maternal middle cerebral artery was examined by transcranial Doppler ultrasound in 14 healthy women before (0-10 months prior to conception) and during pregnancy ( at 8, 15, 22, 29, and 36 weeks of gestation), and twice after delivery ( at 8

The spectrum of Eta Carinae and its ejecta shows slow variations over a period of 5.5 years. However, the spectrum changes drastically on a time scale of days once every period called the "spectral event". We report on variations in the narrow emission line spectrum of gas condensations (the Weigelt blobs) close to the central star during a spectral event. The rapid changes in the stellar radiatio

We study the Hausdorff dimension of a large class of sets in the real line defined in terms of the distribution of frequencies of digits for the representation in some integer base. In particular, our results unify and extend classical work of Borel, Besicovitch, Eggleston, and Billingsley in several directions. Our methods are based on recent results concerning the multifractal analysis of dynami

BACKGROUND: Asthma-like symptoms, methacholine hyperresponsiveness, use of inhaled steroids, airway inflammation, and increased tenascin expression in the reticular basement membrane have been reported in competitive cross-country skiers. OBJECTIVE: To investigate the effect of inhaled budesonide, 400 mug twice daily, on indices of airway inflammation in 'ski asthma', defined as asthma-like sympto

Common bacterial pathogens are becoming progressively more resistant to traditional antibiotics, representing a major public-health crisis. Therefore, there is a need for a variety of antibiotics with alternative modes of action. In our study, several nucleoside analogs were tested against pathogenic staphylococci and streptococci. We show that pyrimidine-based nucleoside analogs, like 3'-azido-3'