The technical development of high-throughput sequencing technologies and the parallel development of targeted therapies in the last decade have enabled a transition from traditional medicine to personalized treatment and care. In this way, by using comprehensive genomic testing, more effective treatments with fewer side effects are provided to each patient—that is, precision or personalized medici

The theme of ICIS 2013 in Milan is "Reshaping Society through Information Systems" (http://icis2013.aisnet.org/). One aspect of reshaping society that has been recently discussed in central Europe is that of social inclusion (http://ec.europa.eu/social/main.jsp?catId=750&langId=en). Yet, after decades of research and ambitious political programs, we still observe an imbalanced treatment toward

Over the last decade, social media environments have increasingly become an attractive research setting for Information Systems researchers. However, the methodological implications of this research setting for IS studies, are still not fully understood. In this paper we develop and present a framework to reflect on a recent qualitative healthcare IS study that focussed on the use of social media

Over the past decade, there has been increasing interest in the use of grounded theory in information systems research. Grounded theory is a qualitative research method that seeks to develop theory that is grounded in data systematically gathered and analysed. The purpose of this paper is to suggest guidelines for grounded theory studies in information systems. Our guidelines are based on a framew

This article investigates the emergence and early use of possessive HAVEgot in English. Two hypotheses about its emergence are tested on historical data (c.1460–1760). One hypothesis is based on communicative functionality, suggesting that got was inserted as a ‘pattern preserver’ to compensate for the increased reduction of HAVE. The other hypothesis invokes the conventionalization of an invited This article investigates the emergence and early use of possessive havegot in English. Two hypotheses about its emergence are tested on historical data (c.1460–1760). One hypothesis is based on communicative functionality, suggesting that got was inserted as a ‘pattern preserver’ to compensate for the increased reduction of have. The other hypothesis invokes the conventionalization of an invited

Introduction: In spite of societal efforts to strengthen women's sexual and reproductive health in Sweden, many women have unmet contraceptive needs and the abortion rate remains high. The aim of this study was to investigate contraceptive use among abortion-seeking women. Material and methods: Swedish-speaking women seeking an induced abortion up to the end of gestational week 12 at seven hospita

Criteria for diagnosing atrial blockade, which is manifested on the electrocardiogram by lengthening and changing the morphology of wave P, are examined. The prognostic value of far-reaching atrial blockade as a predictor of the development of supraventricular arrhythmias and embolic stroke is discussed.

The use of protective gloves is of importance in workplaces where hazardous chemicals are handled, including the chemical industry, the plastic industry, as well as in environments such as dental practices, hairdressing, and beauty salons. Occupational dermatology can provide crucial advice regarding how to avoid or protect the patient against allergens found in the work environment and provide th

The production of prompt Λc+ baryons has been measured at midrapidity in the transverse momentum interval 0

Among thermal improvements of external walls in heritage buildings, interior insulation of external walls might be the only option. However, interior insulation is associated with several risks of damage due to the diminishment of the hygrothermal performance of the existing wall. This project aims to assess the impact of available solutions for interior insulation through field measurements and h

Chiral compounds containing nitrogen heteroatoms are fundamental substances for the chemical, pharmaceutical and agrochemical industries. However, the preparation of some of these interesting scaffolds is still underdeveloped. Herein we present the synthesis of a family of P-stereogenic phosphinooxazoline iridium catalysts from L-threonine methyl ester and their use in the asymmetric hydrogenation

Background: Behavioural symptoms and frontotemporal hypometabolism overlap between behavioural variant of frontotemporal dementia (bvFTD) and primary psychiatric disorders (PPD), hampering diagnostic distinction. Voxel-wise comparisons of brain metabolism might identify specific frontotemporal-(hypo)metabolic regions between bvFTD and PPD. We investigated brain metabolism in bvFTD and PPD and its

The prevalence of thyroid antibodies, indicating an autoimmune thyroiditis, has been shown to be significantly increased in patients with autoimmune diseases. A 3-year prospective follow-up study of 42 patients with biopsy-confirmed glomerulonephritis is presented. Although the majority of patients had been treated with immunosuppressants, the prevalence of thyroid peroxidase antibodies was unchan

Extracorporeal shock wave lithotripsy (ESWL) has become a useful tool in the treatment of renal calculi, but side effects may occur. Hitherto, two case reports have been published of an anti-glomerular basement membrane disease resulting in end-stage renal failure following ESWL treatment. In this prospective study of 59 consecutive patients undergoing ESWL for renal calculi, the prevalence of aut

In a time when protectionism is re-emerging as a strong policy stance on a global scale, the opposition to cross mergers based on public interest grounds may once more become more frequent. The lack of a common policy at the EU level leaves each Member State free to set its own framework to oppose mergers based on the public interest. However, such frameworks need to comply with Article 4(1)(b) of

Chronological age is an important independent predictor of cardiovascular events. Although the cumulative effect of cardiovascular risk factors over time partly explains this relationship, accumulating evidence suggests this is a simplistic interpretation of a more complex concept. With advancing age slowly progressive changes can be seen affecting the structure and function of large and small ves

International non-governmental organisations (NGOs) combine practical and advocacy efforts to address global challenges like poverty and climate change. However, NGOs are embedded within the same global system they seek to challenge. This article explore the tensions this raises from the vantage point of one particular organisation (Concern Universal). Drawing on a paradox perspective, we find tha