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(Un)becoming dysfunctional: ADHD and how matter comes to matter

Various neuropsychiatric disorders are a common feature today, not leastin educational contexts where Attention Deficit Hyper Activity Disorder(ADHD) is a common diagnosis. The dominant perspective regardingADHD is biomedical. This perspective has been questioned andchallenged in various ways. The aim of this article is to think ADHDthrough quantum physicist and philosopher Karen Barad’s [Barad, KVarious neuropsychiatric disorders are a common feature today, not leastin educational contexts where Attention Deficit Hyper Activity Disorder(ADHD) is a common diagnosis. The dominant perspective regardingADHD is biomedical. This perspective has been questioned andchallenged in various ways. The aim of this article is to think ADHDthrough quantum physicist and philosopher Karen Barad’s [Barad, K

The presence of a short redox chain in the membrane of intact potato tuber peroxisomes and the association of malate dehydrogenase with the peroxisomal membrane

Peroxisomes and mitochondria were purified from potato tubers (Solanum tuberosum L. cv. Bintje) by differential centrifugation followed by separation on a continuous Percoll gradient containing 0.3 M sucrose in the lower half and 0.3 M mannitol in the upper half. The peroxisomes band at the bottom and the mitochondria in the middle of this type of gradient. Mitochondrial contamination of the perox

Assessing risk for preclinical β-amyloid pathology with APOE, cognitive, and demographic information

Introduction Clinical trials in Alzheimer's disease are aimed at early stages of disease, including preclinical Alzheimer's disease. The high cost and time required to screen large numbers of participants for Aβ pathology impede the development of novel drugs. This study's objective was to evaluate the extent to which inexpensive and easily obtainable information can reduce the number of screen fa

Perceived social status among people with psychiatric disabilities attending work-oriented and meeting place-oriented day centers

BACKGROUND: Day centers have been criticized for giving attendees a lower social status because they only offer activities that are often work-like although not financially of benefit to attendees. OBJECTIVES: To explore day center attendees' perceived social status and to identify associations among the attendees with the center's orientation with activity, well-being, and psychiatric symptoms. M

Gonadotropin-releasing hormone agonist against severe aggression in autism

Aggression in patients with autism spectrum disorder (ASD) presents an important therapeutic challenge. Conventional treatment appears to be inadequate in a number of cases. The occurrence of severe aggressive symptoms since the inception of adolescence in a male patient with ASD suggested a hormonal influence by androgens. Conventional treatment with antipsychotic and antiepileptic drugs and benz

Visual grading evaluation of commercially available metal artefact reduction techniques in hip prosthesis computed tomography

Objective: To evaluate metal artefact reduction (MAR) techniques from four CT vendors in hip prosthesis imaging. Methods: Bilateral hip prosthesis phantom images, obtained by using MAR algorithms for single-energy CT data or dual-energy CT (DECT) data and by monoenergetic reconstructions of DECT data, were visually graded by five radiologists using 10 image quality criteria. Comparisons between th

The "Free from housing accessibility problems" app

The present study concerns the development of a computerized tool targeting housing accessibility issues. A user-centered approach involving professionals from the housing sector and senior citizens from four European countries resulted in a fully functional prototype of a mobile application (app) including an apartment database. The app raises awareness on housing accessibility and has the potent

Inflamed in vitro retina : Cytotoxic neuroinflammation and galectin-3 expression

Background Disease progression in retinal neurodegeneration is strongly correlated to immune cell activation, which may have either a neuroprotective or neurotoxic effect. Increased knowledge about the immune response profile and retinal neurodegeneration may lead to candidate targets for treatments. Therefore, we have used the explanted retina as a model to explore the immune response and express

Acetic acid as a decontamination method for sink drains in a nosocomial outbreak of metallo-β-lactamase-producing Pseudomonas aeruginosa

Background Pseudomonas aeruginosa may colonize water systems via biofilm formation. In hospital environments, contaminated sinks have been associated with nosocomial transmission. Here we describe a prolonged outbreak of a metallo-β-lactamase-producing P. aeruginosa (Pae-MBL) associated with sink drains, and propose a previously unreported decontamination method with acetic acid. Aim To describe a

Transmitter-specific subsets of sensory elements in the prosobranch osphradium.

The osphradium is a putative chemosensory organ of aquatic molluscs. Previously, we identified two distinct types of primary sensory neurons in the osphradial ganglion of freshwater pulmonates, one immunoreactive to leucine-enkephalin (LEnk-ir) and another to FMRFamide (FMRFa-ir). In addition, NADPH diaphorase (NADPHd)-positive elements apparently producing nitric oxide (NO) were demonstrated in t

Sensory structures associated with the cuticle of Hutchinsoniella macracantha (Crustacea, Cephalocarida)

The body cuticle of the cephalocarid crustacean Hutchinsoniella macracantha Sanders, 1955, carries two types of small setae which differ in their external shape and number of ciliated sensory cells. It also has two types of pores, one being a gland opening, the other containing the tip of a cilium. The setae and the pore type containing a ciliated sensory cell are considered chemosensory organs.

Serotonin- and FMRFamide-immunoreactive nerve elements in the chiton, Lepidopleurus asellus (Mollusca, Polyplacophora)

The distribution of serotonin-like and FMRFamide-like immunoreactive (5HT-ir and FMRFa-ir, respectively) neurons in the nervous system of the chiton Lepidopleurus asellus (Mollusca, Polyplacophora) was studied using an immunocytochemical technique. The neurons were distributed in characteristic patterns in the central nervous system, the 5HT-ir neurons predominating in the ventral (pedal) cords an

Immunolabeled neuroactive substances in the osphradium of the pond snail, Lymnea stagnalis.

The osphradium of molluscs is assumed to be a sensory organ. The present investigation in Lymnaea stagnalis has established two ultrastructurally different types of dendrites in the sensory epithelium. Cells immunoreactive to leucine-enkephalin and FMRFamide send processes to the sensory epithelium. These neurons of the osphradial ganglion are thus considered to be part of the sensory system, as a

Patterns of enkephalin immunolabeling in the pulmonate snail Cepea nemoralis and related molluscs.

In the land pulmonate snailCepaea nemoralis, immunocytochemical localization of methionine- and leucine-enkephalin-like substances was demonstrated in specific populations of brain neurons. Methionine-enkephalin reactivity is also present in the peripheral nervous system as (i) abundant axonal projections of central neurons to the sole of the foot, and (ii) sparse local neurons of the head and man

Is nitric oxide (NO) produced by invertebrate neurons?

NADPH-DIAPHORASE (NADPHd) is known to be identical to nitric oxide (NO) synthase in the mammalian nervous system, and is therefore used as a marker of NO-producing neurones. Using the histochemical reaction for NADPHd, we searched for such neurones in a selection of invertebrates. Special emphasis was given to molluscs. No selective neuronal staining was found in representatives of coelenterates,