BACKGROUND: Excessive daytime sleepiness (EDS), experienced in 10% to 20% of the population, has been associated with cardiovascular disease and death. However, the condition is heterogeneous and is prevalent in individuals having short and long sleep duration. We sought to clarify the relationship between sleep duration subtypes of EDS with cardiovascular outcomes, accounting for these subtypes.

In nanoscale systems coupled to finite-size reservoirs, the reservoir temperature may fluctuate due to heat exchange between the system and the reservoirs. To date, a stochastic thermodynamic analysis of heat, work, and entropy production in such systems is, however, missing. Here we fill this gap by analyzing a single-level quantum dot tunnel coupled to a finite-size electronic reservoir. The sys

This paper serves as a detailed research proposal for a newly started PhD-project concerning multimetal craftsmanship in the Scandinavian later Iron Age. The project employs landscape survey, material and archaeometallurgical analysis of metallurgical debris, and a theoretical framework grounded in economic theory to counter fundamental key questions surrounding metalworking, metalworkers, and the

Background: About one in ten adults are living with diabetes worldwide. Intake of carbohydrates and carbohydrate-rich foods are often identified as modifiable risk factors for incident type 2 diabetes. However, strong correlation between food variables can make it difficult to identify true associations. The purpose of this study was to identify clusters of carbohydrate-rich foods and analyse thei

The bark beetle, Ips typographus (L.), is a major pest of Norway spruce, Picea abies (L.), causing enormous economic losses globally. The adult stage of the I. typographus has a complex life cycle (callow and sclerotized); the callow beetles feed ferociously, whereas sclerotized male beetles are more aggressive and pioneers in establishing new colonies. We conducted a comparative proteomics study

Breast cancer is now the most frequently diagnosed cancer in the world. Breast cancer prevention has gained increasing attention due to increasing breast cancer incidence rates in the West and can be actualized through lifestyle modifications or targeted interventions. Mammographic breast density (MBD) is a well-established independent breast cancer risk factor that is not well-understood on a mol

Research has supported the use of preperformance routines to successfully manage the period preceding sport performance. In contrast, little research has been done on the period succeeding skill execution. This article introduces a three-stage model for postperformance routines (PoPR) for novice motor learning and performance including emotion regulation, performance analysis and correction, and c

We demonstrate, using analytic models, simulations and experiments, that efficient generation of high-order harmonics is possible across a large range of parameters, if the density and medium length follow a hyperbolic equation.

This paper presents an injection-locked frequency tripler for 28-GHz direct-conversion transceivers, which takes a differential input and outputs a quadrature signal. A feedback system is added to ensure that lock occurs and to keep the quadrature error below 1° across operating frequencies and process corners. Simulations show that the tripler can cover the entire 24-30 GHz band across all corner

Flatness of the loss curve around a model at hand has been shown to empirically correlate with its generalization ability. Optimizing for flatness has been proposed as early as 1994 by Hochreiter and Schmidthuber, and was followed by more recent successful sharpness-aware optimization techniques. Their widespread adoption in practice, though, is dubious because of the lack of theoretically grounde

Introduction: The European corn borer (ECB), Ostrinia nubilalis (Hübner) (Lepidoptera: Crambidae), is a major pest insect in maize. New cultivars and climate change have allowed range expansion of the crop northwards in Europe, and a similar range expansion of associated pests has been predicted. ECB exists as two distinct pheromone strains using different blends of (E)-11-tetradecenyl acetate and

Fibromyalgia is a common chronic pain condition. Rates of contact allergy in individuals with fibromyalgia have not been widely studied. Systemic contact allergy can present with muscle and joint pain and general malaise. The aim of this study is to investigate contact allergy rates in individuals with fibromyalgia to the sensitizers in an extended dental series and compare with control groups. Co

In the fields of behavioural and psychological research, pupil size and skin conductance are two variables that provide useful information about a participant’s state of mind at a given moment. Both variables are involuntary indicators of psychophysiological responses such as alertness, arousal, or focus. Pupil size is commonly measured with a video-based eye tracker, and skin conductance is measu

Background: Tonsillar cancer is caused by high-risk human papillomavirus (HPV), tobacco smoking, and alcohol abuse. Aspects of the patient’s immune response to this disease have arisen as prognostic factors and treatment targets, reflecting differences in the type and protein expression profile of immune cells. Because tonsillar cancers are heterogenous lesions such data need to be spatially resol

The European Spallation Source (ESS) is an under-construction material science research facility in Lund, Sweden, and will upon completion host the most powerful superconducting linear accelerator (linac) in the world. The ESS linac is powered by klystron modulators required to deliver long high-power pulses (pulse amplitude 115 kV/100 A, pulse length 3.5 ms, pulse repetition rate 14 Hz) of very h

This article discusses the rationale for inclusion of flow cytometry (FCM) in the diagnostic investigation and evaluation of cytopenias of uncertain origin and suspected myelodysplastic syndromes (MDS) by the European LeukemiaNet international MDS Flow Working Group (ELN iMDS Flow WG). The WHO 2016 classification recognizes that FCM contributes to the diagnosis of MDS and may be useful for prognos

Radionuclide therapy, also called molecular radiotherapy (MRT), has come of age, with several novel radiopharmaceuticals being approved for clinical use or under development in the last decade. External beam radiotherapy (EBRT) is a well-established treatment modality, with about half of all oncologic patients expected to receive at least one external radiation treatment over their disease course.