In 1974, a primary preventive project started at the Medical Clinic, Umas (now Skåne University Hospital, Malmö), under the direction of Professor Bertil Hood. Malmö Preventive Project is a cohort study that in 1974 invited all men from specific birth cohorts (1921-1949) and some years later began to invite women (born 1926-1949). The purpose was to map cardiovascular risk factors and alcohol abus

https://www.malmo-cohorts.lu.se/malmo-preventive-project-mpp - 2025-06-29

MPP is followed up annually against the National Swedish Cancer Register, the Regional Tumor Register in Lund, the Swedish Causes of Death Register, Statistics Sweden's Population Register to identify emigrants, the National Patient Register and local and national registers for stroke and heart attack. Every year we prepare endpoint reports for cancer and causes of death, cardiovascular events and

https://www.malmo-cohorts.lu.se/malmo-preventive-project-mpp/mpp-follow - 2025-06-29

Definition of the MPP cohortBerglund G, Nilsson P, Eriksson KF, Nilsson JA, Hedblad B, Kristenson H, Lindgärde F. Long-term outcome of the Malmö preventive project: mortality and cardiovascular morbidity. J Intern Med. 2000 Jan;247(1):19-29.    Link to article Nilsson PM, Nilsson JA, Berglund G. Population-attributable risk of coronary heart disease risk factors during long-term follow-up: the Mal

https://www.malmo-cohorts.lu.se/malmo-preventive-project-mpp/mpp-references - 2025-06-29

The Malmö Offspring Study is the first population study in Sweden that makes it possible to follow major endemic diseases over several generations. The focus is, but not limited to, type 2 diabetes, cardiovascular disease, dementia and cancer. Despite medical progress, everything points to the fact that endemic diseases will remain one of our greatest challenges in the future. By following trial p

https://www.malmo-cohorts.lu.se/malmo-offspring-study-mos - 2025-06-29

MKC, MFM and MOS together, form a unique material from which significant research results in cancer, heart disease and diabetes, among others, has evolved.Three cohorts with significant importance for researchMalmö Diet and Cancer, MDC, and Malmö Preventive Project, MPP, have together examined around 50,000 Malmö residents. The surveys began in the 1970s and the re-surveys were completed in 2012.

https://www.malmo-cohorts.lu.se/application-data-and-samples - 2025-06-29

Clinical Research Unit, Internal Medicine Malmö, Skåne University Hospital The Clinic Research Unit in Malmö is a core resource for patient-centred clinical research, primarily for internal medicine, but also for other departments within the hospital. The focus is on cardiovascular disease, lungs, and diabetes.Our expertise and resourcesAdvanced metabolic studiesUltrasound examinations of arteries

https://www.malmo-cohorts.lu.se/clinical-research-unit - 2025-06-29

Steering Committee - MDC/MPPProject descriptionMDC and MPP is an independent scientific project at Lund University that is jointly run by several research groups. MDC and MPP consist of databases and biobanks.A Steering Committee decides on and organizes the maintenance, expansion and extraction of data and samples. The work is coordinated by a chairman, but the project is based on joint decision-

https://www.malmo-cohorts.lu.se/management-and-contact-information - 2025-06-29

The research conducted with the help of the Malmö cohorts has generated significant results over the years. Malmö Preventive Medicine has been running since 1971, Malmö Cost Cancer since 1991 and Malmö Offspring Study since 2013. In the last 12 years, 2012-2024, approx. 1200 scientific articles have been published where data from the Malmö cohorts have been used. Here we list the scientific public

https://www.malmo-cohorts.lu.se/research-result-publications - 2025-06-29

Those who participate in the MOS study must undergo a number of examinations and make a diet registration. Information regarding this can be found in the Diet Registration Guide and the Portion Guide. Links to these can be found in the left menu. There is also a link to contact details and questions about diet registration. In the right-hand menu there is a link to a short film about how the diet

https://www.malmo-cohorts.lu.se/malmo-offspring-study-mos/participants-mos-study - 2025-06-29

Since it was started in 2013, the Malmö Offspring Study has collected large amounts of data. Here we report the scientific articles that have been published together with links to the articles. 2024Holm H, Kennbäck C, Laucyte-Cibulskiene A, Nilsson PM, Jujic A. The impact of prediabetes and diabetes on endothelial function in a large population-based cohort. Blood Press. 2024 Dec;33(1):2298309. Li

https://www.malmo-cohorts.lu.se/malmo-offspring-study-mos/references-mos - 2025-06-29

All researchers are welcome to apply for the samples of data and biological material. Our policy is that MDC/MPP should be considered an open resource. Since 2006, we have received more than 1,300 applications. Less than 25 have been rejected. Of these, several have been too broad and not specific enough, have overlapped with other projects, or touched on method development where prospectively col

https://www.malmo-cohorts.lu.se/application-data-and-samples/applying-samples-mdc-and-mpp - 2025-06-29

Initially, MDC was financed by the Cancer Foundation and MPP by the healthcare system in Malmö. Until 2005, we were able to provide samples and data extractions free of charge. Today, however, our operations must be revenue-financed.Our biggest expense is personnel costs. We have a full-time data manager and a full-time project coordinator. In case of large extractions, we also have to take help f

https://www.malmo-cohorts.lu.se/application-data-and-samples/costs-extractions-samples-and-data-mdc-and-mpp - 2025-06-29

Three major cohorts in the Malmö Cohorts The Malmö Diet and Cancer CohortThe Malmö Preventive ProjectThe Malmö Offspring StudyMalmö Diet and Cancer, MDC, and Malmö Preventive Project, MPP, have together examined 50 000 Malmö residents. The examinations began in the 1970s and the re-examinations were completed in 2021. The Malmö Offspring Study started in 2013 and examines the children and grandchi

https://www.malmo-cohorts.lu.se/malmo-cohorts - 2025-06-29

Current positionGuest researcher, Biotech Research & Innovation Centre (BRIC), University of CopenhagenKate [dot] Herum [at] bric [dot] ku [dot] dkThesis titleSyndecan-4 in cardia fibroblasts - Role in regulation of extracellular matrix and myocardial stiffnessLists of papers included1) K.M. Herum, I.G. Lunde, B. Skrbic, G. Florholmen, D. Behmen, I. Sjaastad, C.R. Carlson, M.F. Gomez & G. Christen

https://www.ludc.lu.se/research-0/diabetic-complications/lab-alumni/kate-louise-moller-herum - 2025-06-29

We shall explore genetic function by a combination of genetic and functional assays. First, via expression profiling, we intend to determine which genes for mitochondrial proteins are altered in pancreatic β-cells, liver, skeletal muscle, and adipose tissue. This will be performed in material from i) humans with or without the disease, ii) in genetically or pharmacologically manipulated animals an

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/mitocondria - 2025-06-29

To accomplish these goals we will: A) establish the stimulus-secretion coupling in human pancreatic islets from non-diabetic organ donors to obtain proof of concepts derived from rodent studies; these data will also establish the gold standard for efforts to differentiate embryonic stem cells into mature islet cells. B) Combine islet studies with genetic and metabolic studies in humanA) Our knowle

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/islets - 2025-06-29

How do we get people from different cultures, industries and worlds to sit down and talk to each other? First, they need to be brought together, and this alone requires the right person for the job. Meet Paola Hjelt, member of Lund University Diabetes Centre’s Innovation Board, who talks about on how to accomplish a change of mindset. She grew up in Brussels, Belgium, has one degree from the Stock

https://www.ludc.lu.se/meetings-prerequisite-change - 2025-06-29

PI: Nils Wierup The emergence of morbidly obese patients has prompted novel approaches to achieve weight reduction. Given that energy reduction by dieting is largely unsuccessful in this paitent group, surgical procedures have instead been developed to dramatically restrict food intake. Indeed, over the course of months patients may loose up to 50% in body weight. In addition, the majority of pati

https://www.ludc.lu.se/about-us/action-groups/metabolic-surgery-action-group - 2025-06-29

PI: Albert Salehi The antiology of metabolic syndrome and type 2 diabetes is complex and involves the interaction between both genetic and environmental factors (also including nutritional and metabolic signals). It has been known for at long time that dysfunction fo pancreatic islets cell (α-, β- and δ-cell) is a critical factor in the development and progression of these diseases.One of the larg

https://www.ludc.lu.se/about-us/action-groups/gpcr-action-group - 2025-06-29

Glucolipotoxicity:We will identify defects in the regulation of adipose tissue lipid metabolism associated with obesity and diabetes using models with altered expression of hormone sensitive lipase (HSL), the rate-limiting step in lipolysis 39 and phosphodiesterase3B (PDE3B) 40-42, a key enzyme controlling insulin action HSL activity. Altered profiles of lipid derived second messengers and alterat

https://www.ludc.lu.se/welcome-lund-university-diabetes-centre/project-areas/target-tissues - 2025-06-29