Background: RORγt is a transcription factor that enables elaboration of Th17-associated cytokines (including IL-17 and IL-22) and is proposed as a pharmacological target for severe asthma. Methods: IL-17 immunohistochemistry was performed in severe asthma bronchial biopsies (specificity confirmed with in situ hybridization). Primary human small airway epithelial cells in air liquid interface and p

According to an increasingly popular view known as non-doxasticism, religious faith need not include belief, but only some cognitively weaker attitude. This view comes with great promises, as it offers a way for the agnostic to partake in religion. My concern is how such a non-doxastic faith might be understood as a rational attitude. I offer three desiderata for any account of rational, non-doxas

As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–

Background: Being an informal carer of a person with dementia (PwD) can have a negative effect on the carer’s health and quality of life, and spouse carers have been found to be especially vulnerable. Yet relatively little is known about the care provided and support received by spouse carers. This study compares spouse carers to other informal carers of PwDs regarding their care provision, the su

The numerical simulation of the induction heating process can be computationally expensive, especially if ferromagnetic materials are studied. There are several analytical models that describe the electromagnetic phenomena. However, these are very limited by the geometry of the coil and the workpiece. Thus, the usual method for computing more complex systems is to use the finite element method to

Background: The aim of this study was to analyze overall survival in endometrial cancer patients’ FIGO stages I-III in relation to surgical approach; minimally invasive (MIS) or open surgery (laparotomy). Methods: A population-based retrospective study of 7275 endometrial cancer patients included in the Swedish Quality Registry for Gynecologic Cancer diagnosed from 2010 to 2018. Cox proportional h

Background: Mast cells (MCs) are known to contribute to both acute and chronic inflammation. Bronchial epithelial cells are the first line of defence against pathogens and a deficient anti-viral response has been suggested to play a role in the pathogenesis of asthma exacerbations. However, effects of MC mediators on bronchial epithelial immune response have been less studied. The aim of this stud

Denna rapport och studie är en pilotstudie som ska mynna ut i två förgreningar eller riktningar. En riktning går mot digital hållbarhet och den andra mot ett större projekt där målsättningen är att utveckla en modell för hur varumärken och företag bakom dessa ska förhålla sig till de 17 globala målen i sin marknadsföring med syfte att bli både hållbara och säljande – dvs hur ska företagen göra för

Immortalized erythroid cell lines are expected to be a promising source of ex vivo manufactured red blood cells (RBCs), however the induction of enucleation in these cell lines is inefficient at present. We utilized an imaging-based high-throughput system to identify chemical compounds that trigger enucleation of human erythroid cell lines. Among >3,300 compounds, we identified multiple histone de

Traumatic brain injury and stroke result in hemiplegia, hemiparesis, and asymmetry in posture. The effects are mostly contralateral; however, ipsilesional deficits may also develop. We here examined whether ablation brain injury and controlled cortical impact (CCI), a rat model of clinical focal traumatic brain injury, both centered over the left or right sensorimotor cortex, induced hindlimb post

Using grazing incidence X-rays and X-ray photoelectron spectroscopy during the mass transfer limited catalytic oxidation of CO, the long-range surface structure of Pd(100) was investigated. Under the reaction conditions of 50:4 O2 to CO, 300 mbar pressure, and temperatures between 200 and 450 °C, the surface structure resulting from oxidation and the subsequent oxide reduction was elucidated. The

In safety-critical systems, such as aviation systems, nuclear power plants and hospitals, system failures can cause loss of life, environmental and property damage. Safety-critical systems consists of loose or tight interactions, they are more or less complex, and these characteristics affect the system’s ability to prevent and overcome emerging system failures. The demand for good safety cultures

Rostrocaudal patterning of the neural tube is a defining event in vertebrate brain development. This process is driven by morphogen gradients which specify the fate of neural progenitor cells, leading to the partitioning of the tube. Although this is extensively studied experimentally, an integrated view of the genetic circuitry is lacking. Here, we present a minimal gene regulatory model for rost

Bakgrund Teknikutvecklingen inom hälso- och sjukvårdsområdet möjliggör ständigt nya och mer avancerade sätt att distansmonitorera och vårda patienter digitalt. Digitaliseringen inom hälso- och sjukvårdsområdet i form av till exempel hälsoapplikationer gör det möjligt för patienter och personal att ha kontakt och kommunicera digitalt med varandra (WHO, 2011). itACiH är ett digitalt system där patie

Bakgrund Framväxten av hälsoapplikationer som gör det möjligt för patienter att kontakta och kommunicera med vårdpersonal digitalt kan förändra hur patienter ser på sin vård och hur de kontaktar vårdpersonalen (WHO, 2011). Digitala system kan också, utifrån sin design, ge förutsättningar för relationscentrerad vård genom att patienterna ges möjlighet att, i samverkan med vårdpersonalen, vara aktiv

One of the most significant obstacles for the every­day use of systems based on Brain­Computer Inter­faces (BCIs) is the tediousness of calibration. Successful improvements on calibration, particularly the time needed and the user­experience, have been made with, e.g., transfer learning, gamification, and task estimation [1, 2, 3]. Inthis work, we present an adaptive approach to BCI systems’ calib

In this study we explore what digitally supported, mobile work in home care nursing may look like in practice. The results show that there is a large degree of self-determination among the nurses when it comes to organizing their work and that the digital systems can lead to an increased complexity. The diverse environment encountered in home care (as compared to the more standardized hospital env