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Background: Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by a CAG repeat expansion in the HD gene. The huntingtin protein expressed from HD has an unknown function but is suggested to interact with proteins involved in the cell division machinery. The R6/2 transgenic mouse is the most widely used model to study HD. In R6/2 fibroblast cultures, a reduced mitotic index
Associative learning in the cerebellum underlies motor memories and probably also cognitive associations. Pavlovian eyeblink conditioning, a widely used experimental model of such learning, depends on the cerebellum, but the memory locus within the cerebellum as well as the underlying mechanisms have remained controversial. To date, crucial information on how cerebellar Purkinje cells change their
Failure of response to treatment or recurrent disease is often noted in patients with penile intraepithelial neoplasia. Photodynamic therapy has recently been added to the list of treatment modalities used for this diagnosis. Our primary objective was to study the results of photodynamic therapy in the treatment of penile intraepithelial neoplasia in men over the age of 40 years. Ten patients aged
Four cases of atlanto-occipital dislocation are described. Two of the cases were found in a material of 407 patients with rheumatoid arthritis indicating a frequency of 0.5 per cent. All the patients had severe mutilating changes of the peripheral joints as well as of the cervical spine and all developed severe neurologic symptoms. The diagnosis is not easy to set on conventional films so conventi
Several previous authors have argued that Finnish lacks a true passive construction, and relabel the form ''indefinite,''''impersonal'' or ''suppressive'.' In this paper, we first devise a set of criteria for passives cross-linguistically; we then present syntactic and morphological evidence to show that the Finnish construction displays all the key features we would expect from a passive.
The main aim of this study was to evaluate an occupational therapy based intervention aimed at increasing the accessibility to buildings with public facilities in a Swedish town centre, which targeted physical environmental barriers. The intervention was occupational therapy advice based on the environmental assessments of each facility, given to the facility owners in order to ease the removal of
OBJECTIVES: To assess the coexistence of hypertension and diabetes, associations with cardiovascular risk factors and the achievement of current treatment goals. DESIGN: A community-based, cross-sectional, observational study. SETTING: Hypertension and diabetes outpatient clinics in primary health care, Skara, Sweden. SUBJECTS: All patients (n = 1116; 488 men, 628 women) who performed an annual fo
We discuss the design elements of a compact free electron laser device, operating, in an oscillator-amplifier configuration, up to the soft X-ray region. We show that, the source can provide radiation from extreme UV to soft X-ray region, with significantly large output peak and average laser power with undulator lengths not exceeding 7 in.
The authors assessed determinants of ergosterol, 3-OH fatty acids (FAs), and viable microbes in vacuum cleaner dust, and investioated the association between these microbial markets and childhood asthma. The authors studied the homes of 36 children who were new cases of childhood asthma and the homes of 36 controls. Home characteristics explained 34% to 44% of the variation in levels of different
Periodontitis is an inflammatory disease of the supporting structures of the teeth and is caused by, among other agents, Porphyromonas gingivalis. P. gingivalis is very resistant to killing by human complement, which is present in a gingival fluid at 70% of the serum concentration. We found that the incubation of human serum with purified cysteine proteases of P. gingivalis (gingipains) or P. ging
All accounts of communicative behaviour in general, and communicative strategies in particular, mention gesture1 in relation to language acquisition (cf. Faerch & Kasper 1983 for an overview). However, few attempts have been made to investigate how spoken language and spontaneous gesture combine to determine discourse referents. Referential gesture and referential discourse will be of particul
In balance clinic practice, phobic postural vertigo is a term used to define a population with dizziness and avoidance behavior often as a consequence of a vestibular disorder. It has been described as the most common form of dizziness in middle aged patients in dizziness units. Anxiety disorders are common among patients with vestibular disorders. Cognitive-behavioral therapy is an effective trea
Each right-invariant metric on the Virasoro group induces a Hamiltonian vector field on the dual of the Lie algebra Dir equipped with the canonical Lie-Poisson structure. We show that the Hamiltonian vector fields X-k induced by the metrics given at the identity by the H-k Sobolev inner products, k >= 0, are bi-Hamiltonian relative to a modified Lie-Poisson structure only for k = 0 and k = 1. (c)
The aim of this study was to determine the threshold of fracture probability at which interventions became cost-effective in men and women, based on data from Sweden. We modeled the effects of a treatment costing $500 per year given for 5 years that decreased the risk of all osteoporotic fractures by 35% followed by a waning of effect for a further 5 years. Sensitivity analyses included a range of
We examine bosonic atoms that are confined in a toroidal, quasi-one-dimensional trap, subjected to a random potential. The resulting inhomogeneous atomic density is smoothened for sufficiently strong, repulsive interatomic interactions. Statistical analysis of our simulations show that the gas supports persistent currents, which become more fragile due to the disorder.
