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Epilepsy is a chronic neurological disorder marked by recurrent seizures, significantly impacting individuals worldwide. Current treatments are often ineffective for a third of patients and can cause severe side effects, necessitating new therapeutic approaches. Glial cells, particularly astrocytes, microglia, and oligodendrocytes, are emerging as crucial targets in epilepsy management. Astrocytes
Aims: An explainable advanced electrocardiography (A-ECG) Heart Age gap is the difference between A-ECG Heart Age and chronological age. This gap is an estimate of accelerated cardiovascular aging expressed in years of healthy human aging, and can intuitively communicate cardiovascular risk to the general population. However, existing A-ECG Heart Age requires sinus rhythm. We aim to develop and pr
Background Water retention, ultrafiltration insufficiency, and metabolic complications due to abnormally high glucose concentrations are still common problems in patients treated with peritoneal dialysis. Phloretin, a nonselective inhibitor of facilitative glucose transporter channels (GLUT), has shown to improve water transport and lower glucose absorption in experimental peritoneal dialysis. How
Aim: To explore the meaning of adaptation after visceral transplantation in terms of patient experiences, symptoms, self-efficacy, transplant-specific and mental well-being. Design: A convergent parallel mixed-methods study, consisting of interviews and generic as well as transplant-specific questionnaires. Results were integrated using meta-inference. Methods: The study comprises a population of
Quantum technologies and experiments often require preparing systems in low-temperature states. Here we investigate cooling schemes using feedback protocols modeled with a quantum Fokker-Planck master equation (QFPME) recently derived by Annby-Andersson et al. [Phys. Rev. Lett. 129, 050401 (2022)0031-900710.1103/PhysRevLett.129.050401]. This equation describes systems under continuous weak measure
We report on the discovery and spectroscopic confirmation of TOI-2458 b, a transiting mini-Neptune around an F-type star leaving the main-sequence with a mass of M∗ = 1.05 ± 0.03 M⊙, a radius of R∗ = 1.31 ± 0.03 R⊙, an effective temperature of Teff = 6005 ± 50 K, and a metallicity of 0.10 ± 0.05 dex. By combining TESS photometry with high-resolution spectra acquired with the HARPS spectrograph, we
Objectives: We aimed to describe the cardiopulmonary function during exercise and the health-related quality of life (HRQoL) in patients with a history of COVID-19 pneumonia, stratified by chest computed tomography (CT) findings at baseline. Methods: Among 77 consecutive patients with COVID-19 who were discharged from the Pulmonology Ward between March 2020 and April 2021, 28 (mean age 54.3 ± 8.6
Atrial fibrillation and heart failure have both been suggested to increase stroke and dementia risk. However, in observational studies, reversed causation and unmeasured confounding may occur. To mitigate these issues, this study aims to investigate if higher genetic risk for atrial fibrillation and heart failure increases dementia and stroke risk. Data were obtained from the population-based Goth
Objective: Progressive Supranuclear Palsy (PSP) is a severe neurodegenerative disease characterized by tangles of hyperphosphorylated tau protein and tufted astrocytes. Developing treatments for PSP is challenging due to the lack of disease models reproducing its key pathological features. This study aimed to model sporadic PSP-Richardson's syndrome (PSP-RS) using multi-donor midbrain organoids (M
The EU AI Act aims to regulate artificial intelligence (AI) in a way that balances innovation and protection from harms, but faces the challenge of keeping pace with the development of AI. This paper examines the tension between fixity and flexibility when regulating AI in the EU by drawing on literature on the pacing problem and anticipatory governance, contrasted by sociolegal theory on the impo
Chest pain is one of the most common reasons for emergency department (ED) visits. Extensive diagnostic testing is often performed to identify acute coronary syndrome (ACS), but only about 10% of patients ultimately receive an ACS diagnosis. These diagnostic processes are costly, time-consuming, and sometimes invasive, carrying inherent risks. Additionally, most patients with suspected ACS are adm
This paper deals with the centroid and formation control problem of multi–agent robotic systems. The proposed solution is based on a leader–follower scheme, where only a subset of agents, i.e., the leaders, knows the desired trajectories for the centroid and the formation of the system, while the other agents, i.e., the followers, are required to estimate them through a dynamic consensus scheme. T
Continuous experimentation (CE) is a software development approach where product decisions are data-driven. Large global internet-facing companies such as Microsoft, Google, and Facebook apply the practice by leveraging their massive user bases to obtain high statistical significance in experimentation results. However, companies with smaller user bases, such as small- and medium-sized enterprises
Using molten salts for etching aluminum (Al) away from the MAX phase for MXene synthesis is an attractive alternative method that allows one to avoid the use of toxic hydrofluoric acid (HF) solutions. However, the mechanism of the MAX phase reaction with molten salts remains to date unclear due to the lack of in situ data. Here, we present a detailed in situ time-resolved synchrotron radiation X-r
Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be
The minimal SO(10) grand unified theory, augmented by higher-dimensional operators, is based on the following Higgs representations: adjoint 45H, spinor 16H, and complex vector 10H. It was recently realized that, as opposed to the conventional wisdom, any intermediate mass scale has to lie close to the grand unification one. This bears profound consequences for the scalar particles mass spectrum a
