Several studies have revealed links between hypoxia and activation of Notch in solid tumors. While most reports have focused on icN1 stabilization by direct interaction with HIF proteins, little attention has been given to Notch ligand regulation during hypoxia. Here we show that the Notch ligand JAG2 is transcriptionally activated by hypoxia in a HIF-1α dependent manner. Hypoxic JAG2 induction re

Popular Abstract in Swedish Parkinsons sjukdom är en av våra vanligaste ålderssjukdomar i Sverige och drabbar en procent av befolkningen över 50 år. De karaktäristiska symptomen: skakningar, långsamma rörelser och stelhet orsakas i huvudsak av en förlust av nervceller som producerar signalsubstansen dopamin i hjärnan. Den mest effektiva behandlingen är L-DOPA, som i hjärnan omvandlas till dopamin.Parkinson's disease and L-DOPA-induced dyskinesia (LID) does not merely involve the dopamine (DA) system but also include non-dopaminergic systems such as glutamate and serotonin (5-HT). An aberrant glutamate transmission at the corticostriatal synapse, has been linked to LID. Pharmacological agents to glutamate receptors at this synapse, (of which some are already clinically tested), could preve

Reduced, stoichiometric and oxidized TiO2(110) surfaces have been compared using valence photoelectron spectroscopy. The results show that the intensity from the band-gap state carries contributions from both oxygen surface vacancies and residual Ti interstitials, present after the sample cleaning procedure. The density of Ti interstitials was found to be 0.05 +/- 0.02 monlayers (ML), while the de

1. Geolocation by light allows for tracking animal movements, based on measurements of light intensity over time by a data-logging device (geolocator). Recent developments of ultra-light devices (

Understanding the spatiotemporal distribution of birds is crucial for effective management and conservation of their populations. However, we still have only limited knowledge not only of the wintering destinations of many Iberian breeding migrants but also of aspects as general as the migratory behaviour of the populations of many common avian species that breed in the Iberian highlands. We used

Popular Abstract in Danish Med udgangspunkt i et kompetenceudviklingsprojekt for lærere i en svensk kommune adresserer denne afhandling de stigende krav til forandring og innovation, der karakteriserer den offentlige sektor generelt. Ved at følge kompetenceudviklingsprojektet gennem en fire-årig periode sættes projektet i en kontekst af innovation, globalisering og forandring. Forfatteren argumentThis dissertation critically analyses the discourse on educational change. By placing educational change in the context of globalisation and innovation the author argues that the current discourse on educational change is un-nuanced and omits the important perspectives on change. The author has analysed an educational district in Sweden and one of its projects on competence development, named 'Str

Background: Assessing patient's perspective provides useful information enabling a customized approach which has been advocated by current guidelines. In this multicentre cross-sectional study we evaluated personal viewpoints on allergen-specific immunotherapy (SIT) in patients treated with subcutaneous (SCIT) or sublingual (SLIT) immunotherapy. Methods: A survey of 28 questions assessing patient'

Background: Fibrinogen concentrate treatment can improve coagulation during massive traumatic bleeding. The aim of this in vitro study was to determine whether fibrinogen concentrate, or a combination of factor XIII and fibrinogen concentrates, could reverse a haemodilution-induced coagulopathy during hypothermia. Methods: Citrated venous blood from 10 healthy volunteers was diluted in vitro by 33

The article discusses research which focused on the influence of Critical Management Studies (CMS) on the goals of firms to attain corporate sustainability (CS). The researchers argued that both CMS and CS share objectives that are overlapping in various ways and aim to contribute to the issue concerning how CS can be studied critically and address the problem related to the relevance of CMS-inspi

Possible deformation of odd-N nuclei with N approximate to 28 toward the neutron drip line is investigated using the Nilsson diagram based on deformed Woods-Saxon potentials. Both weakly-bound and resonant one-particle levels are properly obtained by directly solving the Schrodinger equation in mesh of space coordinate with the correct boundary condition. If we use the same diffuseness of the pote

»Schweden in Gefangenschaft der Barbaresken: Die politische Kultur humaner Sicherheit, circa 1660-1760«. This article aims to present a specificform of “Human Security” during the Early Modern era. As a case study, the relationship between Sweden and the North African states will be put forward. The Swedish maritime expansion in the Mediterranean during the 17th century resulted in insecurity for

Populations of Pipistrellus nathusii (Nathusius's bat), an insectivorous aerial-hawking species that breeds in north-eastern Europe, perform long-distance migrations between breeding sites and hibernation areas in central and southern Europe. The feeding strategy of migrating P nathusii was investigated in Latvia on the east coast of the Baltic Sea, exploring evidence for and against two non-mutua

We review some new literature on diatoms, with emphasis on genomics, evolution, ecology and biomimetic nanotechnical applications. Diatoms account for a substantial part of the photosynthetic production on this planet, and their genome is a mosaic of contributions from different sources. They occupy very diverse ecological niches, and may have been the first organisms to carry out C4 photosynthesi

Popular Abstract in Swedish Sammanfattning på svenska Den svenska nationella cancerstategin från 2009 understryker patientperspektivet och fokus ligger på själva patientprocessen. Modern bröstcancerbehandling omfattar en mer individualiserad behandling med bröstbevarande kirurgi, diagnostik av portvaktskörteln, ett ökat användande av medicinsk terapi med cellgift, antihormon samt antikroppar i såAbstract Background. The Swedish national cancer strategy programme published in 2009 emphasises the patient perspective and focuses on the patient process. Over the years the different modalities in breast cancer treatment are changing position, making accurate diagnosis and quality assurance in breast pathology even more important than before. Aims. The aim of paper I was to examine overall su

Four fire extinguishing agents has been investigated, bromotrifluoromethane, Halon 1301, pentafluoroethane, HFC 125, heptafluoropropane, HFC 227ea and dodecafluoro-2- methylpentane-3-one, C6F-ketone. The inerting concentrations were determined in a cubic pressure vessel with a volume of 8 litres. A cup burner was used to find the flameextinguishing concentrations for the agents. Thermal breakdown

WUSCHEL (WUS) is a homeodomain transcription factor produced in cells of the niche/organizing center (OC) of shoot apical meristems. WUS specifies stem cell fate and also restricts its own levels by activating a negative regulator, CLAVATA3 (CLV3), in adjacent cells of the central zone (CZ). Here we show that the WUS protein, after being synthesized in cells of the OC, migrates into the CZ, where