Sökresultat

Filtyp

Din sökning på "*" gav 535945 sökträffar

Protecting the Environment in Relation to Armed Conflict - The Role of Multilateral Environmental Agreements

This thesis examines how environmental treaties, also referred to as multilateral environmental agreements (MEAs), can enhance the protection of the environment during armed conflicts of both international and non-international character. The examination also covers the immediate aftermath of armed conflicts. Most of the previous research has focused on the application of the law of armed conflict

Distinct myeloid progenitor-differentiation pathways identified through single-cell RNA sequencing

According to current models of hematopoiesis, lymphoid-primed multi-potent progenitors (LMPPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)Flt3(hi)) and common myeloid progenitors (CMPs) (Lin(-)Sca-1(+)c-Kit(+)CD34(+)CD41(hi)) establish an early branch point for separate lineage-commitment pathways from hematopoietic stem cells, with the notable exception that both pathways are proposed to generate all myeloid

Prospective validation of two mathematical models to calculate the risk of endometrial malignancy in patients with postmenopausal bleeding and sonographic endometrial thickness ≥4.5 mm

AIM: To prospectively validate two mathematical models for calculating the likelihood of endometrial malignancy in patients with postmenopausal bleeding (PMPB), sonographic endometrial thickness (ET) ≥4.5 mm and no fluid in the uterine cavity.METHODS: This is a prospective observational diagnostic validation study performed in a PMPB clinic in a university hospital. Of 860 consecutive patients, 35

CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios : better diagnostic markers of Alzheimer disease

OBJECTIVE: The diagnostic accuracy of cerebrospinal fluid (CSF) biomarkers for Alzheimer's disease (AD) must be improved before widespread clinical use. This study aimed to determine whether CSF Aβ42/Aβ40 and Aβ42/Aβ38 ratios are better diagnostic biomarkers of AD during both predementia and dementia stages in comparison to CSF Aβ42 alone.METHODS: The study comprised three different cohorts (n = 1

I’m a lobbyist and I’m proud : – how lobbyists are communicating and negotiating their roles and identities in Brussels (Best paper award)

Lobbyists are working in an ambivalent atmosphere. In Brussels, lobbying is an activity occupying about 20 000 people on a daily basis. They are trying to influence the legislative outcomes from the work of the about 15 000 politicians and employees of the EU institutions (Coen 2007). On one hand the lobbyists are wanted and needed by the politicians and their civil servants. Previous research tel

Vertical Extension of Buildings as an Enabler of Energy Renovation

We report on the study of six similar buildings built in an area of Gothenburg, Sweden, in 1971, which are now in urgent need of renovation. However, the owner of the buildings - a municipal housing company did not achieve a financially viable renovation of the pilot project. This meant that renovation on a similar basis for the remaining five buildings would not be possible. For this reason the h

Anti-Müllerian hormone and fertility in male patients with chronic kidney disease

AbstractBoth men and women with end stage renal disease (ESRD) often suffer from infertility. The reason for this is multifactorial and includes sexual dysfunction, psychological factors and hormonal disturbances. The hypothalamic-pituitary gonadal axis is altered already at moderate reduction in kidney function. Hyperprolactinemia and testosterone deficiency due to Leydig cell impairment have bee

Nutritional strategies for skeletal and cardiovascular health : hard bones, soft arteries, rather than vice versa

The focus of this paper is to explore better strategies for optimising bone strength and reducing risk of fracture, while at the same time decreasing risk of cardiovascular disease. The majority of Americans do not consume the current recommended dietary allowance for calcium, and the lifetime risk of osteoporosis is about 50%. However, traditional mononutrient calcium supplements may not be ideal

Bivalirudin versus heparin in non-ST and ST-segment elevation myocardial infarction - A registry-based randomized clinical trial in the SWEDEHEART registry (the VALIDATE-SWEDEHEART trial)

Background The optimal anticoagulant for patients with acute coronary syndrome treated with percutaneous coronary intervention (PCI) has not been validated in current practice of radial approach and pretreatment with potent P2Y12 inhibitors. Several studies have indicated increased bleeding rate and, in some instances, even increased mortality by the routine use of heparin and glycoprotein IIb/III

Radioimmunotherapy of prostate cancer targeting human kallikrein-related peptidase 2

Background: Prostate cancer ranks as the second most lethal malignancy in the Western world. Previous targeting of prostate-specific antigen and human kallikrein-related peptidase 2, two related enzymes abundantly expressed in prostatic malignancies, with radioimmunoconjugates intended for diagnostic purposes, have proven successful in rodent prostate cancer (PCa) models. In this study, we investi

'Struggling to be a defender of health' -a qualitative study on the pharmacists' perceptions of their role in antibiotic consumption and antibiotic resistance in Romania

BACKGROUND: Antibiotic resistance is a serious global public health problem directly correlated to high antibiotic consumption. Romania is one of the European countries with the highest rates of antibiotic consumption, non-prescription antibiotics use and resistance of several pathogens to antibiotics. Pharmacists are an important stakeholder in respect to antibiotic management and context specifi

Surgery for patients with primary hyperparathyroidism and negative sestamibi scintigraphy--a feasibility study

BACKGROUND: We report the surgical treatment of a consecutive series of scan negative patients with the intention of unilateral parathyroid exploration with the aid of intraoperative quick PTH (qPTH).MATERIALS AND METHODS: The study included 35 consecutive sestamibi scan negative patients (27 women, eight men) with sporadic pHPT subjected to first time surgery. Median age was 70 years and median p

Multifractal analysis of some multiple ergodic averages

In this paper we study the multiple ergodic averages, on the symbolic space σm = (0,1,...,m-1}N* where m≥ 2, ℓ ≥ 2, q≥ 2 are integers. We give a complete solution to the problem of multifractal analysis of the limit of the above multiple ergodic averages. Actually we develop a non-invariant and non-linear version of thermodynamic formalism that is of its own interest. We study a large class of mea

Increased integrity of white matter pathways after dual n-back training

Dual n-back WM training has been shown to produce broad transfer effects to different untrained cognitive functions. The task is demanding to the cognitive system because it includes a bi-modal (auditory and visual) dual-task component. A previous WM training study showed increased white matter integrity in the parietal lobe as well as the anterior part of the corpus callosum after visual n-back t

Adult Education as a Heterotopia of Deviation : A Dwelling for the Abnormal Citizen

We argue that municipal adult education (MAE) can be seen as a place for displaced and abnormal citizens to gain temporary stability, enabling their shaping into desirable subjects. Drawing on a poststructural discursive analysis, we analyze policy texts and interviews with teachers and students. Our analysis illustrates how two distinct but interrelated student subjectivities are shaped: the root