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Blockchain and Federated Learning in Edge-Fog-Cloud Computing Environments for Smart Logistics

The rapid growth of smart logistics, driven by IoT devices and data-intensive applications, necessitates secure, scalable, and efficient computing frameworks. As the edge-fog-cloud (EFC) paradigm supports real-time data processing, it faces significant security threats and attacks, including privacy risks, data breaches, and unauthorized access. To address these security threats and attacks, block

Some new mitosporic lichenicolous fungi for Sweden, Norway and Fennoscandia

We report 23 lichenicolous fungi new to Sweden, among these, one is new to Europe, 21 are new to Fennoscandia, and two are newly reported for Norway. This article focuses only on mitosporic fungi. The newly reported species are Acremonium pertusariae, Cladophialophora dimorphospora, Cladosporium licheniphilum, Corynespora laevistipitata, Didymocyrtis cladoniicola, D. grumantiana, Ellisembia lichen

Threshold Effects, Cognitive Decline, and Longitudinal Changes in White Matter Hyperintensity Volume

BACKGROUND: Changes in Ischemic White matter hyperintensities volume (WMH) on MRI over time are associated with cognitive decline. We investigated whether changes in WMH volume over time exhibit WMH-normalized volume threshold effects on declining cognitive performance and whether these effects on cognition differ between deep white matter hyperintensities (DWMH) and periventricular white matter h

Managing Sustainability Alliances : A Goal-Directed Framework

To address climate change, firms are increasingly forming sustainability alliances. Pursuing sustainability via such alliances is challenging as it means working with multifaceted and not necessarily compatible goals. Moreover, it often requires collaboration among heterogeneous partners outside traditional industrial contexts as well as dealing with wicked problems. This article presents a multip

Predictors of Secukinumab Treatment Response and Continuation in Axial Spondyloarthritis : Results From the EuroSpA Research Collaboration Network

Objective. In patients with axial spondyloarthritis (axSpA) initiating secukinumab (SEC), we aimed to identify baseline (treatment start) predictors of achieving low disease activity (LDA) after 6 months, as measured by the Axial Spondyloarthritis Disease Activity Score using C-reactive protein (ASDAS-CRP) and Bath Ankylosing Spondylitis Disease Activity Index (BASDAI), as well as treatment contin

Early thinking palliative care for people with Parkinson's disease : A thematic synthesis based on a systematic mixed-methods review

Background: Parkinson's disease is a progressive neurodegenerative disorder. Awareness and the evidence supporting the merits of palliative care (PC) approaches to people with Parkinson's disease (PwP) are increasing. Objective: This review aimed to address four key questions related to PC for PwPs and their caregivers: i) What are the indicators for timely access to PC? ii) When should PC be intr

Structural insights into AQP3 channel closure upon pH and redox changes reveal an autoregulatory molecular mechanism

Regulation of intracellular levels of reactive oxygen species (ROS) remains poorly understood. Aquaporin 3 (AQP3) facilitates the membrane transport of hydrogen peroxide (H2O2), a key ROS signaling molecule. Here we elucidate the molecular mechanism of AQP3 and show that its regulatory properties are both pH dependent and autoregulated by H2O2. Using single particle cryo-electron microscopy, we pr

Repurposing statins and phenothiazines to treat chemoresistant neuroblastoma

Relapse and treatment resistance are common in children with high-risk neuroblastoma, and novel therapies are needed. Conventional drug discovery is slow, expensive, often fails in practice, and consequently falls short in addressing pediatric and rare conditions. In such instances, drug repurposing is a promising strategy. Here, we used two independent in silico prediction tools including machine

The Ideological Discourse of Putin's Russia : Sovereigntism, Neo-Imperialism, and Fascism

This essay demonstrates that the origin of modern Russian national conservatism lies in the Soviet underground anti-communist and anti-liberal movement, which developed under the strong influence of the theorists of integral traditionalism, fascism, and the Nouvelle Droite. Vladimir Putin's political ontology, based on the idea of the tragedy of Russia and Europe caused by the weakening of their s

Clinical recognition of frontotemporal dementia with right temporal predominance : a consensus statement from the International Working Group

Accurate diagnosis of frontotemporal dementia (FTD) with right anterior temporal lobe (RATL) predominance remains challenging due to lack of clinical characterization, and standardized terminology. The recent research of the International Working Group (IWG) identified common symptoms but also unveiled broad terminologies lacking precision and operationalization, with risk of misdiagnoses, inappro

Producing deceit : the influence of veracity on linguistic processes in speaking and writing

This experimental study explored how adopting a deceptive stance affects linguistic processes during real-time production of multi-sentence texts in speaking and writing. Language production involves planning, monitoring and editing – processes that give rise to and are shaped by fluctuations in processing demands. Deception is assumed to influence these processes as speakers and writers manage co

Re-interpreting rationalities of risky migration : Syrian refugees´ sea journeys to Europe Dance between wisdom and despair

The thesis explores the migration experiences of Syrian refugees who arrived in Sweden and Denmark by crossing the Mediterranean Sea in small, precarious boats. It aims to illuminate how these refugees managed the risks they faced during their journey to Europe and the meanings they associated with these risks. The research focuses on the socio-cultural and individual contexts within which risk is

Commensal Peptoniphilus harei induce activation of monocytes via TLR2/CD14 signalling in whole blood

Myeloid cells, such as monocytes, are central in the immune response to infections. However, limited knowledge exists regarding the inflammatory response to Gram-positive anaerobic cocci (GPAC). To explore the ability of GPACs to induce monocyte activation, we compared two GPAC species, Parvimonas micra and Peptoniphilus harei, with E. coli, a major cause of bloodstream infections. We stimulated w