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Validation of fluid-structure interaction simulations of the opening phase of phantom mitral heart valves under physiologically inspired conditions

Background and objectiveAtrioventricular valve disease is a common cause of heart failure, and successful surgical or interventional outcomes are crucial. Patient-specific fluid-structure interaction (FSI) modeling may provide valuable insights into valve dynamics and guidance of valve repair strategies. However, lack of validation has kept FSI modeling from clinical implementation. Therefore, thi

A genome-wide association study of social trust in 33,882 Danish blood donors

Social trust is a heritable trait that has been linked with physical health and longevity. In this study, we performed genome-wide association studies of self-reported social trust in n = 33,882 Danish blood donors. We observed genome-wide and local evidence of genetic similarity with other brain-related phenotypes and estimated the single nucleotide polymorphism-based heritability of trust to be

Dramaturgies of Conversation to address challenges to Democracy

Dramaturgies of Conversation to address challenges to Democracy Democracy is now the system to govern in just a little more than thirty countries, but dictatorships harbour seventy percent of the world population. Today, there is an ongoing war in Europe and in national elections in Sweden and Italy far-right parties have had successes. However, already before this happened there was great concern

Correlation Attacks on Stream Ciphers

Correlation attacks apply mainly to stream ciphers and can be considered as an extension of the idea of distinguishing attacks to collect information on secret key bits. The original correlation attack was proposed by Siegenthaler on nonlinear combination generators. In a nonlinear combination generator, the keystream is generated as the output of a Boolean function with inputs being sequences fro

A meta-analysis of previous falls and subsequent fracture risk in cohort studies

Summary: The relationship between self-reported falls and fracture risk was estimated in an international meta-analysis of individual-level data from 46 prospective cohorts. Previous falls were associated with an increased fracture risk in women and men and should be considered as an additional risk factor in the FRAX® algorithm. Introduction: Previous falls are a well-documented risk factor for s

Demographic, clinical, biomarker, and neuropathological correlates of posterior cortical atrophy: an international cohort study and individual participant data meta-analysis

Background: Posterior cortical atrophy is a rare syndrome characterised by early, prominent, and progressive impairment in visuoperceptual and visuospatial processing. The disorder has been associated with underlying neuropathological features of Alzheimer's disease, but large-scale biomarker and neuropathological studies are scarce. We aimed to describe demographic, clinical, biomarker, and neuro

Measurement of the H→ γγ and H→ ZZ∗→ 4 ℓ cross-sections in pp collisions at √s=13.6 TeV with the ATLAS detector

The inclusive Higgs boson production cross-section is measured in the di-photon and the ZZ∗→ 4 ℓ decay channels using 31.4 and 29.0 fb - 1 of pp collision data respectively, collected with the ATLAS detector at a centre-of-mass energy of s=13.6 TeV . To reduce the model dependence, the measurement in each channel is restricted to a particle-level phase space that closely matches the channel’s dete

Towards a Global Plastics Treaty: Tracing the UN Negotiations

In 2022, the United Nations Environmental Assembly (UNEA) adopted resolution 5/14, giving mandate to UN Member States to start negotiations toward an international legally binding instrument on plastic pollution. This report delves into the pre-session submissions by states and coalitions for the second (INC-2) and third (INC-3) rounds of negotiations, held in 2023. Once the contents of the docume

Historical perspectives on forestry science and monocultures : Ideas of rationality in Sweden during the early twentieth century

This study aims to broaden our historical knowledge about ideas of rationalism and monocultures in forestry science and rational forest management. Empirically, it focuses on the writings of Swedish forestry scientist Henrik Hesselman, active in the early twentieth century. The texts were analyzed using the method of historical contextualization. The study indicates that monocultures historically

Elbussar ur ett stadsplaneringsperspektiv

När man talar om elbussar framhålls ofta deras påverkan på stadsmiljöer, exempelvis vad gäller urbana kvaliteter som luftkvalitet och buller, eller hur etableringen av laddinfrastruktur ska anpassas till både den urbana kontexten och till kollektivtrafikens förutsättningar. Sedan de första elbussarna introducerades i svenska städer för ca 10 år sedan har det funnits förväntningar på att elektrifie

Electrocardiographic proarrhythmic changes in pregnancy of women with CHD

Objectives:Pregnancy-related physiological adaptations result in increased heart rate as well as electrocardiographic changes such as a mean QTc prolongation of 27 ms. Pregnant women with CHD are at increased risk for cardiovascular complications. The aim of this study was to identify risk factors for abnormally prolonged QTc interval—a risk factor for ventricular arrhythmias—in pregnant women wit

Impact of Surgery for Primary Hyperparathyroidism

Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska

Assessment of irrigation and groundwater management strategies in cold arid areas with shallow groundwater tables using a coupled year-round agro-hydrological model

Quantitatively assessing the impact of irrigation and groundwater management strategies is crucial for improving water productivity and soil salinity control in cold arid areas with shallow groundwater tables (CAASGT). However, existing studies often focus on specific periods, either the crop growth period or the freeze–thaw period, due to the lack of appropriate models that can accurately represe