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A multi-ancestry genome-wide association study of umbilical cord insulin and c-peptide levels will form the basis of an important future bioresource

Aims: Fetal insulin is a key regulator of fetal growth and the major contributor to high birth weight in pregnancies with maternal diabetes. There is evidence for genetic variation in regulating fetal insulin, but this has not been studied on a large-scale. We performed a genome-wide association study (GWAS) of umbilical cord insulin and c-peptide measurements to identify genetic variants associat

Hunting for Hollanders : The community responsibility system, trade sanctions, and public debt in the late-medieval Low Countries

To persuade creditors to lend, cities in the Low Countries relied on a community responsibility system that made all citizens personally liable for public debt. This exposed itinerant citizens to significant risks: their merchandise could be confiscated by creditors, and they could even be imprisoned for debt. Although it is usually difficult to assess how such sanctions were enforced in practice,

Scalable D-band antenna with coplanar and stacked parasitic elements for low-cost antenna-in-package

The unquenchable thirst for bandwidth to support next-generation wireless systems is increasingly bringing D-band into the spotlight. This work proposes a scalable D-band patch antenna that features both coplanar and stacked parasitic patch structures. By leveraging inter-patch coupling, different coplanar parasitic elements are excited across different frequency bands, enabling multi-mode operati

Design of low-cost sub-THz antennas for distributed deployment in 6G

Although 6G is not only about higher data rates, its envisioned peak data rate of 1 terabits per second requires larger frequency bandwidth than what 5G millimeter wave bands offer. Therefore, new frequency bands have been allocated in the sub-THz range for 6G applications. This paper reviews the concept of distributed deployment to provide coverage in sub-THz bands, focusing on the design and imp

Bottom up ethics: Neuroenhancement in education and employment

Neuroenhancement involves the use of neurotechnologies to improve cognitive, affective or behavioural functioning, where these are not judged to be clinically impaired. Questions about enhancement have become one of the key topics of neuroethics over the past decade. The current study draws on in-depth public engagement activities in ten European countries giving a bottom-up perspective on the eth

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In de Urgenda-uitspraak oordeelde de rechtbank dat de Staat minimaal 25-reductie in 2020 (t.o.v. 1990) moet nastreven. Dit reductiedoel is ambitieuzer dan de Europese CO2-reductiedoelstellingen. Een aantal auteurs meent daarom dat de uitspraak mogelijk strijdig is met het EU-recht en dat hierover een prejudiciële vraag gesteld had moeten worden. Deze opvatting wordt door auteurs betwist. Ten eerst