As the use of engineered nanomaterials increases, so does the risk of them spreading to natural ecosystems. Hitherto, knowledge regarding the toxic properties of nanoparticles (NP’s) and their potential interactions with natural bio-organic molecules adsorbed to them, and thereby forming surface coronas, is limited. However, we show here that the toxic effect of NPs of tungsten carbide cobalt (WC–

HIP 41378 d is a long-period planet that has only been observed to transit twice, three years apart, with K2. According to stability considerations and a partial detection of the Rossiter- McLaughlin effect, Pd = 278.36 d has been determined to be the most likely orbital period. We targeted HIP 41378 d with CHEOPS at the predicted transit timing based on Pd = 278.36 d, but the observations show no

A producer-independent, problem-oriented, group-education programme with 2-day meetings on drug treatment in primary health care (PHC) was developed and evaluated. Initially, it was tested on a selected group of general practitioners (district physicians), using a non-exposed group as control. A comprehensive questionnaire was used to test changes in attitudes. There was a significant change in at

Nutrient availability is of major importance for plant productivity. When estimating long-term sustainability from a nutrient perspective it is therefore interesting to focus on long-term changes in the soil nutrient pools when comparing different forest types. Here, we have highlighted some factors of importance for long term nutrient sustainability (e.g., several forest rotations) and pointed ou

The reserves, production from mines, supply of aluminium to society and mass fluxes of aluminium in society was assessed using an integrated systems dynamics model (ALUMINIUM) in order to reconstruct the past and investigate potential future scenarios. The investigations for input data show that the mine- able aluminium reserves are large, but finite. We get an average value for the ultimately rec

Antiarrhythmic effects of melatonin have been demonstrated ex vivo and in rodent models, but its action in a clinically relevant large mammalian model remains largely unknown. Objectives of the present study were to evaluate electrophysiological and antiarrhythmic effects of melatonin in a porcine model of acute myocardial infarction. Myocardial ischemia was induced by 40-min coronary occlusion in

Water scarcity is one of the major challenges in semi-arid and arid areas. Drivers for water scarcity include climate change, population growth, economic, and agricultural development. This paper presents a framework for assessing water scarcity under the impact of climate, industry, and socio-economic changes in the Qazvin Plain, Iran. A system dynamics model is developed and calibrated using his

Estimations show that approximately US $23 billion is required for Georgia to meet its climate and environmental targets up to 2030. As the current Nationally Determined Contribution reveals, considering 1990 as a base year, the Republic of Georgia plans a 35% decrease in greenhouse gas emissions by 2030. If the country has financial and technical support, commitment to limit emissions may rise as

The effects of the polyamines putrescine, spermidine and spermine on the mechanical activity in smooth muscle from guinea-pig taenia coli were investigated. Tissue concentrations of spermidine and spermine were about 240 and 160 nmol g-1, respectively, while the putrescine concentration was much lower (4 nmol g-1). Intracellular [Ca2+] was determined using the Fura-2 method and the effects of extr

Background and purpose — Surveillance of scoliosis in individuals with cerebral palsy (CP) is important for ensuring timely diagnosis and identification of curve progression. We analyzed the incidence of scoliosis in relation to age, sex, and gross motor function in a population-based cohort of individuals with CP. Patients and methods — This was a prospective register study of all 1,025 individua

The single amino acid mutation G26R in human apolipoprotein A-I (apoA-IIOWA) leads to the formation of beta-secondary structure rich amyloid fibrils in vivo. Here we show that full-length apoA-IIOWA has a decreased lipid-binding capability, an increased amino-terminal sensitivity to protease, and a propensity to form annular protofibrils visible by electron microscopy. The molecular basis for the

Aging buildings will sooner or later be in need of renovation, which opens opportunities to reduce energy use. Even if economically feasible energy measures or technologies exist, they are not always implemented, leading to an energy efficiency gap. This dissertation deals with how energy measures are handled and why they are enabled or disabled during the planning and design of renovations. Durin

This thesis is a qualitative case study of Venezuelan migrants living in Buenos Aires, Argentina. This study examines how migrants experience the four main barriers to socio economic integration – labour market exclusion, housing insecurity, institutional hurdles and everyday discrimination as well as the implications of these barriers. The theoretical framework of this thesis combines intersectio

Erasmus+ is a European Union (EU) grant programme aimed at education, youth and sport. The programme funds projects for 5€ billion per year, impacting around 84 000 organisations. Erasmus+ is an example of how the EU implements sustainability policy through soft governance tools. Through an analysis of sustainability criteria in Erasmus+, this thesis explores how EU policy in grant programmes impa