The tumour immune microenvironment (TIME) in breast cancer is acknowledged with an increasing role in treatment response and prognosis. With a growing number of immune markers analysed, digital image analysis may facilitate broader TIME understanding, even in single-plex IHC data. To facilitate analyses of the latter an open-source image analysis pipeline, Tissue microarray MArker Quantification (

In Sweden, phosphorus is commonly removed from municipal wastewater treatment by chemical precipitation (CP). Recently, such alternatives as enhanced biological phosphorus removal (EBPR) have garnered interest due to the increased risk of chemical shortage. In this study, a life cycle assessment (LCA) was performed to compare EBPR and CP in three scenarios: 1) baseline – precipitation chemicals av

Background: Given the national shortage of palliative care specialists relative to the need for their services, engaging nonspecialists is important to ensure patients with serious illness have an opportunity to share their goals and values with their providers. Hospital medicine clinicians are well positioned to conduct these conversations given they care for many medically complex patients. Yet,

BACKGROUND: We designed group coaching calls to reinforce communication skill acquisition and Serious Illness Care Program uptake in adult primary care.MEASURES: Percentage of primary care physicians (PCPs) who have documented a serious illness conversation in the electronic health record (EHR) approximately three and six months after the coaching intervention. Participant feedback surveys to bett

The ratio of production cross-sections of ψ(2S) over J/ψ mesons as a function of charged-particle multiplicity in proton-proton collisions at a centre-of-mass energy s = 13 TeV is measured with a data sample collected by the LHCb detector, corresponding to an integrated luminosity of 658 pb−1. The ratio is measured for both prompt and non-prompt ψ(2S) and J/ψ mesons. When there is an overlap betwe

Using a dataset corresponding to 9 fb−1 of integrated luminosity collected with the LHCb detector between 2011 and 2018 in proton-proton collisions, the decay-time distributions of the decay modes Bs 0→J/ψη′ and Bs 0→J/ψπ+π− are studied. The decay-width difference between the light and heavy mass eigenstates of the Bs 0 meson is measured to be ∆Γs = 0.087 ± 0.012 ± 0.009 ps−1, where the first unce

The covid-19 pandemic was characterized by a series of variants of concern, different strains of SARS-CoV-2 which had a serious impact on transmission. One of these, denoted Omicron, dominated in early 2022 and caused covid-19 cases to soar. The increased transmission during the Omicron wave triggered hospitals to further strengthen airborne precautions. The reason for this surge in cases during O

The cross-section of associated J/ψ-ψ(2S) production in proton-proton collisions at a centre-of-mass energy of (Formula presented.) TeV is measured using a data sample corresponding to an integrated luminosity of 4.2 fb−1, collected by the LHCb experiment. The measurement is performed for both J/ψ and ψ(2S) mesons having transverse momentum pT< 14 GeV/c and rapidity 2.0 < y < 4.5, assuming negligi

Emmer (1993) claimed creativity to be a bridge between art and mathematics exemplified (www. olats.org/colloque/textes/texte7.shtml) in his traveling exhibition The Eye of Horus: Art and Mathematics (Emmer, 1990). A shared language is needed to make bridges between science, art and metaphysics (Thiessen, 1998). Scientific phenomena and concepts need to be possible to isolate for better understandi