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https://www.microscopy.lu.se/form/sign-miclu-email-list - 2025-05-03

Research Infrastructures and Initiatives Examples of research infrastructures of high relevance for the CIPA community, at Lund University and elsewhere (external links):InfraVisInfraVis@LUMBioQIMMAX IVESSNAISSLUNARCThrough the National Academic Infrastructure for Super­computing in Sweden (NAISS) and the Lund University centre for scientific and technical computing (LUNARC), CIPA users can apply

https://www.microscopy.lu.se/cipa/resources - 2025-05-03

Events 2024Dec 4: CIPA drop-in session at Forum MedicumVenue: BMC:E11075 Snilleblixten, Forum Medicum, Sölvegatan 19, LundWelcome to our drop-in session for help with Image Analysis!09.45-10.00  Coffee & mingle10.00-10.10  Welcome & tomographic imaging – Emanuel Larsson10.10-10.20  GUI development & spectroscopic imaging – Carl Troein10.20-10.30  Machine learning applied to images – Alexandros Sop

https://www.microscopy.lu.se/welcome-cipa/events-and-workshops - 2025-05-03

Kajsa M Paulsson, Head of unit/directorCIPA was initiated and is headed by Kajsa M Paulsson. While leading her research group at Experimental Medical Science, Kajsa has in parallel built a reputation and competence in management of Research Infrastructures. She has, for example, been a board member of a number of Swedish and European Research Infrastructures and initiatives. She is also an acknowl

https://www.microscopy.lu.se/welcome-cipa/cipa-staff - 2025-05-03

InfraVis is a Swedish national Research Infrastructure for data visualization. InfraVis helps you visualize research data from any scientific domain and gives you access to state-of-the-art visualization competence, support, equipment, training, and methods. InfraVis@LU is the InfraVis node for Visualisation and Analysis at Lund University, coordinated by CIPA.   InfraVis provides advanced visuali

https://www.microscopy.lu.se/cipa/infravislu - 2025-05-03

ServicesCryoEM at Lund University has a sample preparation lab installed with Mark IV Vitrobot (Thermo Fisher) to prepare cryo grids. Samples can be prescreened by a negative stain, and the cryo grids can be shipped to SciLifeLab or other facilities. In the beginning of 2025 there will also be a state of the art Glacios2 cryo electron microscope with a direct electron detector Falcon4i in our faci

https://www.microscopy.lu.se/cryoem-life-sciences-lund-university - 2025-05-03

Welcome to contact one of our experts! Crispin Hetherington Crispin’s background is transmission electron microscopy in materials science. In his various job positions in microscope user facilities, he gained a wide experience of different samples and of microscopy techniques including high resolution and aberration correction in TEM and STEM.  His present role in nCHREM now mainly involves operat

https://www.microscopy.lu.se/single-particle-cryoem-0/cryoem-applications-experts - 2025-05-03

Lotta Happonen I work as a researcher at the Faculty of Medicine studying protein-protein complexes arising at the host-pathogen interface, with the aim of understanding how pathogens evade the human immune defence. The main methods we are using are quantitative and structural mass spectrometry (cross-linking and hydrogen-deuterium exchange) in combination with single-particle cryo-EM. Since its s

https://www.microscopy.lu.se/single-particle-cryoem-0/cryoem-infrastructure-stakeholders - 2025-05-03

https://www.protein-chemistry.lu.se/protein-chemistry-group - 2025-05-03

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö. The group is focused on the complement system in health and disease. Our ambition is to make high quality basic science based on clinically relevant questions and yielding novel diagnostic approaches and clinical interventions. Our research is su

https://www.protein-chemistry.lu.se/anna-blom-research-group-0 - 2025-05-03

The Medical Protein Chemistry research group headed by prof. Anna Blom is located at the Wallenberg Laboratory within Skåne University Hospital in Malmö.  The group is focused on the complement system in health and disease. The complement, crucial part of innate immune system is involved in many basic biological processes such as defence against infections but when activated in a wrong place or no

https://www.protein-chemistry.lu.se/protein-chemistry-research-group - 2025-05-03

Best publications from our group over past years. The Library in Dublin. King B.C., Kulak K, Krus U., Rosberg R., Golec E., Wozniak K., Gomez M.F., Zhange E., O'Connell D., Renström E. and Blom A.M. (2019) Complement C3 proteinst against autophagy related beta-cell detah via ATG16L1 interaction and regulation of autophagy.., Cell Metabolism, 29, 202-210. Holmquist E., Bartoschek M., Reitsma B., Ja

https://www.protein-chemistry.lu.se/top-publications - 2025-05-03

List of selected publications from our research group exemplifying the projects we are conducting. The group in Madrid at Complement Worshop Blom. A. M., Pertoft H. and Fries E. (1995) Inter-a-inhibitor is required for the formation of the hyaluronan-containing coat on fibroblasts and mesothelial cells. J. Biol. Chem., 270, 9698-9701. Blom A. M., Mörgelin M., Öyen M., Jarvet J. and Fries E. (1999)

https://www.protein-chemistry.lu.se/top-publications/selected-publications-group - 2025-05-03

In blood, complement proteins are a major component and perhaps therefore most of these were identified already decades ago. However, only in recent years it has become apparent that complement not only plays a major role in innate defense against pathogens but also identifies foreign materials and removes waste (immune complexes and dying cells). The physiological relevance of complement is demon

https://www.protein-chemistry.lu.se/projects - 2025-05-03

We are studying an unexpected role of complement – in the physiology and metabolism of pancreatic beta-cells. Surprisingly, this is related to intracellular functions of complement and therefore changes the way we perceive this “blood” system and will likely inspire discovery of many other intracellular effects of complement. We study the role of intracellular complement factor C3 and membrane bou

https://www.protein-chemistry.lu.se/projects/insulin-and-immunity-when-complement-takes-control - 2025-05-03

As a first line of defense against pathogens and a mediator between innate and adaptive immunity, complement is a particular focus of evasion strategies developed by pathogens.  We showed that one common strategy is to bind complement inhibitor C4BP, which leads to decreased opsonisation of bacteria with C3b impairing phagocytosis and allowing bacterial survival. It appears that binding of C4BP is

https://www.protein-chemistry.lu.se/projects/bacterial-complement-evasion-strategies - 2025-05-03

  Myriam Martin, Rebecca Trattner and Anna Blom Misguided or excessive complement activation is involved in many common diseases such as rheumatoid arthritis, systemic lupus erythematosus, vasculitis and age-related macula degeneration. In collaboration with clinicians we are studying molecular mechanisms of complement involvement in these diseases. Joint inflammation in rheumatoid arthritis (RA),

https://www.protein-chemistry.lu.se/projects/pathologic-complement-activation-diseases - 2025-05-03

Expression of COMP in breast cancer tissue Complement-dependent cytotoxicity is one of the mechanisms by which therapeutic monoclonal antibodies are toxic to cancer cells. Also, complement is currently undergoing re-appreciation of its role in the immune surveillance of tumors. The majority of human tumors are low immunogenic and complement may be involved in their recognition via direct “danger s

https://www.protein-chemistry.lu.se/projects/complement-and-cancer - 2025-05-03

Complement has recently gained substantial worldwide attention, as it was discovered that several common diseases such as age-related macular degeneration (blindness in elderly) are related to deregulation of the balance between complement activation and inhibition. Full complement deficiencies lead to severe infectious and autoimmune diseases but are uncommon while it appears that we are just beg

https://www.protein-chemistry.lu.se/projects/inherited-deficiencies-complement-inhibitors - 2025-05-03

Myriam Martin, Rebecca Trattner and Anna Blom  You can reach us by mailor by calling 040-33 78 30 and 040-33 15 20Vaishnavi Dandavate, postdoctoral fellowE-mail: vaishnavi [dot] dandavate [at] med [dot] lu [dot] sePia Ecke, undergraduate studentE-mail: Pia [dot] Ecke [at] med [dot] lu [dot] seAlexander Ekström, PhD studentE-mail: alexander [dot] ekstrom [at] med [dot] lu [dot] se (alexander[dot]ek

https://www.protein-chemistry.lu.se/members-our-research-group - 2025-05-03