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Toxin-antitoxin-chaperone (TAC) systems are three-part gene clusters encoding a toxin, antitoxin, and specialized SecB-like chaperone (SecB TA) with emerging roles in phage defense. To identify and classify SecB homologs and associated TACs across bacteria, we surveyed the full RefSeq database. Phylogenetic and gene neighborhood analyses reveal three major SecB subfamilies: two housekeeping groups
AIMS: Diagnosing heart failure with preserved ejection fraction (HFpEF) remains challenging, particularly in older individuals. We hypothesized that machine learning (ML) approaches could improve diagnostic accuracy compared with HFpEF scores.METHODS: We evaluated the diagnostic performance of four supervised ML algorithms (random forest [RF], extreme gradient boosting [XGBoost], support vector ma
Although much progress has been made over the last decades, there is still a significant clinical need for novel therapies to manage cancer. Typical problems are that solid tumors are frequently inaccessible, aggressive, and metastatic. To contribute to solving some of these issues, we have developed a novel radioisotope-labeled 27 nm nanoparticle, 177Lu-SN201, to selectively target solid tumors v
Obesity’s metabolic heterogeneity is not fully captured by body mass index (BMI). Here we show that deep multi-omics phenotyping of 1,408 individuals defines a metabolome-informed obesity metric (metBMI) that captures adipose tissue-related dysfunction across organ systems. In an external cohort (n = 466), metBMI explained 52% of BMI variance and more accurately reflected adiposity than other omic
The T-REX neutron spectrometer at the European Spallation Source will use Multi-Grid Technology, which is a voxelised proportional counter relying on 10B4C coatings to detect neutrons scattered by the sample under investigation. Measurements of the position dependence of pulse-height and relative detection efficiency of a Multi-Grid prototype of the T-REX spectrometer are presented for two differe
Temperature, a key environmental stressor, can induce changes at the molecular levels in the body of living beings, which are necessary for adaptation and survival under altered conditions. We investigated the effects of acute cold (3 °C) and heat (32 °C) shocks on hemolymph protein profiles in marbled crayfish. Results showed that cold shock induced a metabolic shift toward glucose production by
INTRODUCTION: Genetic deficiency of factor XI is associated with a reduced risk of ischemic stroke. Asundexian is a direct inhibitor of activated factor XIa (FXIa) with a low risk of bleeding in early trials. We seek to determine its efficacy and safety combined with antiplatelet therapy for prevention of ischemic stroke. PATIENTS AND METHODS: Oral faCtor Eleven A iNhibitor asundexian as novel ant
In parallel with the exponential increase in extractivism around the world, comes social movements resisting such processes and advocating for alternative forms of development. Extractivism - a mode of accumulation associated with capitalism - is problematic due to the socio-ecological destruction that is embedded in its logics. Opposition to extractivism has intensified and in many instances, wom
Volume 3 of the FCC Feasibility Report presents studies related to civil engineering, the development of a project implementation scenario, and environmental and sustainability aspects. The report details the iterative improvements made to the civil engineering concepts since 2018, taking into account subsurface conditions, accelerator and experiment requirements, and territorial considerations. I
Volume 1 of the FCC Feasibility Report presents an overview of the physics case, experimental programme, and detector concepts for the Future Circular Collider (FCC). This volume outlines how FCC would address some of the most profound open questions in particle physics, from precision studies of the Higgs and EW bosons and of the top quark, to the exploration of physics beyond the Standard Model.
Background: Cardiovascular diseases (CVDs) are the leading cause of mortality and are among the foremost causes of disability globally. CVD burden has continued to increase in most countries since 1990, with trends driven by changing exposures to harmful risk factors, population growth, and population aging. Objectives: We report estimates of global, national, and subnational CVD burden, including
As Nature Aging celebrates its fifth anniversary, the journal asks some of the researchers who contributed to the journal early on to reflect on the past and the future of aging and age-related disease research, the impact of the field on human health now and in the future, and what challenges need to be addressed to ensure sustained progress. © Springer Nature America, Inc. 2026.
Temperature variability and long-term warming are increasingly threatening agricultural sustainability in southern Rwanda, where smallholder farmers rely on climate-sensitive crops. However, comprehensive spatiotemporal assessments of temperature extremes and their impacts on agriculture remain limited. This study used daily minimum and maximum temperature data from 1983 to 2021 for Huye District,
The effect of periodate oxidation and borohydride reduction on arabinoxylan (AX) in aqueous solution was investigated using 13C NMR spectroscopy and small-angle X-ray scattering (SAXS). AX consists of a xylose backbone, which is mono- or di-substituted with arabinose. We show that at a ring-opening modification degree of 21%, periodate oxidation occurs predominantly on arabinose, and shows a prefe
Inverted perovskite solar cells (IPSCs) have emerged as promising photovoltaic technologies due to excellent photoelectric properties and solution processing advantages. However, the traditional preparation process based on inert atmosphere annealing of perovskite films faces key challenges, including high energy consumption, strict crystallization control, and the presence of stresses. The study
Background: Blood cultures (BCs) are key diagnostic elements for sepsis patients. Accurate preanalytical procedures are substantial, and results should be available as soon as possible to guide adequate antimicrobial treatment. This study aimed to evaluate BC collection practices and diagnostic capacity across European hospitals. Methods: This cross-sectional survey investigated BC diagnostics in
This paper examines the influence of the Efficient Markets Hypothesis (EMH) on financial regulation, using a perspective drawing on arguments from the Philosophy of Science discipline.The paper aims to show that, prior to the global financial crisis, there already existed a large body of empirically observed asset price anomalies, which may be seen to contradict the notion of elastic demand curves
Efficient and clean production of electrical and mechanical energy for use in industry, transportation and propulsion is currently a concern. The transition from fossil fuels to biofuels involves challenges related to the fuel composition and combustion, as well as methods to increase engine fuel flexibility. One potentially useful tool under development is Plasma Assisted Combustion (PAC), where
Background Advances in medical and surgical care have improved survival in patients with transposition of the great arteries (TGA), shifting focus toward quality of life (QoL). In this study we evaluate QoL in adults with TGA, including congenitally corrected TGA (ccTGA) and patients with dextro-TGA (d-TGA), by comparing patients with a systemic right ventricle (sRV) and systemic left ventricle (s
Renewable diesel fuels may reduce greenhouse gas emissions and particulate matter compared to fossil diesel, but the toxicity of their combustion products remains unclear. This study assessed pulmonary effects of renewable diesel exhaust particles in female C57BL/6NTac mice after single intratracheal instillation (6, 18, or 54 µg/mouse). Particles were generated from renewable fuels (rapeseed meth
