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We study the design of efficient approximation algorithms for the ℓ-center clustering and minimum-diameter ℓ-clustering problems in high-dimensional Euclidean and Hamming spaces. Our main tool is randomized dimension reduction. First, we present a general method of reducing the dependency of the running time of a hypothetical algorithm for the ℓ-center problem in a high-dimensional Euclidean space
Jeffrey Breau of Harvard University and Natalie Bloch, Research Fellow at Lund University, discuss how psychedelic experiences are interpreted within religious traditions, with particular attention to Judaism and the emergence of new psychedelic churches in the United States.Their conversation explores how these experiences are shaped by cultural frameworks and by ongoing debates between perennial
A blood group may be defined as an inherited character of the red cell surface detected by a specific alloantibody. This definition would not receive universal acceptance, since cell surface antigens on platelets and leucocytes might also be considered blood groups (see Chapter 4), as might acquired characteristics on red cells defined by autoantibodies or polyagglutinins. The definition is suitab
Spin crossover (SCO) complexes are highly promising candidates for a myriad of potential applications in room-temperature electronics; however, as it stands, establishing a clear connection between their spin-state switching and transport properties has been far from trivial. In this perspective, an effort to unravel the underlying charge transport mechanism in these SCO complexes, via a general t
Traumatic brain injury and stroke often result in contralateral sensorimotor deficits, including asymmetric posture. While these lateralized effects are classically attributed to neural tract disruption, recent evidence supports the existence of a complementary humoral pathway. Our previous work demonstrated that the neurohormone Arg-vasopressin (AVP) mediates right hindlimb responses to left-side
Background: Adolescents are increasingly using classical psychedelics, yet little is known about how psychedelics use is related to their mental health. Emerging evidence suggests that adolescents may be more vulnerable to adverse outcomes in relation to psychedelic use compared to adults. This descriptive and exploratory study examined differences between adolescents and adults in reported psyche
The demand for safe and durable modified-wood products is increasing in the construction sector. In this work, the in situ wet-chemistry synthesis of a glassy MgO/Na2O–SiO2 solid in Scots pine (Pinus sylvestris L.) sapwood via a two-stage impregnation process using an industrial timber-impregnation autoclave is reported. Magnesium sulphate heptahydrate (MgSO4·7H2O), a historic fire retardant, and
Rickard Länta är renskötare i Jåhkågasska sameby i den svenska delen av Sápmi. Hans renbetesmarker är starkt påverkade av projekt såsom skogsavverkning, vattenkraft, infrastrukturutveckling och turism. Därtill har det kontroversiella gruvprojektet i Gállok, som också är beläget i detta område, godkänts av den svenska regeringen och Högsta domstolen. Denna artikel bygger på ett samtal där Rickard bRickard Länta is a reindeer herder in Jåhkågasska reindeer herding community in Swedish administered Sápmi. The land in which his reindeer are migrating has already been impacted by projects such as deforestation, hydropower, infrastructure development, and tourism. In addition, the controversial Gállok mining project, which is also located in this land, has been approved by the Swedish government
Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an
In situ synthesis of oestrogens is of great importance in the development and progression of breast cancer. 17β-hydroxysteroid dehydrogenase (17HSD) type 2 catalyses oxidation from oestradiol to oestrone, and thereby protects the breast epithelial cells from oestradiol. Low expression of 17HSD type 2 has been associated with decreased survival in breast cancer, but no studies have investigated the
BACKGROUND AND PURPOSE: The breast cancer susceptibility genes BRCA1 and BRCA2 interact with Rad51, one of the central components in the homologous recombination repair pathway. This study evaluates the prognostic and predictive role of BRCA1, BRCA2 and Rad51, individually and as a complex, in breast cancer.MATERIALS AND METHODS: Expression of BRCA1, BRCA2 and Rad51 was investigated using immunohi
Female-producing parthenogenesis is widespread in stick insects. It ranges from rare in sexual species to facultative or obligate, the latter sometimes in hybrids. This review synthesizes current knowledge on its origins, mechanisms, and evolutionary consequences, highlighting the distinction between hybrid and intra-specific origins. Hybrid-derived parthenogens are rare, obligate, frequently poly
Background Severe exacerbations (SevEx), the typical endpoint when evaluating asthma therapies, may provide incomplete assessment, as it relies on patient perception of disease and physician action. CompEx, a composite outcome that includes SevEx and acute worsening events (AWEs) (evaluated from e-diary entries using deterioration in peak expiratory flow (PEF), reliever medication use and worsenin
This practice-based research employs sculptural and sound practices, and their mediation through representation, notation, technologies and performance, to develop an innovative compositional process named co-composition, in which physical and sonic material can be concurrently produced, rearranged and transformed.\nAt the core of this thesis is a multi-layered mode of thinking, informed by an und
Purpose: To investigate the expression and predictive role of the Mre11/Rad50/Nbs1 (MRN) complex and the ataxia-telangiectasia mutated protein (ATM) for the outcome of radiotherapy in breast cancer patients. Methods and Materials: The protein expression of ATM and the DNA repair proteins in the MRN complex were investigated using immunohistochemistry in tumors from 224 women with early breast canc
