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Personal data and data protection

In connection to the Nordic Huntington Disease Research Meeting taking place in Lund, Sweden, on November 26 2019, we collect and process personal data in order to fulfill our task as the organizing body. The information we collect and process is the following: Name, title, affiliation, e-mail address and food preference, if necessary. The food preference is merely to ensure serving safe meals for

https://www.huntington-research.lu.se/personal-data-and-data-protection - 2025-07-27

Metabolic and behavioral effects of mutant huntingtin deletion in Sim1 neurons in the BACHD mouse model of Huntington's disease

Soylu-Kucharz R, Baldo B and Petersén Å.Scientific Reports Jun 23;6:28322 (2016)AbstractHypothalamic pathology, metabolic dysfunction and psychiatric symptoms are part of Huntington disease (HD), which is caused by an expanded CAG repeat in the huntingtin (HTT) gene. Inactivation of mutant HTT selectively in the hypothalamus prevents the development of metabolic dysfunction and depressive-like beh

https://www.huntington-research.lu.se/metabolic-and-behavioral-effects-mutant-huntingtin-deletion-sim1-neurons-bachd-mouse-model - 2025-07-27

Awards and Grants - Rachel Cheong

Grants and Scholarships 2020: Neuroförbundet, Research grant 2020: Kungliga Fysiografiska Sällskapet i Lund, Research grant 2018: Anna Lisa Rosenberg Foundation, Research grant2018: Kungliga Fysiografiska Sällskapet i Lund, Research grant 2018: Hjärnfonden, Research grant 2017: Fredrik O Ingrid Thurings Foundation, Research grant2017: Neuroförbundet, Research grant 2017: Åhlén Foundation, Research

https://www.huntington-research.lu.se/awards-and-grants-rachel-cheong - 2025-07-27

Scientific presentations - Rachel Cheong

Oral presentations Cheong RY, Hult Lundh S, Kirik D, Petersén Å. The psychiatric and metabolic phenotype of the BACHD mouse model of Huntington disease. 8th Plenary Meeting of EHDN, 2014, Spain. (Data blitz)Cheong RY, Ábrahám IM, Herbison AE. The estrogen receptor beta conundrum: A role in GnRH neurons? New Zealand Medical Science Congress, Aug 2011, Queenstown, New Zealand.Cheong RY, Kwakowsky A,

https://www.huntington-research.lu.se/scientific-presentations-rachel-cheong - 2025-07-27

Neuropeptide Y (NPY) in cerebrospinal fluid from patients with Huntington's Disease: increased NPY levels and differential degradation of the NPY1-30 fragment

Wagner L1,2,3, Björkqvist M4,5, Hult Lundh S5, Wolf R6,2, Börgel A2,7, Schlenzig D2, Ludwig HH5, Rahfeld JU2, Leavitt B7, Demuth HU2, Petersén Å4 and von Hörsten S8.Journal of Neurochemistry 137(5): 820-37 (2016)1Deutschsprachige Selbsthilfegruppe für Alkaptonurie (DSAKU) e.V, Stuttgart, Germany.2probiodrug AG, Halle (Saale, Germany.3Department of Experimental Therapy, Franz-Penzoldt-Center, Fried

https://www.huntington-research.lu.se/neuropeptide-y-npy-cerebrospinal-fluid-patients-huntingtons-disease-increased-npy-levels-and - 2025-07-27

The Role of Hypothalamic Pathology for Non-Motor Features of Huntington's Disease

Cheong RY, Gabery S and Petersén Å.Journal of Huntington's disease 8 (4): 375-391 (2019)AbstractHuntington's disease (HD) is a fatal genetic neurodegenerative disorder. It has mainly been considered a movement disorder with cognitive symptoms and these features have been associated with pathology of the striatum and cerebral cortex. Importantly, individuals with the mutant huntingtin gene suffer f

https://www.huntington-research.lu.se/role-hypothalamic-pathology-non-motor-features-huntingtons-disease - 2025-07-27

The psychopharmacology of Huntington disease

Petersén Å and Weydt P. Handbook of Clinical Neurology 15: 179-189 (2019) Abstract Huntington disease (HD) is a hereditary neurodegenerative disorder caused by an expanded cytosine-adenine-guanine triplet repeat in the huntingtin gene. The current diagnosis is based on the presence of typical motor signs in combination with a positive gene test. The motor onset of the disease is usually between 30

https://www.huntington-research.lu.se/psychopharmacology-huntington-disease - 2025-07-27

Recent advances in Huntington's disease

Niemelä V, Petersén Å, Loutfi G, Svenningsson P and Paucar M. Läkartidningen. 2020;117:FU7H Abstract Huntington's disease is an autosomal dominant neurodegenerative disease that leads to premature death. The disease is caused by a pathological CAG triplet expansion in the huntingtin gene. The disease is most common in Western populations, with onset in middle age and causing progressive motor, cog

https://www.huntington-research.lu.se/recent-advances-huntingtons-disease - 2025-07-27

Subjective sleep problems in Huntington's disease: A pilot investigation of the relationship to brain structure, neurocognitive, and neuropsychiatric function

Rochel B, Domínguez D J F, Stout J, Gabery S, Churchyard A, Chua P, Egan G, Petersén A, Georgiou-Karistianis N and Poudel G R.Journal of the Neurological Sciences 364: 148-153 (2016)AbstractSubjective reports of sleep disturbance are a common feature of Huntington's disease (HD); however, there is limited research investigating the relationship between sleep with changes in brain and behaviour. Th

https://www.huntington-research.lu.se/subjective-sleep-problems-huntingtons-disease-pilot-investigation-relationship-brain-structure - 2025-07-27

Semaglutide lowers body weight in rodents via distributed neural pathways

Sanaz Gabery, Casper G. Salinas, Sarah J. Paulsen, Jonas Ahnfelt-Rønne, Tomas Alanentalo, Arian F. Baquero, Stephen T. Buckley, Erzsébet Farkas, Csaba Fekete, Klaus S. Frederiksen, Hans Christian C. Helms, Jacob F. Jeppesen, Linu M. John, Charles Pyke, Jane Nøhr, Tess T. Lu, Joseph Polex-Wolf, Vincent Prevot, Kirsten Raun, Lotte Simonsen, Gao Sun, Anett Szilvásy-Szabó, Hanni Willenbrock, Anna Sech

https://www.huntington-research.lu.se/semaglutide-lowers-body-weight-rodents-distributed-neural-pathways - 2025-07-27

Research Day 2019

Every year in November, the Faculty of Medicine at Lund University, together with the health care organization Region Skåne and the Eric K. Fernström Foundation, organize the Research Day in Malmö and Lund. This is an opportunity for the public to listen to researches presenting topical research. Each year has its own theme and in 2019 mental illness was the topic for the event, with talks, discus

https://www.huntington-research.lu.se/research-day-2019 - 2025-07-27

Highlights

2023 Knut and Alice Wallenberg Foundation has in cooperation with Åsa Petersén produced a short film about Huntington's disease and Petersén's research on HD. Link to the movie "Huntington's disease - the hunt for treatment" on YouTube The European Huntington Disease Network (EHDN) elected Åsa Petersén member of the executive committee. The EHDN is a nonprofit research network committed to advanci

https://www.huntington-research.lu.se/highlights - 2025-07-27

Imbalance of the oxytocin-vasopressin system contributes to the neuropsychiatric phenotype in the BACHD mouse model of Huntington disease

Cheong RY, Tonetto S, von Hörsten S and Petersén Å. Psychoneuroendocrinology 119, 104773 (2020) Abstract Neuropsychiatric disturbances with altered social cognition, depression and anxiety are among the most debilitating early features in the fatal neurodegenerative disorder Huntington disease (HD) which is caused by an expanded CAG repeat in the huntingtin gene. The underlying neurobiological mec

https://www.huntington-research.lu.se/imbalance-oxytocin-vasopressin-system-contributes-neuropsychiatric-phenotype-bachd-mouse-model - 2025-07-27

Recognition and Homosexuality: The Socio-Cultural Status of Same-Sex Relations in India and Vietnam

PhD Candidate: Maria ToniniAbstract: This project wishes to fill a gap in our knowledge about the socio-cultural status of female and male homosexuals (i.e. lesbians and gays) in contemporary India and Vietnam. The study will bring into dialogue current debates on recognition, rights, gender, and sexuality with the experiences of homosexuals in New Delhi and Hanoi. In contextualizing homosexual wo

https://www.gender.lu.se/research-2/research-projects-department/doctoral-projects/recognition-and-homosexuality-socio-cultural-status-same-sex-relations-india-and-vietnam - 2025-07-27

En öppen akademi

Projektet En öppen akademi är en satsning från Centrums sida på att utveckla en forskningsprofil kring makt, jämställdhet och mångfald inom akademin, utifrån feministiska, postkoloniala och queera perspketiv. Inom ramen för detta projekt är vi del av fakultetens forskningsstrategiska satsning, under titeln I Hedda Anderssons fotspår, samt del av Lunds universitets satsning på Equal opportunities.

https://www.gender.lu.se/en-oppen-akademi - 2025-07-27

Accessibility Statement_OLD

Accessibility of huntington-research.lu.se This website is run by the research group Translational Neuroendocrinology. We want as many people as possible to be able to use this website, and this document describes how huntington-research.lu.se complies with the accessibility regulations, any known accessibility issues, and how you can report problems so that we can fix them. How accessible is hunt

https://www.huntington-research.lu.se/accessibility-statementold - 2025-07-27

Hypothalamic overexpression of mutant huntingtin causes dysregulation of brown adipose tissue

Soylu-Kucharz R1, Adlesic N1, Baldo B1, Kirik D2 and Petersén Å1.1Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Sweden.2Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S.) Unit, Department of Experimental Medical Sciences Lund University, Sweden.Sci Rep. Sep 30;5:14598 (2015)AbstractExpression of mutant huntingtin (htt) protein has

https://www.huntington-research.lu.se/hypothalamic-overexpression-mutant-huntingtin-causes-dysregulation-brown-adipose-tissue - 2025-07-27

Landing page

Åsa Petersén - clinician scientist Important paper on Huntington disease by Gabery et al in Acta Neuropathologica 2021 TNU research The Translational Neuroendocrine Research Unit (TNU) focuses on Huntington’s disease (HD) and the spectrum of amyotrophic lateral sclerosis (ALS) and the behavioural variant of frontal temporal dementia (bvFTD).These are fatal neurodegenerative disorders without effec

https://www.huntington-research.lu.se/landing-page - 2025-07-27

Proteolytic degradation of neuropeptide Y (NPY) from head to toe: Identification of novel NPY-cleaving peptidases and potential drug interactions in CNS and Periphery

Wagner L1,2,3, Wolf R2, Zeitschel U4, Rossner S4, Petersén Å5, Leavitt BR6, Kästner F7, Rothermundt M7,8, Gärtner UT2, Gündel D9, Schlenzig D3, Frerker N10, Schade J10, Manhart S2, Rahfeld JU1,3, Demuth HU3 and von Hörsten S10.1Deutschsprachige Selbsthilfegruppe für Alkaptonurie (DSAKU) e.V., Stuttgart, Germany.2Probiodrug AG, Halle, Germany.3Fraunhofer-Institute for cell therapy and immunology, D

https://www.huntington-research.lu.se/proteolytic-degradation-neuropeptide-y-npy-head-toe-identification-novel-npy-cleaving-peptidases-and - 2025-07-27

Team

Our team of highly skilled staff has long experience in translational research. Visit us Find your way to us in Lund. Åsa Petersén Group leader, Professor Email: Asa [dot] Petersen [at] med [dot] lu [dot] se Telephone: +46 46 222 16 86 Sanaz Gabery Guest researcher Email: Sanaz [dot] Rasoly_Gabery [at] med [dot] lu [dot] se Sofia Bergh PhD student Email: Sofia [dot] Bergh [at] med [dot] lu [dot] s

https://www.huntington-research.lu.se/team - 2025-07-27