BACKGROUND: Single nucleotide polymorphisms (SNPs) in the promoter region of CRYAB gene have been associated with in multiple sclerosis. CRYAB gene, which encodes alpha B-crystallin (a member of small heat shock protein), was reported as a potential autoimmune target. In this study we investigated whether SNPs in the promoter region of CRYAB gene were also important in the etiology of Type 1 diabe

BACKGROUND: Sodium-glucose co-transporter (SGLT) inhibitors reduce cardiovascular outcomes including mortality in several populations; however, their effect on atrial fibrillation/flutter (AF) remains unclear. Our objective was to determine whether SGLT inhibitors reduce AF and whether a history of AF modifies the effect of SGLT inhibitors on the composite of heart failure hospitalization or cardi

Anisotropic particles are known to exhibit a richer and more complex phase behavior in comparison to their spherical counterpart. While the majority of the existing studies address structural properties, the dynamic behavior of anisotropic particles is a relatively lesser explored avenue. Using multispeckle ultra-small-angle x-ray photon correlation spectroscopy (USA-XPCS), we have carried out a s

Pooling metabolomics data across studies is often desirable to increase the statistical power of the analysis. However, this can raise methodological challenges as several preanalytical and analytical factors could introduce differences in measured concentrations and variability between datasets. Specifically, different studies may use variable sample types (e.g., serum versus plasma) collected, t

We present an extension of the atomic frequency comb protocol that utilizes the Stark effect to perform noise-free, on-demand, control. An experimental realization of this protocol was implemented in the Pr3+:Y2SiO5 solid-state system, and a recall efficiency of 38% for a 0.8 μs storage time was achieved. Experiments were performed with both bright pulses as well as weak-coherent states, the latte

G protein-coupled receptor 30 (GPR30) is a membrane receptor reported to bind 17b-estradiol (E2) and mediate rapid nongenomic estrogen responses, hence also named G protein-coupled estrogen receptor. G-1 is a proposed GPR30-specific agonist that has been used to implicate the receptor in several pathophysiological events. However, controversy surrounds the role of GPR30 in G-1 and E2 responses. We

To enable authentic interfacing with neuronal structures in the brain, preventing alterations of tissue during implantation of devices is critical. By transiently implanting oxygen microsensors into rat cortex cerebri for 2 h, substantial and long lasting (>1 h) hypoxia is routinely generated in surrounding tissues; this hypoxia is linked to implantation generated compressive forces. Preferential

Guidelines aim to standardise and optimise asthma diagnosis and management. Nevertheless, adherence to guidelines is suboptimal and may vary across different healthcare professional (HCP) groups. Further to these concerns, this European Respiratory Society (ERS)/European Academy of Allergy and Clinical Immunology (EAACI) statement aims to: 1) evaluate the understanding of and adherence to internat

Despite the many benefits of pulses, their consumption is still very low in many Western countries. One approach to solving this issue is to develop attractive pulse‐based foods, e.g., plant-based cheeses. This study aimed to assess the suitability of different types of pulse flour, from boiled and roasted yellow peas and faba beans, to develop plant‐based cheese analogues. Different stabilizer co

In this article, the Swedish findings from a European comparative study on 0-3-year-old children and their digital lives are presented and discussed in relation to domestication theory, including the concept of moral economy. More specifically, attention is paid to toddler's appropriation of digital technology and the parents' moral struggles: the negotiations between the parents concerning the in

CsPbBr3 quantum dots (QDs) are promising candidates for optoelectronic devices. The substitution of oleic acid (OA) and oleylamine (OLA) capping agents with a quaternary alkylammonium such as di-dodecyl dimethyl ammonium bromide (DDAB) has shown an increase in external quantum efficiency (EQE) from 0.19% (OA/OLA) to 13.4% (DDAB) in LED devices. The device performance significantly depends on both

Autologous (auto-) and allogeneic (allo-) hematopoietic cell transplantation (HCT) are accepted treatment modalities in contemporary treatment algorithms for mantle cell lymphoma (MCL). Chimeric antigen receptor (CAR) T cell therapy recently received approval for MCL; however, its exact place and sequence in relation to HCT remain unclear. The American Society of Transplantation and Cellular Thera

Security for outsourced control applications can be provided if the physical plant is enabled with a mechanism to verify the control signal received from the cloud. Recent developments in modern cryptography claim the applicability of verifiable computation techniques. Such techniques allow a client to check the correctness of a remote execution. This article delivers a proof of concept for applic

The etiology of type 1 diabetes (T1D) remains unknown, but a growing body of evidence points to infectious agents and/or components of early childhood diet. The National Institutes of Health has established the TEDDY Study consortium of six clinical centers in the United States and Europe and a data coordinating center to identify environmental factors predisposing to, or protective against, islet

Connecting actors across sectors, scales and decision-making arenas, complex global networks make up central elements of the social structure of earth system governance. Taking a relational perspective, the notion of global socio-technical regimes places networks within the centre of discussions on stability and change. Described as dominant institutional rationalities diffusing through internatio

PurposeThe authors discuss a dominant logic as the main idea behind a global marketing logic (GML) of an MNE and investigate how local stakeholders’ influence the feasibility of applying the GML in emerging markets. The aim of the paper is to enhance the understanding of the factors that influence the local stakeholders' acceptance of the MNEs' GML and the different activities of MNEs that may inc

Internationalised networks constitute a central aspect of global socio-technical systems and the governing and organisation of global markets. Yet, their role in sustainability transitions has not received much attention in the transition studies literature. To inform and expand recent theorisation on the global nature of socio-technical regimes, this paper engages with role of global networks in