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Aims: We investigated the sequential gene expression in the gingiva during the induction and resolution of experimental gingivitis. Material and Methods: Twenty periodontally and systemically healthy non-smoking volunteers participated in a 3-week experimental gingivitis protocol, followed by debridement and 2-week regular plaque control. We recorded clinical indices and harvested gingival tissue
Spirocyclic acetal structures have recently received growing attention in polymer science due to their dual potential to raise the glass transition temperature (Tg) and enable chemical recycling of biobased polymers. In the present work, a vanillin-based diol with a spirocyclic acetal structure was incorporated in a series of rigid amorphous polyesters based on neopentyl glycol and dimethyl t
BACKGROUND: The importance of socioeconomic status for survival in cirrhosis patients is more or less pronounced within different populations, most likely due to cultural and regional differences combined with dissimilarities in healthcare system organisation and accessibility. Our aim was to study the survival of patients with cirrhosis in a population-based Swedish cohort, using available data o
Objective: We examined the incidence and natural history of macular retinochoroidal neovascularization (RCN) in enhanced S-cone syndrome (ESCS). Design: Retrospective case series. Methods: This single-center study included 14 of 93 patients with ESCS who had signs of active or inactive RCN in ≥1 eye. We conducted multimodal retinal imaging, full-field electroretinography, and molecular genetic ana
The formation of α-synuclein aggregates is a major pathological hallmark of Parkinson's disease. Copper promotes α-synuclein aggregation and toxicity in vitro. The level of copper and copper transporter 1, which is the only known high-affinity copper importer in the brain, decreases in the substantia nigra of Parkinson's disease patients. However, the relationship between copper, copper transporte
The economics of biobanking are intertwined with its social and scientific aspects. In this article, we illustrate this interrelationship and describe two problems that structure the discussion about the economics of biobanking. First, there is a “sustainability problem” about how to maintain biobanks in the long term. Second, and representing a partial response to the first problem, there is a “c
Paired records of δ13Ccarb and δ13Corg across the Llandovery-Wenlock boundary demonstrate asynchronous behavior during the onset of the Ireviken Biogeochemical Event (IBE). The extremely high-resolution data produced from the Altajme Core, drilled from Gotland, Sweden, capture a negative excursion in δ13Corg during the initiation of the Ireviken Extinction Event (IEE) and prior to the onset of the
In this paper we study the Lilang Super Group in the Spiti area, Indian Himalaya to understand environmental changes in the aftermath of the end-Permian mass extinction. We focus on the Mikin and Kaga Formations, which span the Induan to Ladinian stages of the Lower and Middle Triassic. These strata formed on the southern mid-palaeolatitude margin of East Gondwana and are interpreted as condensed,
Background: The introduction of a paper-based Community Case Management (CCM) in Malawi has contributed to a reduction of child morbidity and mortality rates. In addition, the introduction of electronic Community Case Management (eCCM) (smartphones with built in CCM apps) may help to reduce the under-five mortality rates even further. Purpose: It is not uncommon for Apps with a similar area of int
Conodont ecology of the Early Triassic Smithian–Spathian transition is still poorly understood. Here we use oxygen isotope ratios of monogeneric conodonts from Omani samples to reveal the differences of oxygen isotopic composition between different taxa. Oxygen isotope analyses from Oman reveal that Neogondolella inhabited a deeper part of the water column relative to neospathodids and Icriospatho
Alpha-1-microglobulin (A1M) is an antioxidant previously shown to be elevated in maternal blood during pregnancies complicated by preeclampsia and suggested to be important in the endogenous defense against oxidative stress. A knockout mouse model of A1M (A1Mko) was used in the present study to assess the importance of A1M during pregnancy in relation to the kidney, heart and placenta function. Sy
Background: The purpose of this study was to prospectively recruit patients treated with limb malformation and to explore the prevalence and the clinical and epidemiological features of Heart-Hand Syndrome (HHS) in China. Methods: The consecutive patients treated for congenital upper limb malformation in Beijing Ji Shui Tan Hospital from October 1st, 2016 to October 1st, 2019 were prospectively re
Abstract: Spasticity interfering with gross motor development in cerebral palsy (CP) can be reduced with selective dorsal rhizotomy (SDR). Although reported, it is unknown if SDR surgery causes later spine problems. Using CP-registry data from a geographically defined population, the objectives were to compare frequency and time to scoliosis, and spinal pain up to adult age after SDR-surgery or no
The prevalence of type 2 diabetes (T2D) has increased dramatically in Middle Eastern populations that represent the largest non-European immigrant group in Sweden today. As proneurotensin predicts T2D, the aim of this study was to investigate differences in proneurotensin levels across populations of Middle Eastern and Caucasian origin and to study its associations with indices of glucose regulati
