The active site of sulfite reductase (SiR) consists of an unusual siroheme–Fe4S4 assembly coupled via a cysteinate sulfur, and serves for multi-electron reduction reactions. Clear explanations have not been demonstrated for the reasons behind the choice of siroheme (vs. other types of heme) or for the single-atom coupling to an Fe4S4 center (as opposed to simple adjacency or to coupling via chains

We introduce a method for taking microscopic limits of normal matrix ensembles and apply it to study the behaviour near certain types of singular points on the boundary of the droplet. Our investigation includes ensembles without restrictions near the boundary, as well as hard edge ensembles, where the eigenvalues are confined to the droplet. We establish in both cases existence of new types of de

Objective: Steady state insulin-like growth factor-1 (IGF-1) levels vary significantly during continuous intravenous infusion of recombinant human insulin-like growth factor-1/recombinant human insulin-like growth factor binding protein-3 (rhIGF-1/rhIGFBP-3) in the first weeks of life in extremely preterm infants. We evaluated interleukin-6 (IL-6) and insulin-like growth factor binding protein-1 (

Ekonomistyrning för offentliga verksamheter ger en introduktion till ämnet ekonomistyrning och hur kommuner och regioner arbetar med ekonomisk styrning och ekonomiska styrmodeller. Boken inleds med att ge en introduktion till ämnet ekonomistyrning, vad ekonomistyrning är och hur kommuner och regioner styrs. Därefter behandlas ekonomistyrningens olika delar och modeller samt hur de används eller ka

This paper focuses on the specific problems in the labour and social security legislation as it relates to crowdworkers in the digitalizes new economy, analyzing their place in labour market, and especially in the collective agreements which are the standard means of regulating working conditions in the Nordic model. Sweden has a binary system where a performing party is as either an employee or s

This study investigates the growth in global renewable energy use between 2000 and 2014. To identify its main contributors and their geographical distribution, a structural decomposition analysis is applied to global multi-regional input-output tables. A new variant of this type of analysis is developed that introduces energy transition (i.e. the substitution of non-renewable energy by renewable e

The measurement of the deuteron and anti-deuteron production in the rapidity range −1

This Letter presents direct searches for lepton flavour violation in Higgs boson decays, H→eτ and H→μτ, performed with the ATLAS detector at the LHC. The searches are based on a data sample of proton–proton collisions at a centre-of-mass energy s=13 TeV, corresponding to an integrated luminosity of 36.1 fb−1. No significant excess is observed above the expected background from Standard Model proce

New military technologies are animated by fantasies of perfect knowledge, lawfulness, and vision that contrast sharply with the very real limits of human understanding, law, and vision. 'War and Algorithm' look at the increasing power of algorithms in these emerging forms of warfare from the perspectives of critical theory, philosophy, legal studies, and visual studies. Together, the contributions

Apart from the consistently observed differential association between obesity and breast cancer risk by menopausal status, the associations between obesity and other metabolic imbalances with risks of cancers have not been systematically investigated across the age-course. We created two random 50–50% cohorts from six European cohorts comprising 813,927 individuals. In the “discovery cohort”, we u

Growing research focusing on the psychological reactions to terrorism by citizens finds that terrorist attacks perpetrated by individuals belonging to Muslim minorities increase nega- tive attitudes towards those perceived as the ”outgroup”, and especially immigrants and refugees. However, few attempts have been made so far to assess the short-term impact of these attacks. While we know that immed

This paper focuses on how multiple actors promote civic and political participation of immigrants locally. The dominant approach in scholarship on political participation of immigrants —the political opportunity structure—focuses mostly on the role of local institutional actors to examine the constraints and opportunities for immigrants’ civic and political participation. We argue that this main f

Innovations affect urban and rural areas differently. Although thesupply chain management (SCM) literature recognises the interaction betweenurban and rural areas in terms of flow of products, people and communication,the rural perspective is clearly missing. An inductive approach was appliedusing an interdisciplinary panel of international experts to explore challengesand opportunities in the int

Childhood vaccination has been promoted as a global intervention aimed at improving child survival and health, through the reduction of vaccine preventable deaths. However, there exist significant inequalities in achieving universal coverage of child vaccination among and within countries. In this paper, we examine rural-urban inequalities in child immunizations in Ghana. Using data from the recen

Atrial natriuretic peptide (ANP) represents an attractive therapeutic target in hypertension and heart failure. The biologically active form of ANP is produced by the cardiac serine protease corin, and modulation of its activity might therefore represent a novel approach for ANP augmentation. MicroRNAs (miRNAs) are pervasive regulators of gene expression, but their potential role in regulating cor

Background: Hyperlipidaemia is a major risk factor for cardiovascular disease, and atherosclerosis is the underlying cause of both myocardial infarction and stroke. We have previously shown that the Pro251 variant of perilipin-2 reduces plasma triglycerides and may therefore be beneficial to reduce atherosclerosis development. Objective: We sought to delineate putative beneficial effects of the Pr

Objectives There is an epidemic of Mesoamerican nephropathy (MeN) in Central America, where sugarcane production is prominent. Numerous causes are proposed, but to date limited evidence supports any one hypothesis. A nested case-control study using biosamples from a rural, community-based follow-up study of 350 young adults from Northwest Nicaragua at risk of MeN was conducted with the aim of char