Microsoft Word - SCC CRISPR Facility presents v2.docx SCC CRISPR Facility presents: CRISPR Seminar Series Short talks about current use of CRISPR technology and the research outcomes. Tuesday October 8th 2019, 15:00-16.00, Segerfalksalen, BMC A10 Speakers: 15.00 Malin Åkerblom – Arrayed high content CRISPR screen in overlapping pools. Molecular Neuromodulation, Dept. of Experimental Medical Scienc

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/crispr_seminar_oct_8.pdf - 2025-07-19

pnas201305623 1..10 TFEB-mediated autophagy rescues midbrain dopamine neurons from α-synuclein toxicity Mickael Decressaca,1, Bengt Mattssona, Pia Weikopb, Martin Lundblada, Johan Jakobssona, and Anders Björklunda,1 aDepartment of Experimental Medical Sciences, Wallenberg Neuroscience Center, Lund University, 22184 Lund, Sweden; and bLaboratory of Neuropsychiatry, Rigshospitalet University Hospita

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/decressac_et_al._pnas_2013.pdf - 2025-07-19

_ © 2014. Published by The Company of Biologists Ltd | Development (2014) 141, 1-9 doi:10.1242/dev.101659 1 ABSTRACT New neurons, originating from the subventricular zone, are continuously integrating into neuronal circuitry in the olfactory bulb (OB). Using a transgenic sensor mouse, we found that adult-born OB interneurons express microRNA-125 (miR-125), whereas the pre- existing developmentally

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/development-2014-akerblom.pdf - 2025-07-19

let‐7 regulates radial migration of new‐born neurons through positive regulation of autophagy Article let-7 regulates radial migration of new-born neurons through positive regulation of autophagy Rebecca Petri, Karolina Pircs, Marie E Jönsson, Malin Åkerblom, Per Ludvik Brattås, Thies Klussendorf & Johan Jakobsson* Abstract During adult neurogenesis, newly formed olfactory bulb (OB)

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/embj.201695235.full_.pdf - 2025-07-19

Functional studies of microRNAs in neural stem cells: problems and perspectives REVIEW ARTICLE published: 07 February 2012 doi: 10.3389/fnins.2012.00014 Functional studies of microRNAs in neural stem cells: problems and perspectives Malin Åkerblom1,2, Rohit Sachdeva1,2 and Johan Jakobsson1,2* 1 Laboratory of Molecular Neurogenetics, Department of Experimental Medical Science, Wallenberg Neuroscien

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/fnins-06-00014.pdf - 2025-07-19

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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/hanna_sabelstrom.pdf - 2025-07-19

The Journal of Clinical Investigation R E S E A R C H A R T I C L E 1jci.org Introduction Our capacity to perform well-coordinated movements depends on the activity of 2 pathways linking the striatum with deep basal ganglia nuclei. The direct pathway originates from striatal neurons project- ing monosynaptically to the output nuclei of the basal ganglia (i.e., the globus pallidus pars interna and

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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/pircs.pdf - 2025-07-19

Impact of differential and time-dependent autophagy activation on therapeutic efficacy in a model of Huntington disease Full Terms & Conditions of access and use can be found at https://www.tandfonline.com/action/journalInformation?journalCode=kaup20 Autophagy ISSN: (Print) (Online) Journal homepage: https://www.tandfonline.com/loi/kaup20 Impact of differential and time-dependent autophagy activat

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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_cell_reports_1.pdf - 2025-07-19

Turning skin into dopamine neurons RESEARCH HIGHLIGHT Turning skin into dopamine neurons Malin Parmar1, Johan Jakobsson1 1Department of Experimental Medical Science, Wallenberg Neuroscience Center, and Lund Stem Cell Center, Lund University, SE- 221 84 Lund, Sweden Cell Research advance online publication 9 August 2011; doi:10.1038/cr.2011.130 Cell Research (2011) :1-2. © 2011 IBCB, SIBS, CAS All

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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_epilepsy_research_0.pdf - 2025-07-19

doi:10.1016/j.yexcr.2004.04.037 www.elsevier.com/locate/yexcr Experimental Cell Research 298 (2004) 611–623 Dynamics of transgene expression in a neural stem cell line transduced with lentiviral vectors incorporating the cHS4 insulator Johan Jakobsson, Nina Rosenqvist, Lachlan Thompson, Perrine Barraud, and Cecilia Lundberg* Wallenberg Neuroscience Center, Department of Physiological Sciences, Lun

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https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_heliyon.pdf - 2025-07-19

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_immunity.pdf - 2025-07-19

The Krüppel-associated Box Repressor Domain Can Trigger de Novo Promoter Methylation during Mouse Early Embryogenesis*□S Received for publication, July 18, 2007, and in revised form, September 24, 2007 Published, JBC Papers in Press, September 24, 2007, DOI 10.1074/jbc.M705898200 Maciej Wiznerowicz‡§1, Johan Jakobsson‡§2, Jolanta Szulc‡, Shunyao Liao‡§, Alexandra Quazzola‡§, Friedrich Beermann‡¶,

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The Journal of Clinical Investigation R e s e a R c h a R t i c l e 1jci.org Introduction Upon inflammation, an array of brain-mediated responses occurs. They are collectively referred to as the sickness syndrome and include fever, decreased food intake, inactivity, social withdrawal, and corticosteroid secretion (1, 2). These objective symptoms are accompanied by feelings of malaise and discomfor

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Targeted transgene expression in rat brain using lentiviral vectors Targeted Transgene Expression in Rat Brain Using Lentiviral Vectors Johan Jakobsson,* Cecilia Ericson, Maria Jansson, Elin Björk, and Cecilia Lundberg Wallenberg Neuroscience Center, Department of Physiological Science, Lund University, Lund, Sweden Direct gene transfer to the adult brain is dependent on vectors that transduce no

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LINE-2 transposable elements are a source of functional human microRNAs and target sites RESEARCH ARTICLE LINE-2 transposable elements are a source of functional human microRNAs and target sites Rebecca Petri1, Per Ludvik BrattåsID 1, Yogita Sharma1, Marie E. JönssonID 1, Karolina PircsID 1, Johan Bengzon2, Johan JakobssonID 1* 1 Laboratory of Molecular Neurogenetics, Department of Experimental M

https://www.molecular-neurogenetics.lu.se/sites/molecular-neurogenetics.lu.se/files/publication_in_plos_genet.pdf - 2025-07-19