Popular Abstract in Swedish Parkinsons sjukdom är en av våra mest förekommande neurologiska sjukdomar som drabbar den åldrande befolkningen. I åldersgruppen 50-60 år drabbas ca 1 procent av sjukdomen, som karakteriseras av de motoriska symptomen stelhet, långsamma rörelser och skakningar. Symptomen beror på en gradvis förlust av nervceller i en djup del av hjärnan vid namn substantia nigra (den svL-DOPA pharmacotherapy in Parkinson’s disease (PD) is associated with adverse effects occurring after a few years of treatment. Among these, dyskinesia (abnormal involuntary movements) is particularly common and potentially disabling. The causes behind dyskinesia are not completely understood, but intense research has identified a number of neuronal alterations associated with L-DOPA-induced dyski

Popular Abstract in Swedish Bröstcancer är den typ av cancer som drabbar flest kvinnor i Sverige. Årligen diagnostiseras drygt 7000 kvinnor med bröstcancer och ungefär 1400 dör av sin sjukdom. För att minska bröstcancerdödligheten rekommenderar Socialstyrelsen mammografiscreening där kvinnor över 40 år bjuds in för regelbundna kontroller. Dessa kontroller utförs med digital mammografi som innebär Breast cancer is the most common form of cancer affecting women in the western countries. Today x-ray digital mammography (DM) of the breast is commonly used for early detection of breast cancer. However, the sensitivity of mammography is limited, mainly due to the fact that a 3D volume is projected down to a 2D image. This problem can be partially solved by a tomographic technique. Breast tomosyn

This study investigates the sensitivity of wastewater treatment plant (WWTP) model performance to the selection of one-dimensional secondary settling tanks (1-D SST) models with first-order and second-order mathematical structures. We performed a global sensitivity analysis (GSA) on the benchmark simulation model No. 2 with the input uncertainty associated to the biokinetic parameters in the activ

Male-female differences may significantly impact stroke prevention and treatment in men and women, however underlying mechanisms for sexual dimorphism in stroke are not understood. We previously found in males that cerebral ischemia upregulates contractile receptors in cerebral arteries, which is associated with lower blood flow. The present study investigates if cerebral arteries from men and wom

In this work, the syntheses, structure, superoxide dismutase (SOD) activity, and the catalytic use in the oxidative transformations of cyclohexene of covalently grafted Fe(III)-complexes formed with various or various combinations of C-protected amino acid (l-histidine, l-tyrosine, l-cysteine and l-cystine) ligands are presented. The structural features of the surface complexes were studied by XAN

This paper tests the expectation hypothesis by using the volatility index VIX and the futures written on that index. Because the VIX index is negatively correlated with the S&P 500 index returns the VIX futures price should contain a negative risk premium, which we do confirm in this study. When the futures price is not adjusted with the risk premium, the expectation hypothesis is rejected at

We have carried out muon spin relaxation (mu SR), neutron diffraction, and inelastic neutron scattering (INS) investigations on polycrystalline samples of Ce(Ru1-xFex)(2)Al-10 (x = 0, 0.3, 0.5, 0.8, and 1) to investigate the nature of the ground state (magnetic ordered versus paramagnetic) and the origin of the spin-gap formation as evident from the bulk measurements in the end members. Our zero-f

Aim To describe nurses' perceptions of conditions for patient education, focusing on organisational, environmental and professional cooperation aspects, and to determine any differences between primary, municipal and hospital care. Background Although patient education is an important part of daily nursing practice, the conditions for this work are unclear and require clarification. Method A strat

The serum immunoglobulin-free light chain (FLC) assay measures levels of free kappa and lambda immunoglobulin light chains. There are three major indications for the FLC assay in the evaluation and management of multiple myeloma and related plasma cell disorders (PCD). In the context of screening, the serum FLC assay in combination with serum protein electrophoresis (PEL) and immunofixation yields

The article deals with the absence of women in school-books about history.

By combining a large-scale experimental assessment on timing of insect emergence with long-term monitoring of waterfowl hatching date, we here show that insect emergence is mainly driven by temperature, whereas there is only a weak effect of increasing spring temperatures on inter-annual variability in observations of waterfowl chicks. Hence, a change in timing of the mass-emergence of insects fro

Purpose – This study has three broad objectives: (1) to explore consumer views on different dimensions of consumer packaging when it comes to a common staple food; (2) to discuss the role of different packaging features in consumer choice; (3) to compare consumer views on purchasing a common staple food either as an undifferentiated anonymous commodity or as a differentiated product.Design/methodo

Myeloid-related proteins (MRPs) 8 and 14 are cytosolic proteins secreted from myeloid cells as proinflammatory mediators. Currently, the functional role of circulating extracellular MRP8/14 is unclear. Our present study identifies extracellular MRP8/14 as an autocrine player in the leukocyte adhesion cascade. We show that E-selectin-PSGL-1 interaction during neutrophil rolling triggers Mrp8/14 sec

Popular Abstract in Swedish Många forskningsprojekt inom materialvetenskap, medicin eller grundläggande fysik kräver smala strålar av laddade partiklar som fungerar som provtagare för att undersöka materiens egenskaper. Dessa partiklar kan vara protoner, elektroner lättare joner. Relativt ofta, behöver de accelereras nästan upp till ljusets hastighet för att kunna tränga in tillräckligt djupt i prLaser-driven particle acceleration makes use of sub-picosecond, pulsed, high-power laser systems, capable of producing intensities ~10^{19} W/cm^2 at the laser focus to form plasmas, and use ultra-relativistic and nonlinear dynamics to produce quasistatic acceleration fields. This allows electrons to be accelerated to ~100 MeV over sub-centimetre distances, while protons may be accelerated to the

Recension av bok om mottagandet av fångar från koncentrationsläger som kom till Sverige våren 1945.

Parkinson’s disease (PD) is a progressive neurodegenerative disorder, characterized by tremor, muscle rigidity and bradykinesia, which is primarily due to the degeneration of nigrostriatal dopaminergic neurons. Currently, patients are primarily treated with L-dopa and other drugs that enhance dopaminergic function. Those are effective during the first years, but eventually the majority of patients

Atherosclerosis, thickening of the major arteries, is a chronic disease leading to cardiovascular disease (CVD) such as myocardial infarction (MI) and stroke, both affecting millions worldwide. T-cells and antibodies have been implicated in atherosclerosis. This thesis contains studies on CD4+ helper subsets and studies on antibodies against methylglyoxal-modified apolipoprotein B100 (MGO-ApoB100)

We present results from stopped beam rare isotope spectroscopic investigations at the GSI (RISING) experiment based on the detection of gamma-ray transitions following the beta decay of Pd-94. A comparison between the measured low-lying level scheme of Rh-94 and the prediction from shell-model calculations reveals the important roles of the g(7/2) and g(9/2) orbitals in explaining the structural f

Thin metallic nanowires are highly promising candidates for plasmonic waveguides in photonic and electronic devices. We have observed that light from the end of a silver nanowire, following excitation of plasmons at the other end of the wire, is emitted in a cone of angles peaking at nominally 45-60 degrees from the nanowire axis, with virtually no light emitted along the direction of the nanowire