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Objective: Low-carbohydrate, high-fat diets under eucaloric conditions are associated with several health-beneficial metabolic effects in humans, particularly in the liver. We recently observed that apolipoprotein A-IV (apoA-IV), a highly abundant apolipoprotein, was among the most upregulated proteins in circulation after six weeks of consuming a high-fat diet in humans. However, the impact of di

We report on the epitaxial growth of Bi2WO6 thin films by Pulsed Laser Deposition using a high-power infrared Nd:YAG laser source. X-ray diffraction investigation confirms that single (00l)-oriented thin films can be obtained on both LSAT and SrTiO3 substrates by using a LaNiO3 adapting layer. Moreover, reciprocal space maps show that the films coherently grow on such substrates with the in-plane

Hydrogels for biomedical applications have been widely studied once they are able to enhance the wound-healing process, as well as facilitate the controlled release and loading of drugs. In this context, Pluronic F127 (PF127) has a major role as it was shown to have exceptional versatility, once it holds unique gelation properties, as it is thermoreversible and is liquid in lower temperatures, and

Dystonia is a movement disorder characterized by genetic and clinical heterogeneity. A recurring p.(Glu303del)-deletion in TOR1A is a well-established cause for DYT-TOR1A (DYT1), an autosomal dominant early-onset isolated dystonia. TOR1A encodes TorsinA, an AAA + ATPase located in the nuclear envelope. By whole exome analyses of a family with a novel dystonia-hemichorea-/hemiballism phenotype, we

This paper presents an in-depth analysis of the stability and performance of control systems experiencing sensor timing misalignments, a common challenge in practical applications such as autonomous vehicles and aerospace systems. We model multichannel sensor delays as independent random variables, capturing the variability of real-world systems where different sensors exhibit distinct and non-con

Life on Earth is a mosaic distributed across biogeographical regions. Their regional species pools have experienced distinct historical and eco-evolutionary pressures, leading to an expected context-dependent organization of biodiversity. Here we identify a general spatial organization within biogeographical regions of terrestrial and marine vertebrates, invertebrates and plants (more than 30,000

The transition to farming in the coastal environments of southern Scandinavia remains a key conundrum in European prehistory. This region was heavily exploited by Late Mesolithic communities of the Ertebølle culture, complex hunter-fisher-gatherers who flourished for some 1500 years prior to the arrival of farming at around 4000 BCE marking the start of the Neolithic period. Extensive genetic and The transition to farming in the coastal environments of southern Scandinavia remains a key conundrum in European prehistory. This region was heavily exploited by Late Mesolithic communities of the Ertebølle culture, complex hunter-fisher-gatherers who flourished for some 1500 years prior to the arrival of farming at around 4000 BCE marking the start of the Neolithic period. Extensive genetic and

Fish played a vital role in the development of the European Mesolithic; from their colonization of the continent during the Upper Palaeolithic to ongoing debates regarding their importance across the Neolithic transition, they are central to many discussions. Here, we focus on the European Mesolithic zooarchaeological fish dataset, in which we have collated >640,000 identified fish remains from 35

This article assesses what is analytically at stake when individuals claim that their rights under the European Convention on Human Rights have been interfered with and the respondent State invokes compliance with positive human rights obligations as the aim pursued with the interference. These situations could be framed as manifesting a tension between negative and positive obligations. This is a

ObjectiveTo identify factors associated with velopharyngeal competence at 10 years of age in children with cleft palate, and examine the longitudinal development of velopharyngeal competence.DesignRegistry-based cohort study.SettingRegional public care university hospitals in Sweden.ParticipantsA total of 507 children born with a cleft palate with or without cleft lip/alveolus.Main Outcome Measure

ObjectivesPatient perceived benefit of treatment for cleft lip and/or palate is of great importance since it is central to development of cleft care. CLEFT-Q is a cleft-specific questionnaire on health-related quality of life. Test-retest reliability, aspects of responsiveness and interpretability are yet to be established for CLEFT-Q. This study aims to investigate these psychometric characterist

This study investigated the birth prevalence of cleft lip and/or palate (CL/P) in Sweden between 2000 and 2020 using data from the Swedish National Medical Birth Register, which includes over 97% of children born in the country, and its subregister the National Register of Congenital Anomalies. The dataset included 2,230,771 anonymized children, with the variables year of birth, sex and diagnoses

Astrocytes are essential for maintaining neuronal health and regulating the brain's inflammatory environment. In this study, we developed an adeno-associated viral vector (AAV9) designed to selectively overexpress glial cell line-derived neurotrophic factor (GDNF) in astrocytes, using the astrocyte-specific GFAP promoter and TdTomato for transduction tracking. This approach yielded targeted GDNF e

Bakgrund: Det är ett välkänt faktum att den demografiska utvecklingen kommer att kräva nya arbetssätt för att äldre ska kunna få vård i liknande omfattning som tidigare. Förhoppningen har ställts till införandet av välfärdsteknik som en viktig del av kompetensförsörjningen, inte bara för att den kan bidra till att upprätthålla välfärden trots fler äldre, utan också genom att göra äldreomsorgsarbet