Acetaminophen is one of the most common over-the-counter pain medications used worldwide and is considered safe at therapeutic dose. However, intentional and unintentional overdose accounts for up to 70% of acute liver failure cases in the western world. Extensive research has demonstrated that the induction of oxidative stress and mitochondrial dysfunction are central to the development of acetam

Background: Circulating levels of TNF alpha receptor 1 (TNFR1) and 2 (TNFR2) are associated with increased long-term mortality and impaired kidney function. Aim: To study association between circulating levels of TNFR1 and TNFR2 and short-term mortality in patients with diabetes and dyspnea. Population and methods: Patients aged ≥ 18 years seeking at emergency department (ED) during daytime on wee

Vertical nanowires with cointegrated metal-oxide-semiconductor field-effect-transistor (MOSFET) selectors and nonvolatile resistive random access memory (RRAM) cells represent a promising candidate for fast, energy-efficient, cross-point memory cells. This paper explores indium-tin-oxide-hafnium-dioxide RRAM cells integrated onto arrays of indium-arsenide (InAs) vertical nanowires with a resulting

Purpose: In early 2000s Six Sigma and Lean were combined into Lean Six Sigma (LSS), which has been one of the major strategic quality initiatives all over the world. Now, we are in the era of the 4th Industrial Revolution (IR), which changes almost everything including LSS and quality management (QM) in the companies. We need new paradigm of LSS to boost LSS activities in this 4th IR era. In this

Clinical researchers use disease progression models to understand patient status and characterize progression patterns from longitudinal health records. One approach for disease progression modeling is to describe patient status using a small number of states that represent distinctive distributions over a set of observed measures. Hidden Markov models (HMMs) and its variants are a class of models

The pathophysiology of Parkinson's disease, dementia with Lewy bodies, multiple system atrophy, and many others converge at alpha-synuclein (α-Syn) aggregation. Although it is still not entirely clear what precise biophysical processes act as triggers, cumulative evidence points towards a crucial role for protein quality control (PQC) systems in modulating α-Syn aggregation and toxicity. These enc

Venoarterial (VA) extracorporeal membrane oxygenation (ECMO) support for postcardiotomy cardiogenic shock (PCS) in patients undergoing surgery for acute type A aortic dissection (TAAD) is controversial and the available evidence is confined to limited case series. We aimed to evaluate the impact of this salvage therapy in this patient population. Between January 2010 and March 2018, all TAAD patie

Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.Samarbetet mellan forskare i Östersjöregionen har aldrig varit starkare. Ändå finns stora utmaningar, vilket blir tydligt i en aktuell debatt i Tyskland om digitaliseringar i vården där politiker lyfter fram Sverige som förebild.

Purpose: In addition to incisional hernia, inguinal hernia is a recognized complication to radical retropubic prostatectomy. To compare the risk of developing inguinal and incisional hernias after open radical prostatectomy compared to robot-assisted laparoscopic prostatectomy. Method: Patients planned for prostatectomy were enrolled in the prospective, controlled LAPPRO trial between September 20

We present and analyze a new approach to improve energy efficiency in cellular IoT devices. The new approach consists of employment of ultra low power wake-up receivers in combination with robust non-coherent modulation. The results show that we can achieve very competitive power consumption, reducing it by up to 50 times, compared to two conventional power saving solutions we use as references. T

A key challenge in X-ray crystallography is to find a good point on the crystal on which to center the beam because the crystal takes radiation damage after a number of shots which significantly distort the measurements. Therefore, the beam needs to be aimed manually by an operator, which results in significant additional effort and time.This paper presents an approach toward automating the beam a

We envision the use of large intelligent surface (LIS) technology, which is a promising concept that goes beyond massive multiple-input multiple-output (MIMO), for positioning applications due to its ability to focus energy in the 3D space. The Cramér-Rao lower bounds (CBLBs) for positioning using a LIS which can resolve amplitude and phase with full resolution have already been determined in the

The case is about grassroots monetary innovations carried out for social purposes. Through the case of the Kenyan community currencies the reader gets an insight into the social challenges these currencies aim to address, the effort that goes into designing these local monies as well as into organising the communities that use them. The reader is presented with the practical challenges faced by th

Hanseatic League of Science (HALOS)Hanseatic League of Science (HALOS) is a unique cross-border ÖKS interreg project with 15 official partner organizations including research institutes in Denmark, Sweden and Germany. Through HALOS the Life Science research and innovation ecosystems will get access to crossborder cooperation platforms where academia and industry can meet. Key stakeholders will be

Connecting the complementary facilities MAX IV & ESS with DESY & European X-FEL creates synergy and a globally unique infrastructure region with fantastic opportunities for innovation and research not least in Life Science. Through Hanseatic League of Science (HALOS) the Life Science research and innovation ecosystems is given a joint platform to take advantage of the facilities and a tool

The increase of plasma levels of high-density lipoproteins and Apolipoprotein A-I (ApoA-I), its main protein component, has been shown to have a positive action on glucose disposal in type 2 diabetic patients. The current study investigates the unexplored function of ApoA-I to prime beta cells for improved insulin secretion. INS-1E rat clonal beta cells as well as isolated murine islets were used