BACKGROUND: The high prevalence of mixed phenotypes of Early Onset Ataxia (EOA) with comorbid dystonia has shifted the pathogenetic concept from the cerebellum towards the interconnected cerebellar motor network. This paper on EOA with comorbid dystonia (EOA-dystonia) explores the conceptual relationship between the motor phenotype and the cortico-basal-ganglia-ponto-cerebellar network.METHODS: In

Many predictive models exist that predict risk of common cardiometabolic conditions. However, a vast majority of these models do not include genetic risk scores and do not distinguish between clinical risk requiring medical or pharmacological interventions and pre-clinical risk, where lifestyle interventions could be first-choice therapy. In this study, we developed, validated, and compared the pe

The aim of this paper is to reflect on the conceptualization of three, a priori, similar territorial innovation models: the triple helix, the regional innovation systems and Sábato’s triangle. To compare their underlying theoretical foundations, we conduct a bibliometric analysis of the contributions based on the previous territorial innovation models. Following Reinert’s procedure we identify the

Despite election violence being a commonly agreed upon phenomena in the Philippines, there has been a dearth in academic research on the topic in recent years, largely due to a lack of reliable information. To address this, our article adapts recognized methods from studies such as Lindsay Shorr Newman’s 2013 paper, together with Stephen McGrath and Paul Gill’s 2014 research on terrorism and elect

Stockholm Swedish has a distinction between so-called big accents and small accents (in addition to a lexical contrast between tone accent 1 and tone accent 2). The function and distribution of the big versus small accent has never been fully understood. West Germanic languages lack a corresponding distinction. While it is known that big accents appear on information-structural focus, this fact ca

This article focuses on Buddhism and resilience in the recovery process following the 2004 Boxing Day tsunami in Thailand. It is based on an anthropological study and deals with how the disaster was handled on a local level and gives examples of Buddhist practices and counselling. The article emphasizes Thai Buddhist monks’ and nuns’ interactions with the survivors and Buddhism’s capacity to stren

”Öppna köksskåpet där borta!” Därinne dolde sig en påbörjad insamling av ett unikt källmaterial. Materialet består av de första prästvigda kvinnornas berättelser om hur deras väg till prästvigning och de första åren i Svenska kyrkans tjänst sett ut. Berättelserna ger en bild av en levd erfarenhet som hittills inte varit känd men som är avgörande för förståelsen av Svenska kyrkan under 1900-talet,

Frida Mannerfelt och Alexander Maurits berättar utifrån boken ”Kallelse och erkännande – berättelser från de första prästvigda kvinnorna i Svenska kyrkan” (Makadam förlag) om det unika källmaterial med 34 av de första prästvigda kvinnorna som de har fått tillgång till och som har lett fram till den här boken. I breven framkommer berättelser om vägen fram till prästvigning och de första åren i förs

Children with type 1 diabetes (T1D) are at increased risk of celiac disease (CD). The replacement of insulin in T1D, and the exclusion of gluten in CD, are lifelong, burdensome treatments. Compliance to a gluten-free diet (GFD) in children with CD is reported to be high, while compliance in children with both diseases has scarcely been studied. To examine compliance to a GFD in children with both

Pediatric obsessive-compulsive disorder (OCD) clusters around three major symptom dimensions: contamination/cleaning, symmetry/ordering, and disturbing thoughts/checking. The Obsessive-Compulsive Inventory-Child Version (OCI-CV) is a self-report questionnaire that provides scores along six theory-based OCD dimensions, but no study has evaluated how well OCI-CV identifies clinically significant sym

CRC is one of the most common causes of cancer death in the world. If CRC is diagnosed in the early stages, the patient's chance of survival is estimated at about 90%, with a very low probability of recurrence. The five-year DFS for CRC patients in stage III and IV drops to 63.3% and 18.9%, respectively. The current thesis aimed to identify potential new prognostic and predicting biomarkers for th

Based on extensive ethnographic fieldwork in Uzbekistan, this article looks at the way official state narratives are challenged by silent, unorganized, often unawares, gestures of resistance at the bottom of a society. Footing on a framework suggested by Scott’s definition of infrapolitics (2012), we propose to incorporate informal practices in a definition of informality that is more inclusive, a

The ability to remember an episode from our past is often hindered by competition from similar events. For example, if we want to remember the article a colleague recommended during the last lab-meeting, we may need to resolve interference from other article recommendations from the same colleague. This study investigates if the contextual features specifying the encoding episodes are incidentally

BACKGROUND: Heparin-binding protein (HBP) is a neutrophil-derived pro-inflammatory protein, an inducer of endothelial dysfunction and vascular permeability and a promising prognostic biomarker in sepsis. This exploratory study aims to describe the kinetics of plasma HBP during septic shock and investigate an association between repeated measures of HBP concentration and cardiovascular organ dysfun

Sepsis causes major morbidity and mortality worldwide. There is wide consensus that biomarkers have an important role in sepsis research and patient care. Heparin-binding protein (HBP) is a neutrophil-derived, proinflammatory and vascular permeability-inducing protein and a promising novel sepsis biomarker. In this thesis, we investigate some aspects of the prognostic accuracy and added value of s

In recent years, techniques such as Bayesian inference of phylogeny have become a standard part of the quantitative linguistic toolkit. While these tools successfully model the tree-like component of a linguistic dataset, real-world datasets generally include a combination of tree-like and nontree-like signals. Alongside developing techniques for modeling nontree-like data, an important requiremen

Objectives This study aimed to explore multidimensional operationalizations of precarious employment (PE) in Swedish register data using two approaches: (i) a typological approach and (ii) a dimensional, summative scale approach. It also examined the distribution of sociodemographic and occupational characteristics of precarious employees in Sweden. Method Register data was retrieved on individual

Atmospheric inversion approaches are expected to play a critical role in future observation-based monitoring systems for surface fluxes of greenhouse gases (GHGs), pollutants and other trace gases. In the past decade, the research community has developed various inversion software, mainly using variational or ensemble Bayesian optimization methods, with various assumptions on uncertainty structure