Background: Imatinib causes increased turnover of stromal collagen, reduces collagen fibril diameter, enhances extracellular fluid turnover and lowers interstitial fluid pressure (IFP) in the human colonic carcinoma KAT-4/HT-29 (KAT-4) xenograft model. Methods: We compared the effects of imatinib on oxygen levels, vascular morphology and IFP in three experimental tumor models differing in their co

This paper describes the several phases which led, from the conceptual design, prototyping, construction and tests with beam, to the installation and operation of the BRAN (Beam RAte of Neutrals) relative luminosity monitors for the LHC. The detectors have been operating since 2009 to contribute, optimize and maintain the accelerator performance in the two high luminosity interaction regions (IR),

Mycobacterium tuberculosis (Mtb) is principally a pulmonary pathogen infecting one-third of the world's population and causing two million deaths annually. The only approved tuberculosis vaccine today is the Mycobacterium bovis bacilli Calmette-Guérin (BCG). BCG vaccine is used as a benchmark to compare the immunogenicity of new vaccines, but not much is known about its mechanisms to induce protec

Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is an indolent CD20+ lymphoma. Its scarcity has made clinical trials difficult and there is no consensus on first-line treatment. We conducted a population-based study of all patients diagnosed with NLPHL in Sweden between 2000 and 2014 (N = 158; 41 women and 117 men), focusing on clinical features, therapy and overall survival. The median fe

La2MgNi9-related alloys are superior metal hydride battery anodes as compared to the commercial AB5 alloys. Nd-substituted La2-yNdyMgNi9 intermetallics are of particular interest because of increased diffusion rate of hydrogen and thus improved performance at high discharge currents. The present work presents in operando characterization of the LaNdMgNi9 intermetallic as anode for the nickel metal

En analys av hur mångkulturalismen används av islamister i den politiska mobiliseringen för islam.

This summary proposes a critical legal analysis of the jurisprudence of the Inter-AmericanCourt of Human Rights regarding indigenous peoples’ rights to lands, participation, andconsultation. It focuses on the role that cultural diversity as a legal standard has playedin the recognition of the indigenous peoples’ right to consultation and participation inall matters that directly affect them, as a

In this work, we studied cobalt nitride (Co-N) thin films deposited using a dc magnetron sputtering method at a substrate temperature (Ts) of 523 K. We find that independent of the reactive gas flow (RN2 ) used during sputtering, the phases of Co-N formed at this temperature seems to be identical having N at.% ∼ 5. This is contrary to Co-N phases formed at lower Ts. For example at Ts∼ 300 K, an ev

UNLABELLED: Vitamin D acts through the immature osteoblast to stimulate osteoclastogenesis. Transgenic elevation of VDR in mature osteoblasts was found to inhibit osteoclastogenesis associated with an altered OPG response. This inhibition was confined to cancellous bone. This study indicates that vitamin D-mediated osteoclastogenesis is regulated locally by OPG production in the mature osteoblast.

Osteoblast-osteoclast coordination is critical in the maintenance of skeletal integrity. The modulation of osteoclastogenesis by immature cells of the osteoblastic lineage is mediated through receptor activator of NF kappa B (RANK), its ligand RANKL, and osteoprotegerin (OPG), a natural decoy receptor for RANKL. Here, the expression of OPG and RANKL in primary mouse osteoblastic cultures was inves