Background: A growing evidence base supports the use of autologous haematopoietic stem cell transplantation (aHSCT) for treatment of relapsing-remitting multiple sclerosis (RRMS), but it has not yet been integrated into most national clinical guidelines. The objective of this study was to assess efficacy and safety when aHSCT is implemented in routine healthcare. Methods: We assessed 231 patients

Fire has the potential to create significant impacts on the built environment. Managing this impact is sometimes pursued without consideration of the interface between the natural and technological worlds. However, as society has recognized the impacts of technological development on environmental sustainability, the need for sustainable and resilient development has emerged. To facilitate sustain

Background: Respiratory virus infections are main triggers of asthma exacerbations. Tezepelumab, an anti-TSLP mAb, reduces exacerbations in patients with asthma, but the effect of blocking TSLP on host epithelial resistance and tolerance to virus infection is not known. Aim: To examine effects of blocking TSLP in patients with asthma on host resistance (IFNβ, IFNλ, and viral load) and on the airwa

Background and purpose — Antibiotic-loaded bone cement (ALBC) and systemic antibiotic prophylaxis (SAP) have been used to reduce periprosthetic joint infection (PJI) rates. We investigated the use of ALBC and SAP in primary total knee arthroplasty (TKA). Patients and methods — This observational study is based on 2,971,357 primary TKAs reported in 2010–2020 to national/regional joint arthroplasty

An emissions barrier was used in premises with indoor air complaints due to emissions from the buildings in question. The emissions comprised chlorophenols/chloroanisoles and polycyclic aromatic hydrocarbons (PAH) from treated wood, volatile organic compounds (VOC) from PVC flooring and/or the glue used to paste the flooring onto a concrete slab, and radon from radium-containing aerated concrete.

Learning outcomes: This case study covers different concepts related to leadership. It should help students analyze business situations from a leader’s perspective. By the end of this case study, students would be able to understand the role and the characteristics of leadership during a crisis using the 11 dimensions of character framework, map leadership personalities using the HEXACO model to u

Measurements of the production of electrons from heavy-flavour hadron decays in pp collisions at s = 13 TeV at midrapidity with the ALICE detector are presented down to a transverse momentum (p T) of 0.2 GeV/c and up to p T = 35 GeV/c, which is the largest momentum range probed for inclusive electron measurements in ALICE. In p-Pb collisions, the production cross section and the nuclear modificati

A new, more precise measurement of the Λ hyperon lifetime is performed using a large data sample of Pb-Pb collisions at sNN=5.02 TeV with ALICE. The Λ and Λ¯ hyperons are reconstructed at midrapidity using their two-body weak decay channel Λ→p+π- and Λ¯→p¯+π+. The measured value of the Λ lifetime is τΛ=[261.07±0.37(stat.)±0.72(syst.)] ps. The relative difference between the lifetime of Λ and Λ¯, w

Average nucleotide identity analysis, based on whole genome sequences of 115 strains previously identified as Aerococcus urinae, an emerging uropathogen, discriminates at least six unique genomic taxa. The whole genome analysis affords clearer species boundaries over 16S rRNA gene sequencing and traditional phenotypic approaches for the identification and phylogenetic organization of Aerococcus sp

The transverse-momentum (pT) spectra and coalescence parameters B2 of (anti)deuterons are measured in p-p collisions at s=13 TeV for the first time in and out of jets. In this measurement, the direction of the leading particle with the highest pT in the event (pTlead>5 GeV/c) is used as an approximation for the jet axis. The event is consequently divided into three azimuthal regions, and the jet s

The azimuthal (Δ φ) correlation distributions between heavy-flavor decay electrons and associated charged particles are measured in pp and p–Pb collisions at sNN=5.02 TeV. Results are reported for electrons with transverse momentum 4 < pT< 16 GeV / c and pseudorapidity | η| < 0.6 . The associated charged particles are selected with transverse momentum 1 < pT< 7 GeV / c , and relative pseudorapidit

Cocaine and amphetamine-regulated transcript (CART) is expressed in pancreatic islet cells and neuronal elements. We have previously established insulinotropic actions of CART in human and rodent islets. The receptor for CART in the pancreatic beta cells is unidentified. We used RNA sequencing of Cartpt knockdown (KD) INS-1 832/13 cells and identified GPR162 as the most Cartpt-regulated receptor.

BACKGROUND: Very preterm infants often require respiratory support and are therefore exposed to an increased risk of chronic lung disease and later neurodevelopmental disability. Although methylxanthines are widely used to prevent and treat apnea associated with prematurity and to facilitate extubation, there is uncertainty about the benefits and harms of different types of methylxanthines.OBJECTI

Actual evapotranspiration (ETa) plays a crucial role in the water and energy cycles of the earth. An accurate estimate of the ETa is essential for management of the water resources, agriculture, and irrigation, as well as research on atmospheric variations. Despite the importance of accurate ETa values, estimating and mapping them remains challenging due to the physical and biological complexity o

Commencing from the question “what makes mysticism feminine?” (a medical-historical conception of female bodies being receptive to some forms of mystical experiences? following an idea of gendered embodiment, a specific feminine spiritual corporeality?), the presence of forms of violence preceding the beatification or sanctification of women as victim souls caught my attention.Examples like Laura