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Financial Contracts in PIPE Offerings: The Role of Expert Placement Agents
We examine how Private Investment in Public Equity (PIPE) contracts allocate contingent cash flow rights between investors and issuers and the role of placement agents in PIPE contract design. Issuers advised by expert agents agree to more investor-friendly terms than issuers advised by nonexpert agents. Expert agents appear to help issuers understand the payoff consequences of negotiable terms. M
TIMP-1 and responsiveness of estrogen receptor negative breast cancer to preoperative epirubicin and cyclophosphamide with or without gefitinib
Acid-Base Speciation of Carboxylate Ions in the Surface Region of Aqueous Solutions in the Presence of Ammonium and Aminium Ions
The acid base speciation of surface-active carboxylate ions in the surface region of aqueous solutions was studied with synchrotron-radiation-based photoelectron spectroscopy. The protonated form was found at an extraordinarily large fraction compared to that expected from the bulk pH. When adding salts containing the weak acid NH4+ to the solution, the fraction of the acidic form at the surface i
Exploring nonverbal behavior in elite handball players: Development of the Handball Post-Shot Behavior Coding Scheme (H-PSB-CS)
It is hypothesized that nonverbal behaviors of team sport athletes have an important impact on the course of the game. However, quantitative research on this topic is rare, partly due to a lack of scientifically sound coding schemes developed to assess nonverbal behavior in team sports. The aim of the present study is to develop a coding scheme that measures nonverbal behaviors displayed by female
The Causative Classification of Stroke system An international reliability and optimization study
Background: Valid and reliable ischemic stroke subtype determination is crucial for well-powered multicenter studies. The Causative Classification of Stroke System (CCS, available at http://ccs.mgh.harvard.edu) is a computerized, evidence-based algorithm that provides both causative and phenotypic stroke subtypes in a rule-based manner. We determined whether CCS demonstrates high interrater reliab
Health-related quality of life is not impaired in children with undetected as well as diagnosed celiac disease: a large population based cross-sectional study
Background: Knowledge regarding the health-related quality of life (HRQoL) of children with celiac disease remains limited and inconclusive. We investigated the HRQoL of three groups of 12-year-olds with: i) undetected celiac disease ii) clinically diagnosed celiac disease, and iii) without celiac disease. Methods: A school-based cross-sectional multicenter screening study invited 18 325 children,
The effects of continuous prostacyclin infusion on regional blood flow and cerebral vasospasm following subarachnoid haemorrhage: study protocol for a randomised controlled trial
Background: One of the main causes of mortality and morbidity following subarachnoid haemorrhage (SAH) is the development of cerebral vasospasm, a frequent complication arising in the weeks after the initial bleeding. Despite extensive research, to date no effective treatment of vasospasm exists. Prostacyclin is a potent vasodilator and inhibitor of platelet aggregation. In vitro models have shown
Automatic Tuning of PID Controllers Based on Asymmetric Relay Feedback
This thesis presents an improved version of the classic relay autotuner. The proposed autotuner uses an asymmetric relay function to better excite the process in the experiment phase. The improved excitation provides the possibility to obtain better models and hence better tuning, without making the autotuner more complicated or time consuming.Some processes demand more accurate modeling and tunin
Two-pulse structured illumination imaging
Structured illumination (SI), which is an imaging technique that is employed in a variety of fields, permits unique possibilities to suppress unwanted signal contributions that carry misguiding information such as out-of-focus light or multiply scattered light. So far SI has been applied mostly for averaged imaging or for imaging of slowly occurring events because it requires three acquisitions (s
Overexpression of vascular endothelial growth factor C increases growth and alters the metastatic pattern of orthotopic PC-3 prostate tumors
Background: Prostate cancer metastasizes to regional lymph nodes and distant sites but the roles of lymphatic and hematogenous pathways in metastasis are not fully understood. Methods: We studied the roles of VEGF-C and VEGFR3 in prostate cancer metastasis by blocking VEGFR3 using intravenous adenovirus-delivered VEGFR3-Ig fusion protein (VEGFR3-Ig) and by ectopic expression of VEGF-C in PC-3 pros
Micellization of Water-Soluble Complex Salts of an Ionic Surfactant with Hairy Polymeric Counterions
For ionic surfactants in general, a change from simple to polymeric counterions leads to increasing attraction between micelles, condensing them in a concentrated phase. In the present study, two novel “complex salts” were prepared in which the cationic surfactant hexadecyltrimethylammonium was neutralized by two different copolyions, both having poly(methacrylate) main chains randomly decorated w
A mixing study in a double-Rushton stirred tank
Computational and experimental methods have been used to investigate the flow field, power and mixing time in a fully baffled stirred vessel with two six-blade Rushton turbines. Flow in a stirred tank involves interactions between flow around rotating impeller blades and stationary baffles. In computational fluid dynamics (CFD), the flow field was developed using the sliding mesh (SM) approach. Th
Modelling and optimisation of preparative chromatographic purification of europium.
A model commonly used to describe the separation of biomolecules was used to simulate the harsh environment when eluting neodymium, samarium, europium and gadolinium with a hot acid. After calibration, the model was used to optimise the preparative separation of europium, as this is the most valuable of the four elements. A kinetic dispersive model with a Langmuir mobile phase modulator isotherm w
MORTALITY AMONG MEN WITH LOCALLY ADVANCED PROSTATE CANCER MANAGED WITH NON-CURATIVE INTENT; A NATIONWIDE STUDY IN PCBASE SWEDEN
Remarks on features
This paper pursues the idea that uninterpretable features are not present in syntax, but are instead a product of the interfaces. In particular, it argues that formal feature values belong to PF only, i.e., that they are not syntactic objects but PF ‘translations’ of more abstract syntactic structures and correlations. It follows that case is nonexistent in syntax and it also follows that agreemen
Investigation of combustion enhancement by ozone additive in CH(4)/air flames using direct laminar burning velocity measurements and kinetic simulations
The effect of ozone additive on the enhancement of the burning velocity for premixed methane-air flames is investigated by both experimental measurements and kinetic simulations. Laminar burning velocities with and without O(3) were directly measured using the Heat Flux method. The O(3) molecules were introduced into the system by a dielectric-barrier-discharge ozone generator installed in the O(2
Measurement of the centrality dependence of J/psi yields and observation of Z production in lead-lead collisions with the ATLAS detector at the LHC
Using the ATLAS detector, a centrality-dependent suppression has been observed in the yield of J/psi mesons produced in the collisions of lead ions at the Large Hadron Collider. In a sample of minimum-bias lead-lead collisions at a nucleon-nucleon centre of mass energy root s(NN) = 2.76 TeV, corresponding to an integrated luminosity of about 6.7 mu b(-1), J/psi mesons are reconstructed via their d
The redox interaction between the vanadyl cation and tris[6-(2-hydroxymethyl)pyridylmethyl]amine
Reaction of tris[6-(2-hydroxymethyl)pyridylmethyl]amine, tpa(OH)(3), with (VOSO4)-O-IV center dot 5H(2)O resulted in an unexpected redox reaction producing [(VLH)-L-III][(VLH2)-L-III][PF6](3)center dot 1.5H(2)O (where H3L is bis(2-hydroxymethylpyridyl)(2-carboxypyridylmethyl)amine). This reaction is interesting in the light of the ability of ascidians to accumulate V-III by reduction of V-V from s
Harmonic morphisms from four-dimensional Lie groups
We consider 4-dimensional Lie groups with left-invariant Riemannian metrics. For such groups we classify left-invariant conformal foliations with minimal leaves of codimension 2. These foliations produce local complex-valued harmonic morphisms.