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Objective: Severe obesity poses a major public health concern due to its links with cardiometabolic complications and mortality. Visceral adipose tissue (VAT) plays a key role in these processes through distinct molecular features. This study aimed to characterize the VAT proteome of individuals with severe obesity and investigate its association with serum metabolic biomarkers. Methods: A cross-s

Background: Fine-needle aspiration biopsy (FNAB) of lymph nodes is a widely used method for evaluating lymphadenopathy. FNAB offers general advantages of rapid turnaround time, low cost and minimal morbidity, and more specific advantages in various clinical situations, such as deeply located lymph nodes or patients with significant comorbidities. The FNAB sample can be utilized for a wide range of

Background: Low lung function has been consistently associated with increased cardiovascular disease (CVD) risk, with emerging evidence suggesting a potential causal relationship. However, underlying biological mechanisms remain unclear. Aim: To investigate relationships between CVD-associated plasma proteins and lung function. Methods: We analysed plasma protein profiles in two Swedish population

The meeting between public life in the city and our private bodily needs creates sensitive and complex architectural challenges, and public toilets are a clear example. They are often seen as merely practical and technical spaces, but they also reveal how a city thinks about accessibility, safety, and equality. How can these places meet basic needs while still feeling safe, clean, and welcoming? A

In response to the environmental crisis and growing consumer awareness, increasing attention has been directed towards sustainable production models centred on circularity, resource efficiency, and reduced environmental impact. Against this background, practices such as upcycling, which aim to extend product lifespans and reduce waste, have gained increased attention. The European Union has artic

Den 1 juli 2025 infördes DNA-baserad släktforskning som ett polisiärt utredningsverktyg i Sverige. Metoden kallas även utredande genetisk genealogi och har hyllats som en ”kriminalteknisk revolution” och beskrivits i termer som ”genombrott”. Att inga uppklarade brott offentliggjorts och inga fällande domar meddelats sedan ikraftträdandet väcker däremot frågor om dess egentliga straffprocessuella bOn July 1, 2025, genetic genealogy was introduced as a tool for police investigations in Sweden. The method is also called investigative genetic genealogy and has been praised as a “forensic revolution” and described in terms such as “breakthrough”. However, the fact that no solved crimes have been made public and no convictions have been issued since its commencement raises questions regarding it

Denna uppsats undersöker huruvida nuvarande kontrollåtgärder gällande efterlevnaden av kollektivavtal är tillräckligt effektiva, samt hur eventuella ytterligare kontrollåtgärder skulle påverka den bristande efterlevnaden av kollektivavtal samt den svenska modellen. Syftet med uppsatsen är att undersöka möjligheter och begränsningar knutna till befintliga och föreslagna kontrollåtgärder gällande eThis thesis examines whether current control measures regarding compliance with collective agreements are sufficiently effective, and how any additional control measures would affect the lack of compliance with collective agree ments and the Swedish model. The purpose of the thesis is to examine the possibilities and limitations associated with existing and proposed control measures regarding comp

The continued reliance on cars presents a challenge for sustainable mobility policy. A wide range of approaches exists to address this issue, from promoting more sustainable vehicle options to replacing cars altogether. However, national sustainable mobility policies related to car use often suffer from spatial blindness–which implies a limited contextual differentiation based on the specific char

Chemical vapour deposition enables large-domain growth of ideal graphene, yet many applications of graphene require the controlled inclusion of specific defects. We present a one-step chemical vapour deposition procedure aimed at retaining the precursor topology when incorporated into the grown carbonaceous film. When azupyrene, the molecular analogue of the Stone-Wales defect in graphene, is used

IMPORTANCE COVID-19 can lead to long-term cardiopulmonary symptoms and is associated with coronary microvascular dysfunction (CMD). However, long-term data on CMD after severe COVID-19 are lacking. OBJECTIVE To investigate long-term left ventricular function and the presence of CMD after severe COVID-19. DESIGN, SETTING, AND PARTICIPANTS This case-control study was conducted among patients at a si

Background Although the role of smoking as a risk factor for emphysema in α1-antitrypsin deficiency (AATD) is well known, never-smokers with severe AATD may also develop lung disease, ranging from mild asymptomatic disease to severe emphysema. Methods We performed a cross-sectional and observational study to analyse the characteristics of the population of never-smoker severe AATD (genotype) indiv

Background: Despite recommendations by EU, surveillance of Lyme neuroborreliosis (LNB) is still not fully implemented in all member states, Sweden being one of them. Laboratory-based notifications on positive Borrelia antibody index (AI) in paired cerebrospinal fluid-serum samples alone have been suggested for surveillance of LNB. Objectives: We aim to describe the epidemiology of Lyme borreliosis

Background: Transcatheter aortic valve replacement (TAVR) is increasingly used in patients with bicuspid aortic valve (BAV) stenosis, but there is limited comparative data on balloon-expandable (BEV) versus self-expanding valves (SEV) in this population. Aim: To compare clinical and hemodynamic outcomes between BEVs and SEVs in patients with BAV stenosis. Methods: This observational cohort include

Stiffening of tissue is a hallmark of cancer progression, promoting invasive phenotypes through altered cell-extracellular matrix (ECM) interactions. However, how fully formed epithelial structures respond to mechanical cues within their native ECM environment remains poorly understood. Here, using a 3D in situ stiffening hydrogel system that enables modulation of stiffness around mature normal ma

Background: People with intellectual disabilities experience significant health inequities. Digital interventions for health promotion are rarely designed from their specific needs. This study aimed to uncover core qualities of digital interventions for health promotion by exploring factors influencing health behaviours amongst people with intellectual disabilities. Methods: This study was conduct

Purpose – Our research examines the impact of Islamic religiosity, exploring the role of religious actors, religious ideas (knowledge-based religiosity) and religious practice, on the involvement in early-stage entrepreneurial activity at the provincial level in Indonesia. Design/methodology/approach – We rely on the survey conducted by Global Entrepreneurship Monitoring in Indonesia, spanning fro

This study presents a detailed simulation-based analysis of the detection limits of multi-element monolithic Germanium (Ge) detectors to cadmium traces in environmental soil samples. Using the capabilities of the Geant4 Monte Carlo toolkit in combination with the Solid State Detector Package, we evaluated the detection limit variation with the sample-to-detector distances and photon flux. These si

INTRODUCTION: The rapid digitalisation of workplaces presents both challenges and opportunities for older workers. This scoping review examines how digital technologies impact social support for older workers, focusing on emotional, informational, and instrumental support within professional environments. While social support is critical for well-being and productivity in ageing workforces, the ef

Objectives: This study aimed to assess the relationship between dietary intake and disease outcomes in patients with radiographic axial spondyloarthritis (r-axSpA), focusing on inflammation and disease activity, while also evaluating other health outcomes, and to compare dietary intake between patients and controls. Method: In a cross-sectional analysis, we studied 295 patients with r-axSpA (modif