I diskussionen om New Public Management och om hur mycket marknadsprinciper respektive professionerna ska styra offentlig sektor finns ytterligare en aspekt som förtjänar att lyftas fram, den nybyråkratiska logiken. Här har förvaltningen, med globaliseringen och EU-medlemskapet som drivkrafter, ökat ambitionsnivån på senare år. Inte minst i form av en allt starkare rättsstat, skriver docenten och

Over the past decade, avoiding deforestation has become a central element of the UN Framework Convention on Climate Change (UNFCCC). The focal point of this has been the incentive-based mechanism of REDD+, which stands for Reducing Emissions from Deforestation and forest Degradation. A key notion in REDD+ is to establish incentives for developing countries to reduce their forest-related carbon emi

Genetic studies of complex traits have become increasingly successful as progress is made in next-generation sequencing. We aimed at discovering single nucleotide variation present in known and new candidate genes for developmental dyslexia: CYP19A1, DCDC2, DIP2A, DYX1C1, GCFC2 (also known as C2orf3), KIAA0319, MRPL19, PCNT, PRMT2, ROBO1 and S100B. We used next-generation sequencing to identify si

BACKGROUND: Children with problematic severe asthma have poor disease control despite high doses of inhaled corticosteroids and additional therapy, leading to personal suffering, early deterioration of lung function, and significant consumption of health care resources. If no exacerbating factors, such as smoking or allergies, are found after extensive investigation, these children are given a dia

Single-nucleotide polymorphisms (SNPs) in GSDMB (Gasdermin B) and ORMDL3 (ORMDL sphingolipid biosynthesis regulator 3) are strongly associated with childhood asthma, but the molecular alterations contributing to disease remain unknown. We investigated the effects of asthma-associated SNPs on DNA methylation and mRNA levels of GSDMB and ORMDL3. Genetic association between GSDMB/ORMDL3 and physician

Osteoarthritis (OA) is the most common form of arthritis and often causes pain and functional impairment. Despite its high burden on society, knowledge about the occurrence of OA and its associated mortality is sparse. The epidemiology of OA is difficult to determine due to the patients’ fluctuating symptoms and challenges in detecting and defining the radiographic disease. The specific aims of th

Regulated transcription controls the diversity, developmental pathways and spatial organization of the hundreds of cell types that make up a mammal. Using single-molecule cDNA sequencing, we mapped transcription start sites (TSSs) and their usage in human and mouse primary cells, cell lines and tissues to produce a comprehensive overview of mammalian gene expression across the human body. We find

Vitamin D, PTH och kalcium i relation till Prostata Cancer

Recently, we proposed a design framework to obtain efficient and uncorrelated MIMO antennas in mobile handsets for frequencies below 1 GHz. The main benefit of the approach is that it can give significantly larger bandwidths than existing techniques. Using the Theory of Characteristic Modes, it has been shown that slightly modification of the chassis can result in multiple orthogonal resonant mode

BACKGROUND: Several studies have shown associations between blood lipid levels and the risk of atrial fibrillation (AF). To test the potential effect of blood lipids with AF risk, we assessed whether previously developed lipid gene scores, used as instrumental variables, are associated with the incidence of AF in 7 large cohorts.METHODS: We analyzed 64,901 individuals of European ancestry without