Conventional approaches to isolate and characterize nanobodies are laborious. We combine phage display, multivariate enrichment, next-generation sequencing, and a streamlined screening strategy to identify numerous anti-severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) nanobodies. We characterize their potency and specificity using neutralization assays and hydrogen/deuterium exchange m

Squamous-cell carcinoma of the anus (ASCC) is a rare disease. Barriers have been encountered to conduct clinical and translational research in this setting. Despite this, ASCC has been a prime example of collaboration amongst researchers. We performed a bibliometric analysis of ASCC-related literature of the last 20 years, exploring common patterns in research, tracking collaboration and identifyi

From 2014 to 2016, 44,617 unaccompanied refugee minors (URM) arrived and sought asylum in Sweden. Since their arrival, the Church of Sweden (CoS) has received hundreds of these young people seeking to join the church and be baptised as Christians. This phenomenon is notable in an institution that is otherwise declining in membership and which is not known for actively recruiting new members. While

Minimal residual disease (MRD) constitutes the most important prognostic factor in B-cell precursor acute lymphoblastic leukemia (BCP-ALL). Flow cytometry is widely used in MRD assessment, yet little is known regarding the effect of different immunophenotypic subsets on outcome. In this study of 200 BCP-ALL patients, we found that a CD34-positive, CD38 dim-positive, nTdT dim-positive immunophenoty

Background: Half the children with high-risk neuroblastoma die with widespread metastases. Molecular radiotherapy is an attractive systemic treatment for this relatively radiosensitive tumor. 131I-mIBG is the most widely used form in current use, but is not universally effective. Clinical trials of 177Lutetium DOTATATE have so far had disappointing results, possibly because the administered activi

English is widely recognized as the language of science, and English-language publications (ELPs) are rapidly increasing. It is often assumed that the number of non-ELPs is decreasing. This assumption contributes to the underuse of non-ELPs in conservation science, practice, and policy, especially at the international level. However, the number of conservation articles published in different langu

As 5G is entering maturity, the research interest has shifted towards 6G, and specially the new use cases that the future telecommunication infrastructure needs to support. These new use cases encompass much higher requirements, specifically: higher communication data-rates, larger number of users, higher accuracy in localization, possibility to wirelessly charge devices, among others.The radio ac

Context: The European Association of Urology (EAU) Renal Cell Carcinoma (RCC) Guideline Panel has prepared evidence-based guidelines and recommendations for the management of RCC. Objective: To present a summary of the 2022 RCC guideline, which is based on a standardised methodology including systematic reviews (SRs) and provides transparent and reliable evidence for the management of RCC. Evidenc

Objective: To develop a standardized sonographic evaluation and reporting system for Cesarean scar pregnancy (CSP) in the first trimester, for use by both general gynecology and expert clinics. Methods: A modified Delphi procedure was carried out, in which 28 international experts in obstetric and gynecological ultrasonography were invited to participate. Extensive experience in the use of ultraso

HYPOTHESIS: Self-assembling molecular structures responding to light stimulus are appealing for applications as sensing and drug delivery. Supramolecular nanotubes have a relevant potential in nanotechnology as they can be used to encapsulate different loads like drugs, biological macromolecules, and nanomaterials. In addition, they are suitable elements for novel supracolloidal materials. Structu

Although the overall mortality in cancer is steadily decreasing, major groups of patients still respond poorly to available treatments. The key clinical challenge addressed in the present thesis work relates to the inherent adaptive capacity of glioblastoma (GBM) tumors, resulting in treatment resistance and dismal prognosis. GBM represents the most common and lethal primary CNS tumor in adults. T

Stability problems associated with robot control with obstacle avoidance are analysed. Obstacle avoidance algorithms based on potential function are revised to accomplish stable re-design. A stability proof using Lyapunov theory and passivity theory is provided for the re-designed obstacle avoidance algorithm. The paper presents a modification of potential functions for obstacle avoidance aiming t

The impact of climate change on the deterioration of reinforced concrete elements have been frequently highlighted as worthy of investigation. This article addresses this important issue by presenting a time-variant reliability analysis to assess the effect of climate change on four limit states; the probabilities of corrosion initiation, crack initiation, severe cracking, and failure of a simply

Research suggests that until recently families in history could only avoid episodes of poverty if they put money aside. By helping to smooth consumption over the family life cycle, finance could prevent impoverishment, and is also likely to have had an effect on family life. Saving may have influenced cohabitation structures and the timing and incidence of birth, marriage, and death. That families

Cities across the world are increasingly labelling themselves as smart in one way or another. At the same time, this smartness appears amorphous or invisible in its built urban environment. Critical researchers writing on the smart city regularly express confusion or exasperation about precisely the difficulty to locate the smart in the city. Visibility of the smart city is not a given. This artic

Hur hänger Aktie-SM 1979 ihop med nyliberalismens framväxt i Sverige? Vilken roll spelade kokainet för Sigmund Freuds syn på normalitet? Hur har månen påverkat människan genom historien? Vad fick Mary Wollstonecraft att på resa genom ett kargt Norden omvärdera sin syn på revolutioner? Och vad kan en hästslaktare i 1800-talets Stockholm säga oss om människans paradoxala förhållande till djuren?Bild

Worldwide, and especially in Western civilizations, most of the staple diets contain high amounts of fat and refined carbohydrates, leading to an increasing number of obese individuals. In addition to inducing metabolic disorders, energy dense food intake has been suggested to impair brain functions such as cognition and mood control. Here we demonstrate an impaired memory function already 3 days

Det här dokumentet ger lokala politiker och tjänstemän ett processorienterat verktyg för att stärka förankringen (integreringen) av ekosystembaserad klimatanpassning i relevanta sektorer av kommunal verksamhet. Guiden presenterar systematiskt de nivåer och områden där förankring av ekosystembaserad klimatanpassning är viktigt, och möjliggör på så sätt planering och bedömning av åtgärder. Det övergThis guideline offers local government officers and local politicians process‐oriented assistance for integrating ecosystem‐based adaptation within relevant sectors of municipal administration with the aim of fostering sustainable urban development. It is thus an instrument to support leadership of this integration process. The levels and areas where integration of ecosystem‐based adaptation isrel

I denna forskningsöversikt kartläggs svenskproducerad och kvalitetsgranskad forskning om svensk forskarutbildning i syfte att illustrera forskningsfältets fysiska och vetenskapliga formering 2000–2020. Databasen Swepub användes för att identifiera licentiatavhandlingar, doktorsavhandlingar och refereegranskade artiklar som sedan analyserades med deskriptiv statistik och tematisk analys. Fältets fyIn this scoping review we map Swedish research on Swedish doctoral education in order to illustrate the physical and scientific configuration of the field from 2000 to 2020. The database Swepub was used to identify licentiate theses, doctoral theses, and peer reviewed articles. Subsequently the material was analysed through descriptive statistics and thematic analysis. The physical configuration o