Critical functions of the immune system are maintained by the ability of myeloid progenitors to differentiate and mature into macrophages. We hypothesized that the cytoprotective gas molecule carbon monoxide (CO), generated endogenously by heme oxygenases (HO), promotes differentiation of progenitors into functional macrophages. Deletion of HO-1, specifically in the myeloid lineage (Lyz-Cre:Hmox1(

Correct diagnosis and staging are required for optimal treatment choice in lung cancer patients. This retrospective, patient medical records study investigated the clinical practice of lung cancer biopsy procedures and testing in Sweden.

The response of electric devices to an applied thermal gradient has, so far, been studied almost exclusively in two-terminal devices. Here we present measurements of the response to a thermal bias of a four-terminal, quasiballistic junction with a central scattering site. We find a novel transverse thermovoltage measured across isothermal contacts. Using a multiterminal scattering model extended t

Popular Abstract in Swedish Jordens totala energiförbrukning stiger. Samtidigt förbrukas primärt fossila naturresurser som kan anses ändliga, så som olja, kol eller naturgas, för att tillgodose energibehovet. Även andra energikällor används, t.ex. kärnbränsle, vind och vatten. Denna avhandling fokuserar på energi som omvandlas vid förbränning av gas i gasturbiner. Eftersom naturgas är ett fossilt In this thesis, the effect of alternative gaseous fuels, with high hydrogen content and lower calorific value, on gas turbine combustion was investigated experimentally. The aim of the investigation was to find operational limitations for an experimental burner and to supply data for validation of computational fluid dynamics (CFD). Before examination of the actual burner, the laminar flame speed

Nano-sized (10(-9)-10(-7) m) particles offer many technical and biomedical advances over the bulk material. The use of nanoparticles in cosmetics, detergents, food and other commercial products is rapidly increasing despite little knowledge of their effect on organism metabolism. We show here that commercially manufactured polystyrene nanoparticles, transported through an aquatic food chain from a

Using a simplified model for in-medium dipole evolution accounting for color filtering effects we study the production of hadrons at large transverse momenta p(T) in heavy ion collisions. In the framework of this model, several important sources of the nuclear suppression observed recently at RHIC and LHC have been analyzed. A short production length of the leading hadron l(p) causes a strong onse

Objectives The aim of this pilot study was to investigate cause(s) of heart failure (HF). Setting The emergency department and medical wards at Malmo University Hospital. Method A cross sectional pilot study. Main outcome measures Comparison of compliance, comprehension and optimal treatment on a population basis between men and women, younger (a parts per thousand currency sign75 years) and elder

The role of sulphur in the production of hydrogen in the small-scale for fuel cell applications is an important topic in the design of such systems and this review of the literature state-of-the-art has been performed to shed light on some of the possible trade-offs that will have to be done in designing these systems. The review-paper summarises the literature with respect to sulphur-laden cataly

Peritoneal dialysis involves diffusive and convective transports and osmosis through the highly vascularized peritoneal membrane. The capillary endothelium offers the rate-limiting hindrance for solute and water transport. It can be functionally described in terms of a three-pore model including transcellular, ultrasmall pores responsible for free-water transport during crystalloid osmosis. Severa

Due to the unavailability of culture-appropriate measurements of health-related quality of life (HRQOL) in China, knowledge about the HRQOL of women with cervical cancer, particularly in Mainland China, is poor. Such knowledge is greatly needed to inform nursing practice. Thus the main aim of this thesis was to investigate longitudinally the HRQOL trajectory in Chinese women from when cervical can

Increased snow depth already observed, and that predicted for the future are of critical importance to many geophysical and biological processes as well as human activities. The future characteristics of sub-arctic landscapes where permafrost is particularly vulnerable will depend on complex interactions between snow cover, vegetation and permafrost. An experimental manipulation was, therefore, se

Popular Abstract in Swedish Endokrina och metabola sjukdomstillstånd har många gemensamma komponenter. Att förstå de signalvägar som ligger till grund för dessa sjukdomar hjälper oss att utveckla bättre behandlingsmetoder. Det övergripande syftet med min forskning är att undersöka den roll s.k. G-protein kopplade receptorer spelar i endokrina metaboliska sjukdomar, mer specifikt de signalvägar somThe aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug

A key to successful chronic neural interfacing is to achieve minimal glial scarring surrounding the implants, as the astrocytes and microglia may functionally insulate the interface. A possible explanation for the development of these reactions is mechanical forces arising between the implants and the brain. Here, we show that the difference between the density of neural probes and that of the tis

This article explores the symbolic aspects of change agency on a learning platform designed to facilitate system-wide transformation in cancer care. A sensemaking-sensegiving perspective is adopted to analyse the construction of meaning amongst of the leader of a regional cancer centre, senior physicians and an action research team in relation to patient-centred care. The analysis suggests that th

FTIR imaging was performed on pig ear skin samples cryo-sectioned perpendicular to the skin surface. The OH-stretch region revealed the distribution of water; the amide II band gave the protein distribution; the C=O stretch and C-H stretch regions showed the variation in lipids. Water and proteins were similarly distributed. Triglycerides were predominantly found in the deeper skin layers whereas

This paper discusses compact node-link formulations for MPLS fast reroute optimal single path layout. We propose mathematical formulations for MPLS fast reroute local protection mechanisms. In fact, we compare one-to-one (also called detour) local protection and many-to-one (also called facility backup) local protection mechanisms with respect to minimized maximum link utilization. The optimal res

Background: Sacroiliitis in ankylosing spondylitis has frequently been graded radiographically using the New York (NY) criteria, which also have been applied in computed tomography (CT). Purpose: To validate the grading of the NY criteria in CT of the sacroiliac joints. Material and Methods: With the aid of the NY criteria, assessment of inflammatory and degenerative changes was made in 1304 CT st

By discussing Sophie Leijonhufvud’s Swedish translation of Dinah Mulock’s A Woman’s Thoughts about Women (1858, transl. 1861) this article investigates how the agenda of the translator and editor may affect the target text, for instance by altering the implied reader and by assuming an additional authorial voice.

Et konferenspaper som belyser de centrala delarna av min kommande avhandling där effekter av långvarig arbetslöhset och socialbidragsbehov hos unga med omfattande arbetsmarkandsproblematik alltsedan 1990-talet belyses.Texten visar på den omfattande skam och och ovilja till socialbidragsberoende studiens respondenter uttrycker.