Wiehager S, Beiderbeck D, Gruber S, El Khoury A, Waamsteker J, Neumann I, Mathé A* and Petersén Å*.Neurobiology of Disease 34: 375-380 (2009) *equal contributionAbstractThe neurobiological bases of mood disorders remain elusive but both monoamines and neuropeptides may play important roles. The neuropeptide cocaine and amphetamine regulated transcript (CART) was shown to induce anxiety-like behavi

https://www.huntington-research.lu.se/increased-levels-cocaine-and-amphetamine-regulated-transcript-cart-two-animal-models-depression-and - 2025-07-25

Dupuis L, Petersen Å and Weydt P.Handbook of Clinical Neurology 157: 749-760 (2018)AbstractAmyotrophic lateral sclerosis (ALS) is the major adult-onset motor neuron disease, and is clinically, pathologically, and genetically associated with frontotemporal dementia, the second cause of dementia in the elderly. Here, we review the evidence linking thermoregulation and ALS. Indeed, while ALS is not c

https://www.huntington-research.lu.se/thermoregulation-amyotrophic-lateral-sclerosis - 2025-07-25

Pouladi M, Graham RK, Karasinska JM, Xie Y, Dar Santos R, Petersén Å, and Hayden MR1 Department of Medical Genetics, University of British Columbia, Vancouver, British Columbia, V6T 1Z3 Canada 2 Centre for Molecular Medicine and Therapeutics, Child and Family Research Institute, Vancouver, British Columbia, V5Z 4H4 Canada 3 Translational Neuroendocrine Research Unit, Department of Experimental Med

https://www.huntington-research.lu.se/prevention-depressive-behaviour-yac128-mouse-model-huntington-disease-mutation-residue-586 - 2025-07-25

Schultz K, Wiehager S, Nilsson K, Nielsen JE, Lindquist SG, Hjermind LE, Andersen BB, Wallin A, Nilsson CF and Petersén Å.Neuroscience Letters 453: 104-106 (2009)AbstractDementia with Lewy bodies (DLB) is the second most common form of neurodegenerative dementia after Alzheimer's disease (AD). The underlying neurobiological mechanism of DLB is not fully understood and no generally accepted biomark

https://www.huntington-research.lu.se/reduced-csf-cart-dementia-lewy-bodies - 2025-07-25

Petersén Å, Hult S and Kirik D.Neurodegenerative Diseases 6: 154-164 (2009)AbstractHuntington's disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Although it is characterized by progressive motor impairments, cognitive changes and psychiatric disturbances are major components of the disease. In addition, recent studies have shown that other non-m

https://www.huntington-research.lu.se/huntingtons-disease-new-perspectives-based-neuroendocrine-changes-rodent-models - 2025-07-25

Petersén Å and Lundberg L.Läkartidningen 106: 1273-1276 (2009)Link to the article (in Swedish)

https://www.huntington-research.lu.se/neuroleptic-malignant-syndrome-rare-diagnosis-high-mortality - 2025-07-25

Brundin L, Björkqvist M, Träskman-Bendz L and Petersén Å.Journal of Affective Disorders 113: 179-182 (2009)AbstractBACKGROUND:The orexins (hypocretins) and cocaine and amphetamine regulated transcript (CART) are hypothalamic peptides involved in the regulation of sleep and appetite. We have previously shown that levels of both orexin-A and CART in the cerebrospinal fluid (CSF) are related to speci

https://www.huntington-research.lu.se/increased-orexin-levels-cerebrospinal-fluid-first-year-after-suicide-attempt - 2025-07-25

Petersén Å, Wörtwein G, Gruber SH, El-Khoury A and Mathé AA.Neuroscience Letters 451(2): 148-151 (2009)AbstractA prevailing hypothesis is that neurogenesis is reduced in depression and that the common mechanism for antidepressant treatments is to increase it in adult hippocampus. Reduced neurogenesis has been shown in healthy rats exposed to stress, but it has not yet been demonstrated in depresse

https://www.huntington-research.lu.se/nortriptyline-mediates-behavioral-effects-without-affecting-hippocampal-cytogenesis-genetic-rat - 2025-07-25

Bode F, Stephan M, Suhling H, Pabst R, Straub RH, Raber KA, Bonin M, Nguyen HP, Riess O, Bauer A, Sjoberg C, Petersén Å and von Horsten S.Human Molecular Genetics 17(17): 2595-2609 (2008)AbstractRecent clinical studies have highlighted that female sex hormones represent potential neuroprotective mediators against damage caused by acute and chronic brain diseases. This evidence has been confirmed b

https://www.huntington-research.lu.se/sex-differences-transgenic-rat-model-huntingtons-disease-decreased-17-b-estradiol-levels-correlate - 2025-07-25

Petersén Å, Wörtwein G, Gruber S and Mathé A.Neuroscience letters 436(3): 305-308 (2008)AbstractHippocampal neurogenesis is potentially implicated in etiology of depression and as the final common mechanism underlying antidepressant treatments. However, decreased neurogenesis has not been demonstrated in depressed patients and, in animals, reduced cytogenesis was shown in healthy rats exposed to s

https://www.huntington-research.lu.se/escitalopram-reduces-increased-hippocampal-cytogenesis-genetically-depressed-rat - 2025-07-25

Bacos K, Björkqvist M, Petersén Å, Luts L, Maat-Schieman M, Roos R, Sundler F, Brundin P, Mulder H and Wierup N.Histochemistry and Cell Biology 129: 623-629 (2008)AbstractNeurodegenerative disorders are often associated with metabolic alterations. This has received little attention, but might be clinically important because it can contribute to symptoms and influence the course of the disease. Pat

https://www.huntington-research.lu.se/islet-b-cell-area-and-hormone-expression-are-unaltered-huntingtons-disease - 2025-07-25

Brundin L, Björkqvist M, Träskman-Bendz L and Petersén Å.Psychiatry Research 158(2): 117-122 (2008)AbstractCocaine and amphetamine regulated transcript (CART) is a neuropeptide expressed in brain regions thought to regulate anxiety levels, depression, addiction and energy homeostasis. Individuals with a CART mutation display increased anxiety and depression. Severe anxiety is a core phenomenon of

https://www.huntington-research.lu.se/cocaine-and-amphetamine-regulated-transcript-cart-cohort-suicide-attempters - 2025-07-25

Fjalldal S, Follin C, Gabery S, Sundgren PC, Björkman-Burtscher IM, Lätt J, Mannfolk P, Nordström CH, Rylander L, Ekman B, Cheong R, Pålsson A, Petersén Å and Erfurth EM.International Journal of Obesity (Lond). 43: 533-544 (2019) AbstractBACKGROUND/OBJECTIVES:Hypothalamic obesity (HO) occurs in 50% of patients with the pituitary tumor craniopharyngioma (CP). Attempts have been made to predict the

https://www.huntington-research.lu.se/detailed-assessment-hypothalamic-damage-craniopharyngioma-patients-obesity - 2025-07-25

Wood N, Goodman AOG, van der Burg J, Gazeau V, Brundin P, Björkqvist M, Petersén Å, Tabrizi SJ, Barker RA and Morton AJ.Brain Research Bulletin 76: 70-79 (2008)AbstractWhile Huntington's disease (HD) is a condition that primarily involves the basal ganglia, there is evidence to suggest that the hypothalamus is also affected. Because the osmoreceptors regulating thirst are situated in the circumven

https://www.huntington-research.lu.se/increased-thirst-and-drinking-huntingtons-disease-and-r62-mouse - 2025-07-25

Schultz K, Träskman-Bendz L and Petersén Å.Journal of Affective Disorders 109: 205-208 (2008)AbstractBACKGROUND: Earlier studies have found that transthyretin (TTR) is reduced in cerebrospinal fluid (CSF) from patients with major depressive disorder and that levels correlate negatively with suicidal ideation. The purpose of this study was to examine CSF-TTR in a cohort of suicide attempters with d

https://www.huntington-research.lu.se/transthyretin-cerebrospinal-fluid-suicide-attempters - 2025-07-25

Araújo IM, Gil J, Carreira BP, Mohapel P, Petersén Å, Pinheiro PS, Soulet D, Bahr BA, Brundin P and Carvalho CM.Journal of Neurochemistry 105: 666-676 (2008)AbstractEvidence for increased calpain activity has been described in the hippocampus of rodent models of temporal lobe epilepsy. However, it is not known whether calpains are involved in the cell death that accompanies seizures. In this work,

https://www.huntington-research.lu.se/calpain-activation-involved-early-caspase-independent-neurodegeneration-hippocampus-following-status - 2025-07-25

van der Burg JMM, Bacos K, Wood N, Lindqvist A, Wierup N, Wamsteeker J, Deierborg-Olsson T, Mulder H, Erlanson-Albertsson C, Morton J, Brundin P, Björkqvist M* and Petersén Å*.Neurobiology of Disease 29: 41-51 (2008) *equal contribution AbstractHuntington's disease (HD) is a hereditary disorder characterized by personality changes, chorea, dementia and weight loss. The cause of this weight loss is

https://www.huntington-research.lu.se/increased-metabolism-r62-mouse-model-huntingtons-disease - 2025-07-25

Dalrymple A, Wild E, Joubert R, Sathasivam K, Björkqvist M, Petersén Å, Isaacs J, Kristiansten M, Bates G, Leavitt B, Keir G, Ward M and Tabrizi SJ.Journal of Proteome Research 6: 2833-2840 (2007)AbstractHuntington's disease (HD) causes widespread CNS changes and systemic abnormalities including endocrine and immune dysfunction. HD biomarkers are needed to power clinical trials of potential treatm

https://www.huntington-research.lu.se/proteomic-profiling-plasma-hungtintons-disease-reveals-neuroinflammatory-acivation-and-biomarker - 2025-07-25

Brundin L, Petersén Å, Björkqvist M and Träskman-Bendz L.Journal of Affective Disorders 100: 259-263 (2007)AbstractBACKGROUND:The orexins (hypocretins) are recently discovered hypothalamic peptides that are involved in the regulation of sleep, appetite and state of arousal. In the present study, we investigated the relationship between cerebrospinal fluid (CSF) orexin and specific psychiatric symp

https://www.huntington-research.lu.se/orexin-and-psychiatric-symptoms-suicide-attempters - 2025-07-25

Björkqvist M, Leavitt B, Nielsen J, Landwehrmeyer B, Ecker D, Mulder H, Brundin P and Petersén Å.Movement Disorders 22: 1952-1954 (2007)AbstractWeight loss and anxiety frequently occur in individuals with Huntington's disease (HD) but the underlying mechanisms are not well-understood. Peptides produced in the hypothalamus are involved in regulating energy homeostasis and emotion. Recent data sugge

https://www.huntington-research.lu.se/cocaine-and-amphetamine-regulated-transcript-increased-huntington-disease - 2025-07-25