Formerly known as the Advanced Microscopy Platform The MultiPark Microscopy Platform currently has a Leica SP8 laser scanning confocal microscope for imaging live and fixed tissue and cells. The system is also equipped with a live imaging chamber, which can be used with additional training. The system is located in BMC A1054 and has been up and running since late 2019.Using the systemIntroductionA

https://www.multipark.lu.se/infrastructures/microscopy-platform/leica-sp8-confocal-lsm - 2025-07-19

MultiPark has acquired a Sapphire imager and a dedicated license for Sapphire imaging data analysis. Equipment features: Laser scanning systems, the Sapphire Biomolecular Imager, which delivers the following imaging modalities with higher sensitivity (protein detection in the femtogram range): Bright-field and Multiplex fluorescent detection Chemiluminescent imaging Sapphire Biomolecular Imager ha

https://www.multipark.lu.se/infrastructures/sapphire-imaging-platform - 2025-07-19

Formerly known as the Image Visualization and Analysis Software platform MultiPark currently holds a fixed license for Imaris SingleFull with Clearview version 10.2, which is located on a dedicated workstation in BMC B1155. This software is especially suited for 3D/4D visualization of image stacks that have been acquired with, for example, a confocal microscope. More information about this softwar

https://www.multipark.lu.se/infrastructures/microscopy-platform/imaris-version-102 - 2025-07-19

Description of the platformIn the last decade it has become clear that the underlying disease pathologies of Alzheimer's disease (AD) and Parkinson's disease (PD) start to accumulate several decades before onset of overt symptoms. We can now use biomarkers to reliably detect these disease pathologies (e.g., amyloid-beta, tau and alpha-synuclein) even during pre-symptomatic and prodromal phases of

https://www.multipark.lu.se/infrastructures/swetrap-swedish-trial-ready-cohorts-early-alzheimers-and-parkinsons-diseases - 2025-07-19

Special interest groups (SIGs) are groups of scientists encompassing all academic levels, from PhD students to Professors, who meet regularly to create opportunities for in-depth scientific discussion and collaborations. The SIGs are self-organizing and self-managing groups. Genetics Andreas Puschmann Fluid biomarkers Sebastian Palmqvist Cellular reprogramming Henrik Ahlenius Brain circuit analysi

https://www.multipark.lu.se/research/special-interest-groups-0 - 2025-07-19

Formerly known as the Live Cell Imaging platform Live imaging is an important tool for studying the molecular and cellular functions of neuronal and non-neuronal cells and tissue. It has a broad range of applications, such as exploring disease mechanisms, assisting with clinical diagnosis and development of new treatments. This system gives MultiPark scientists an opportunity to study single molec

https://www.multipark.lu.se/infrastructures/microscopy-platform/live-imaging-system - 2025-07-19

The Brain Circuit Analysis Special Interest Group studies neuronal circuits in health and disease using advanced methods for the perturbation and recording of cell activity.  Inducible viral vectors can be used to investigate the effect of human alpha synucelin on dopamine release and reuptake inside the rodent brain. Photo: Andreas Heuer's group. In alignment with MultiPark's strategic goals Eluc

https://www.multipark.lu.se/brain-circuit-analysis - 2025-07-19

This group brings together researchers who look for causes of neurodegenerative diseases in the genetic code of our patient series and families. DNA from an increasing number of patients is being examined by whole genome or whole exome sequencing methods, and group members are involved in the genetic analyses of this genetic data. Fictive pedigree. A pedigree can be useful for keeping track of her

https://www.multipark.lu.se/genetics-neurodegenerative-diseases - 2025-07-19

The Molecular Signaling Special Interest Group focus on genetics and their effects on different neurodegenerative disorders. Everything from gene expression, gene therapy, and epigenetic mechanisms is considered. In substantia nigra, neurons expressing Calretinin seem to be more resistant to damage. Photo: Lautaro Belfiori. This SIG combines a broad range of research topics. These include genetics

https://www.multipark.lu.se/molecular-signaling-neurodegenerative-diseases - 2025-07-19

The MESO QuickPlex SQ 120 is a multiplexing plate reader using high-performance, electrochemiluminescence (ECL) immunoassays for detecting biomarkers. The instrument allows for precise quantitation of single or multiple, low to elevated abundance analytes, in a single sample. The MULTI-ARRAY technology has increased dynamic range, improved sensitivity, reduced sample volume and reagent requirement

https://www.multipark.lu.se/infrastructures/meso-quickplex - 2025-07-19

MultiPark supports up to 50% of a clinical bioinformatician, for projects within the aims of MultiPark.The bioinformatician works with bioinformatic analyses of genetic data from high throughput genetic sequencing from patients and families with Parkinson disease, dementia, other movement disorders and cerebrovascular disorders. Tasks/expertise include the identification of disease-associated gene

https://www.multipark.lu.se/infrastructures/clinical-bioinformatics-infrastructure - 2025-07-19

MultiPark NGS database is completed and available to interested MultiPark researchers. Data from whole exome sequencing of 287 clinically well-characterized Parkinson disease patients from southern Sweden is now available in the MultiPark NGS database. Patients had been recruited within the PARkinsonLUnd (PARLU) study and MultiPark’s biobank sample collection(MPBC). Great care has been taken to en

https://www.multipark.lu.se/infrastructures/ngs-database-infrastructure - 2025-07-19

High-content analysis system High content screening (HCS) / Analysis (HCA) enables automated acquisition, visualization and quantification of a large number of images and can capture and measure dynamic processes, such as migration and/or changes in morphology, expression pattern and/or intensity.This system featuresAutomated fluorescence and brightfield microscopyWidefield and confocal (spinning

https://www.multipark.lu.se/infrastructures/operetta-cls - 2025-07-19

According to a decision made by the MultiPark board, the infrastructures have been evaluated. Kajsa Paulsson, one of the external board members, has been responsible for this process. Read the general conclusions of the evaluation report from November 2022 here:  Evaluation of the MultiPark Research Infrastructures Nov 2022.pdf

https://www.multipark.lu.se/infrastructures/infrastructure-evaluation - 2025-07-19

Read about our latest scientific discoveries See all publications from our research groups here. 

https://www.multipark.lu.se/research/publications - 2025-07-19

Visit MultiPark Café (link to Swedish event site) MultiPark Café MultiPark Café is a series of popular science lectures (in Swedish) where our researchers present their latest discoveries. The seminars are aimed at patient associations and the general public and each evening has a specific theme.More information about these events can be found on our Swedish homepage. Listen to Meet our scientists

https://www.multipark.lu.se/outreaching-activities-0 - 2025-07-19

As of January 2025, the sequencing services previously provided by the MultiPark Neuroscience Omics Facility (formerly known as the Next Generation Sequencing Facility) can be accessed by directly contacting the Center for Translational Genomics at Lund University (https://www.ctg.lu.se/ctg-center-translational-genomics).Some equipment funded by MultiPark for use in the former facility will still

https://www.multipark.lu.se/infrastructures/ngs-equipment - 2025-07-19

PET imaging of the brain is a powerful method to study physiology and disease in the living brain of humans as well as animal models. The unit for nuclear medicin at Skåne University Hospital provides radioligands for both experimental and clinical use. Besides 18F-FDG, they also synthesize a range of other PET tracers such as ligands binding to the dopamine transporter, tau filaments or β-amyloid

https://www.multipark.lu.se/infrastructures/pet-ligand-radiosynthesis-platform - 2025-07-19

High content screening (HCS)/Analysis (HCA) Left: photo of the Plate Runner HD from Trophos. Upper right: whole well image of culture well (96 well plate format) containing human induced pluripotent stem cells grown on mouse feeders, stained for pluripotent markers NANOG (red) and OCT4 (green). The cell nuclei is stained with DAPI (blue). Lower right: whole well image of culture well (96 well plat

https://www.multipark.lu.se/infrastructures/plate-runner-platform - 2025-07-19

Quanterix SR-X Ultra-Sensitive Biomarker Detection System The Simoa Analyzer is particularly useful for measurements of biomarkers at ultra-low levels.The Simoa Analyzer system features:Single molecule array technique for high sensitivity and broad dynamic rangeCombined digital and analog immunoassay dynamic range is >4 logsA range of sample types include serum, plasma, cerebrospinal fluid, urine,

https://www.multipark.lu.se/infrastructures/simoa-analyzer - 2025-07-19