Preeclampsia is a leading cause of pregnancy complications and affects 3-7% of pregnant women. This review summarizes the current knowledge of a new potential etiology of the disease, with a special focus on hemoglobin-induced oxidative stress. Furthermore, we also suggest hemoglobin as a potential target for therapy. Gene and protein profiling studies have shown increased expression and accumulat

Permanent uppehållstillstånd är en förutsättning för att kunna planera ett liv. Det bör ges så fort som möjligt för att flyktingen ska kunna bygga en trygg framtid. En längre tids osäkerhet skapar marginalisering som är svår att bryta.

Apolipoprotein A-I (apoA-I) is the main protein of high-density lipoprotein (HDL) and a principal mediator of the reverse cholesterol transfer pathway. Variants of apoA-I have been shown to be associated with hereditary amyloidosis. We previously characterized the G26R and L178H variants that both possess decreased stability and increased fibril formation propensity. Here we investigate the Milano

The aim of this study was to evaluate the effect of increasing the amount of time spent in physical education classes on bone mineral accrual and gain in bone size in prepubertal Danish children. A total of 135 boys and 108 girls, aged 6-8 years, were included in a school-based curriculum intervention program where the usual time spent in physical education classes was doubled to four classes (180

New tetrahydrothiophene derivatives, which are demonstrated to be reactive towards various nucleophiles and provide access to [b]- and [c]-fused sulfolenes are described. Application of heterocyclic sulfides as o-quinodimethane precursors is documented. (C) 2013 Elsevier Ltd. All rights reserved.

We study the rate of Bayesian consistency for hierarchical priors consisting of prior weights on a model index set and a prior on a density model for each choice of model index. Ghosal, Lember and Van der Vaart [2] have obtained general in-probability theorems on the rate of convergence of the resulting posterior distributions. We extend their results to almost sure assertions. As an application w

Development of robust yeast strains that can efficiently ferment lignocellulose-based feedstocks is one of the requirements for achieving economically feasible bioethanol production processes. With this goal, several genes have been identified as promising candidates to confer improved tolerance to S. cerevisiae. In most of the cases, however, the evaluation of the genetic modification was perform

We propose an energy-based framework for approximating surfaces from a cloud of point measurements corrupted by noise and outliers. Our energy assigns a tangent plane to each (noisy) data point by minimizing the squared distances to the points and the irregularity of the surface implicitly defined by the tangent planes. In order to avoid the well-known "shrinking" bias associated with first-order

(Co/Au) and (Au/ Co/ Au) nanomagnet arrays grown on nanostructured self-organized SiGe templates have been characterized by means of x-ray photoemission electron microscopy, x-ray magnetic circular dichroism, and by extended x-ray absorption spectroscopy using synchrotron radiation. In-plane magnetization is observed at room temperature for practically all Co thicknesses, a stable macroscopic perp

Increasing the number of persons working on quality assurance (QA) tasks, e.g., reviews and testing, increases the number of defects detected – but it also increases the total effort unless effort is controlled with fixed effort budgets. Our research investigates how QA tasks should be configured regarding two parameters, i.e., time and number of people. We define an optimization problem to answer

Cloud drop condensation nuclei (CCN) and ice nuclei (IN) particles determine to a large extent cloud microstructure and, consequently, cloud albedo and the dynamic response of clouds to aerosol-induced changes to precipitation. This can modify the reflected solar radiation and the thermal radiation emitted to space. Measurements of tropospheric CCN and IN over large areas have not been possible an

Popular Abstract in Swedish Ductus arteriosus är ett kärl som finns hos foster för att styra blodet förbi lungorna. Kärlet stänger sig normalt inom 3 dagar efter födelsen men kan kvarstå öppet framför allt hos mycket för tidigt födda barn. Vid födelsen leder tryckförändringar i cirkulationen till att flödet i ductus vänder och blodet styrs istället till lungorna. Flödet genom ductus hos för tidigtThe aim of this thesis was to develop a non-invasive method to quantify the size of a shunt through a patent ductus arteriosus (PDA) by ultrasound and to test its usability in clinical settings. There is no consensus regarding the optimal management strategy for a PDA in premature infants. Non-steroidal anti-inflammatory drugs (NSAID) are the first treatment of choice. The use of NSAIDs, especiall

Factor I (FI) is a crucial inhibitor controlling all complement pathways due to its ability to degrade activated complement proteins C3b and C4b in the presence of cofactors such as factor H, C4b-binding protein, complement receptor 1 or CD46. Complete deficiency of FI, which is synthesized mainly in the liver is rare and leads to complement consumption resulting in recurrent severe infections, gl

Background. The SWENOTECA IV protocol from 1995 is a prospective population-based study in metastatic non-seminomatous germ cell testicular cancer (NSGCT), designed for early identification of patients with poor response to standard cisplatin-based chemotherapy. A slow tumor marker decline (HCG T(1/2) > 3 days, AFP T(1/2) > 7 days) after BEP or BEP plus ifosfamide was regarded as poor response. Th

Measurements of cross sections for events with charm and beauty jets in deep inelastic scattering at HERA are presented. Events with jets of transverse energy E-T(jet) > 6 GeV and pseudorapidity - 1.0 < eta(jet) < 1.5 in the laboratory frame are selected in the kinematic region of photon virtuality Q(2) > 6 GeV2 and inelasticity variable 0.07 < y < 0.625. Measurements are also made requiring a jet

Henning M., Stam E. and Wenting R. Path dependence research in regional economic development: cacophony or knowledge accumulation, Regional Studies. The concept of path dependence has gained momentum in the social sciences, particularly in economic geography. This paper explores the empirical literature on path dependence and path creation in regional economic development. It offers a critical ref

Background. Linear programming has been used extensively as a tool for nutritional recommendations. Extending the methodology to food formulation presents new challenges, since not all combinations of nutritious ingredients will produce an acceptable food. Furthermore, it would help in implementation and in ensuring the feasibility of the suggested recommendations. Objective. To extend the previou