Proteinopathy, defined as the abnormal accumulation of proteins that eventually leads to cell death, is one of the most significant pathological features of neurodegenerative diseases. Tauopathies, represented by Alzheimer’s disease (AD), and synucleinopathies, represented by Parkinson’s disease (PD), show similarities in multiple aspects. AD manifests extrapyramidal symptoms while dementia is als

Milk is a nutrient-dense fluid which is essential for a healthy balanced diet. Thermal processing is the dominating approach in the dairy industry to ensure food safety, however, heat treatment can alter both the composition and quality of the milk. The aim of this thesis has been to evaluate the effects of various processing technologies on the nutrient content and physical properties of milk and

The ice phenology of alpine lakes on the Tibetan Plateau (TP) is a rapid and direct responder to climate changes, and the variations in lake ice exhibit high temporal frequency characteristics. MODIS and passive microwave data are widely used to monitor lake ice changes with high temporal resolution. However, the low spatial resolutions make it difficult to effectively quantify the freeze-melt dyn

Recognising the need for objective imaging-based technologies to assess wound healing in clinical studies, the suction blister wound model offers an easily accessible wound model that creates reproducible epidermal wounds that heal without scarring. This study provides a comprehensive methodology for implementing and evaluating photography-based imaging techniques utilising the suction blister wou

This paper uses longitudinal establishment-level data to trace the rise of the factory during Sweden's industrialization between 1864 and 1890. We document a sharp shift from the small artisan shop to the mechanized factory, which can largely be ascribed to differences in survival. Whilst non-mechanized establishments could compete with the factory during early industrialization, a distinct surviv

Context. The age, evolution, and chemical properties of the Galactic disk can be effectively ascertained using open clusters. Within the large program Stellar Populations Astrophysics at the Telescopio Nazionale Galileo, we specifically focused on stars in open clusters, to investigate various astrophysical topics, from the chemical content of very young systems to the abundance patterns of lesser

A key element for successful blood transfusion is compatibility of the patient and donor red blood cell (RBC) antigens. Precise antigen matching reduces the risk for immunization and other adverse transfusion outcomes. RBC antigens are encoded by specific genes, which allows developing computational methods for determining antigens from genomic data. We describe here a classification method for de

Background and aims: Endoscopic retrograde cholangiopancreatography (ERCP) procedures can result in significant patient radiation exposure. This retrospective multicenter study aimed to assess the influence of procedural complexity and other clinical factors on radiation exposure in ERCP. Methods: Data on kerma-area product (KAP), air-kerma at the reference point (Ka,r), fluoroscopy time, and the

Context. To be able to investigate the chemical history of the entire Milky Way, it is imperative to also study its dust-obscured regions in detail, as this is where most of the mass lies. The Galactic Center is an example of such a region. Due to the intervening dust along the line of sight, near-infrared spectroscopic investigations are necessary to study this region of interest.Aims. The aim of

Experimentation has been considered critical for successful software product and business development, including in video game startups. Video game startups need “wow” qualities that distinguish them from the competition. Thus, they need to continuously experiment to find these qualities before running out of time and resources. In this study, we aimed to explore how these companies perform experi

Objective: To investigate the feasibility of using neutron tomography to gain new knowledge of human articular cartilage degeneration in osteoarthritis (OA). Different sample preparation techniques were evaluated to identify maximum intra-tissue contrast. Design: Human articular cartilage samples from 14 deceased donors (18–75 years, 9 males, 5 females) and 4 patients undergoing total knee replace

Harp seals (Phoca groenlandicus), once present in the Baltic Sea, now stand extinct. During the Middle Neolithic period, they held significant dietary importance for the Pitted Ware Culture hunter-fisher-gatherers in Scandinavia. Because they are no longer available for ecological studies, little is known about their specific behavioural intricacies, such as diet, mobility, and reproductive strate

Objective: Interactive patient education, referred to as Heart School (HS), is an important part of cardiac rehabilitation (CR) after myocardial infarction (MI), which has been associated with improved outcomes. Little is known about HS attendance among foreign-born patients. The aims were to assess; 1) HS attendance in foreign-born versus native-born patients, 2) the association between the provi

The anomalous Lagrangian in mesonic Chiral Perturbation Theory, of odd intrinsic parity, is determined to next-to-next-to-leading order thereby completing the order p8 Lagrangian. A schematic view of its construction with the MINIBAR package for Mathematica is presented and the final operator count is discussed for a general number of light quark flavours as well as for the physical cases N f = 2,

Divergent ecological adaptation resulting from selection is common, but how often it results in differentiation that can last in the face of gene flow is debated. Reproductive barriers persistent to stochastic environmental change are key for species to form. Hence, how ecological adaptation is coupled to reproductive isolation is key for understanding ecological speciation. Lineages that are both

Articular cartilage and meniscus transfer and distribute mechanical loads in the knee joint. Degeneration of these connective tissues occurs during the progression of knee osteoarthritis, which affects their composition, microstructure, and mechanical properties. A deeper understanding of disease progression can be obtained by studying them simultaneously. Time-resolved synchrotron-based X-ray pha