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The wheel-rail system operates in an open environment where the weather condition varies constantly. In this laboratory study, an investigation using a pin-on-disc tribometer placed in a temperature-controlled room was conducted to examine the effect of subzero temperature and snow on friction and wear at the wheel-rail contact. In temperature range from 3 to-15 °C (without snow) friction and wear

AbstractBackground: Non-communicable diseases are the number one killer worldwide and the leading one,cardiovascular disease (CVD), is responsible for more than 30% of all deaths. CVD is a progressive disease whichalso makes it economical, easy and effective to prevent. There are many stages of CVD that ultimately can lead tocoronary atherosclerosis, measurable as coronary artery calcification (CA

Traditional analyses of 1 Cor 14:20–25 have not been able to solve the interpretational problems, especially the crux interpretum of v. 22b. Since the problem is one of argumentation it is natural to seek assistance from a method of argumentation analysis. By making use of the method by Stephen Toulmin, it can be shown that the argument may contain more information than is directly apparent. By re

Gal 3:6–14 är ett av många avsnitt i Paulus brev som är svårt att förstå p.g.a. den komplicerade argumentationen. En argumentationsanalys är därför påkallad för att reda ut argumenten och för att klargöra eventuella implicita premisser. En sådan analys ger oss en bättre uppfattning av Paulus argumentation än en traditionell exeges ensam kan ge. Analysen ger vid handen att Paulus försöker övertyga

Through an argumentation analysis can one show how it is feasible to view a narrative religious text such as the Gospel of Matthew as a literary argument. The Gospel is not just “good news” but an elaborate argument for the standpoint that Jesus is the Son of God, the Messiah. It is shown why an argumentation analysis needs to be supplemented with a pragmatic literary analysis in order to describeThrough an argumentation analysis can one show how it is feasible to view a narrative religious text such as the Gospel of Matthew as a literary argument. The Gospel is not just “good news” but an elaborate argument for the standpoint that Jesus is the Son of God, the Messiah. It is shown why an argumentation analysis needs to be supplemented with a pragmatic literary analysis in order to describe

The article analyses techniques of verbal rhetoric based on recordings of prayer meetings from the first year of the Nokia Missio Church (2008–2009). The rhetorical situation is of particular interest in this charismatic congregation. The crowd can be examined from the viewpoint of the various participant groups, drawing on Lloyd Bitzer’s idea of the life span of a rhetorical situation. Classical

Even though the design of buildings and technologies have been mainly focused on reducing energy use, there is still a discrepancy between predicted and actual energy saving due to user behavior. There is a need of understanding the behavior and relevant factors of using energy-efficient solutions. Energy-efficient solutions in an indoor environment can be defined as building characteristics such

Clinical trials in neurodegenerative disorders have been associated with high rate of failures, while in oncology, the implementation of precision medicine and focus on genetically defined subtypes of disease and targets for drug development have seen an unprecedented success. With more than 20 genes associated with Parkinson’s disease (PD), most of which are highly penetrant and often cause early

Tuning the anisotropy through exchange bias in bimagnetic nanoparticles is an active research strategy for enhancing and tailoring the magnetic properties for a wide range of applications. Here we present a structural and magnetic characterization of unique FeCr-oxide nanoparticles generated from seed material with a Fe : Cr ratio of 4.71 : 1 using a physical aerosol method based on spark ablation

Background: Processing the surface electromyogram (sEMG) to decode movement intent is a promising approach for natural control of upper extremity prostheses. To this end, this paper introduces and evaluates a new framework which allows for simultaneous and proportional myoelectric control over multiple degrees of freedom (DoFs) in real-time. The framework uses multitask neural networks and domain-

Here, we highlight the potential translational benefits of delivering FLASH radiotherapy using ultra-high dose rates (>100 Gy·s−1). Compared with conventional dose-rate (CONV; 0.07–0.1 Gy·s−1) modalities, we showed that FLASH did not cause radiation-induced deficits in learning and memory in mice. Moreover, 6 months after exposure, CONV caused permanent alterations in neurocognitive end points, wh

Purpose: Preclinical studies using a new treatment modality called FLASH Radiotherapy (FLASH-RT) need a two-phase procedure to ensure minimal uncertainties in the delivered dose. The first phase requires a new investigation of the reference dosimetry lying outside the conventional metrology framework from national metrology institutes but necessary to obtain traceability, repeatability, and stabil

Introduction: Radiotherapy treatment planning is a multi-criteria problem. Any optimization of the process produces a set of mathematically optimal solutions. These optimal plans are considered mathematically equal, but they differ in terms of the trade-offs involved. Since the various objectives are conflicting, the choice of the best plan for treatment is dependent on the preferences of the radi

The National Cancer Institute's Radiation Research Program, in collaboration with the Radiosurgery Society, hosted a workshop called Understanding High-Dose, Ultra-High Dose Rate and Spatially Fractionated Radiotherapy on August 20 and 21, 2018 to bring together experts in experimental and clinical experience in these and related fields. Critically, the overall aims were to understand the biologic

Purpose: Ultra-high-dose-rate FLASH radiation therapy has been shown to minimize side effects of irradiation in various organs while keeping antitumor efficacy. This property, called the FLASH effect, has caused enthusiasm in the radiation oncology community because it opens opportunities for safe dose escalation and improved radiation therapy outcome. Here, we investigated the impact of ultra-hig

Purpose: Recent data have shown that single-fraction irradiation delivered to the whole brain in less than tenths of a second using FLASH radiotherapy (FLASH-RT), does not elicit neurocognitive deficits in mice. This observation has important clinical implications for the management of invasive and treatment-resistant brain tumors that involves relatively large irradiation volumes with high cytoto

When relativistic electrons are used to irradiate tissues, such as during FLASH pre-clinical irradiations, the electron beam energy is one of the critical parameters that determine the dose distribution. Moreover, during such irradiations, linear accelerators (linacs) usually operate with significant beam loading, where a small change in the accelerator output current can lead to beam energy reduc

Research efforts in FLASH radiotherapy have increased at an accelerated pace recently. FLASH radiotherapy involves ultra-high dose rates and has shown to reduce toxicity to normal tissue while maintaining tumor response in pre-clinical studies when compared to conventional dose rate radiotherapy. The goal of this review is to summarize the studies performed to-date with proton, electron, and heavy