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Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising

The average transverse momentum (p(T)) versus the charged-particle multiplicity N-ch was measured in p-Pb collisions at a collision energy per nucleon-nucleon root S-NN = 5.02 TeV and in pp collisions at collision energies of root s = 0.9, 2.76, and 7 TeV in the kinematic range 0.15 < p(T) < 10.0 GeV/c and vertical bar eta vertical bar < 0.3 with the ALICE apparatus at the LHC. These data are comp

The absence of compassion, argues the author, is not the cause of healthcare failures but rather a symptom of deeper systemic failures. The clinical encounter arouses strong emotions of anxiety, fear, and anger in patients which are often projected onto the clinicians. Attempts to protect clinicians through various bureaucratic devices and depersonalization of the patient, constitute as Menzies no

Objective. To investigate alterations of tumor necrosis factor (TNF)-, interleukin (IL)-6, the Notch/Jagged signaling pathway, and hepatocyte proliferation, and their correlation in rats subjected to partial hepatectomy. Material and methods. Blood and liver tissues were sampled immediately (0), 5, 15, 30, 60, 180, 360, and 720 min, and 1, 2, 4, and 7 days after partial (70%) hepatectomy to measur

Gift exchange, and the economy associated with it, is not restricted only to those tribal cultures where it has mostly been studied, but can also appear as an element of contemporary market economies. Yet despite this, the practical functioning of gift relationships between business partners is an understudied area. By studying the giving of corporate Christmas gifts, this article contributes to c

Acute lung injury (ALI) is an inflammatory disease with a high mortality rate. Although typically seen in individuals with sepsis, ALI is also a major complication in severe acute pancreatitis (SAP). The pathophysiology of SAP-associated ALI is poorly understood, but elevated serum levels of IL-6 is a reliable marker for disease severity. Here, we used a mouse model of acute pancreatitis–associate

A preparation method for silver-oxide containing nanoparticles is described. The suggested approach allows varying the oxidation degree from monoxide to an oxygen-rich state resembling superoxide The method is based on magnetron reactive sputtering and vapour aggregation, and utilizes silver-oxygen interaction in the vapour phase - prior to the nanoparticle aggregation from the vapour. Synchrotron

The formation of iron aluminide (FeAl) during the heating of Fe-40 at.% Al powder mixture has been studied using a differential scanning calorimeter. The effect of particle size of the reactants, compaction of the powder mixtures as well as the heating rate on combustion behavior has been investigated. On heating compacted discs containing relatively coarser iron powder, DSC data show two consecut

The inclusive top quark pair (t (t) over tilde) production cross-section sigma(t (t) over bar) has been measured in proton-proton collisions at root s = 7 TeV and root s = 8 TeV with the ATLAS experiment at the LHC, using t (t) over bar events with an opposite-charge e mu pair in the final state. The measurement was performed with the 2011 7 TeV dataset corresponding to an integrated luminosity of

The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two

Sedimentary records of invertebrate assemblages were obtained from a small lake in the Khibiny Mountains, Kola Peninsula. Together with a quantitative chironomid-based reconstruction of mean July air temperature, these data provide evidence of Holocene climate variability in the western sector of the Russian Subarctic. The results suggest that the amplitude of climate change was more pronounced in

Until now inscriptions have confirmed that the quarries of Gebel el Silsila East were in use until the time of Emperor Tiberius, but recent findings indicate that the quarrying process continued for at least another two generations. In one of the many smaller quarries three men carved their name repeatedly on the quarry walls, and dated their visits to a four year period, between the sixth and ten

Background Patients who have suffered from tuberculosis are at risk of respiratory failure with hypercapnea from chest wall deformity and hypoxia from pulmonary sequelae. The combination of hypercapnea and hypoxia justifies both mechanical ventilation and oxygen therapy as treatment options. We aimed to study which treatment mode is associated with the best survival in patients with the combinatio

The article is an analysis of the Okupatsioonide Museum, The Museum of the Occupations, in Tallinn, Estonia. The analysis deals both with the content of the exhibition as well as well as the monuments of former Communists in its basement, It alse deals with "the power of place", the location of the museum and its importance in Tallinn´s "cityscape".