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New Information Systems Development Methodologies (ISDMs) are suggested in the belief that their deployment would be beneficial to consultants in their work. A large number of ISDMs already exist but their value has been questioned and at the same time new methodologies continue to be introduced in an attempt to support and improve the practice of information systems development work. What is not

Early cybernetics emphasized control and communication in the animal and the machine. Subsequent understandings of linguistic phenomena in the animal have shown them not to be reducible to purely mechanistic models. The linguistic complementarity, with its possibilities for transcendence, provides such an understanding, indicating relativistic approaches within modern systems theory. Comparisons a

Traditional high level synthesis is able to yield high computational resource utilisation and short critical paths. The shortcomings of the generated designs usually lies in the memory architecture. To achieve good performance on a FPGA, the data must reside in the fast on-chip memories, but these are commonly too small for the data being processed. Traditional high level synthesis cannot cope wit

The way in which the cortical cytoskeleton associates to the plasma membrane (PM) must be elucidated to understand the structural dynamics of many processes in the plant cell. In the present study, isolated cauliflower (Brassica oleracea L.) PM vesicles were used to characterize membrane/cytoskeleton interactions. Both actin and tubulin were shown to copurify with PM vesicles and this copurificati

Popular Abstract in Swedish I världen beräknas det finnas cirka 38 miljoner blinda människor enligt Värdshälsoorganisationen (WHO). Av dessa är 1,5 miljon barn under 16 år. Blindhet definieras av WHO som bästa korrigerade synskärpa under 0,05 (man klarar således inte att läsa översta raden på en vanlig synprövningstavla på halva normalavståndet), detta med bästa glasögonkorrektion och med båda ögoKnowledge of the epidemiology of visual impairment in children forms one of the cornerstones in paediatric ophthalmology. To gain an overview of the situation in Sweden an epidemiological study was performed. Totally 2373 visually impaired children were found, giving an age-specific prevalence of 10,9/10 000. Childhood blindness (i.e. vision <0,05) was seen in 25%. Male/female ratio was 1,20. Addi

Popular Abstract in Swedish De allra flesta människor har vid något tillfälle tagit ett läkemedel. Till exempel vaccineras nu för tiden alla svenska barn mot bland annat stelkramp. Vad nog de allra flesta däremot inte har gjort är att fundera på vad ett läkemedel är. Kanske sträcker man sig till att ha kollat upp ett läkemedel i FASS, och kanske får man då syn på en figur som består av streck och A method to accurately estimate the binding affinity of a small molecule to a receptor would be indispensable in numerous fields. For instance, most drugs exert their action by binding to a macromolecule target. Thus, a lot of time and resources could be saved in drug design by predicting affinities by computer programs. In a series of 15 papers, we have tested, compared, and improved the most p