Karlsson J, Petersén Å, Gidö G, Wieloch T and Brundin P.Cell Transplantation 14: 301-309 (2005)AbstractAround 80-95% of the immature dopaminergic neurons die when embryonic ventral mesencephalic tissue is transplanted. Cell death occurs both during the preparation of donor tissue and after graft implantation, but the effect of combining successful neuroprotective treatments before and after transp

https://www.huntington-research.lu.se/combining-neuroprotective-treatment-embryonic-nigral-donor-tissue-mild-hypothermia-graft-recipient - 2025-04-29

Araujo IM, Xapelli S, Gil JM, Mohapel P, Petersén Å, Pinheiro PS, Malva JO, Bahr BA, Brundin P and Carvalho CM.Neuroreport 16: 393-396 (2005)AbstractOveractivation of N-methyl-D-aspartate receptors is known to mediate excitotoxicity due to excessive entry of calcium, leading to the activation of several calcium-dependent enzymes. Calpains are calcium-activated proteases that appear to play a role

https://www.huntington-research.lu.se/proteolysis-nr2b-calpain-hippocampus-epileptic-rats - 2025-04-29

Papalexi E, Persson A, Björkqvist M, Petersén Å, Woodman B, Bates GP, Sundler F, Mulder H, Brundin P and Popovic N.European Journal of Neuroscience 22: 1541-1546 (2005)AbstractReductions in testosterone and luteinizing hormone levels and reduced sexual functions have been reported in Huntington's disease (HD) patients. Atrophy of the reproductive organs and loss of fertility have also been observe

https://www.huntington-research.lu.se/reduction-gnrh-and-infertility-r62-mouse-model-huntingtons-disease - 2025-04-29

Gil MAC J, Leist M, Popovic N, Brundin P and Petersén Å.BMC Neuroscience 5: 17 (2004)AbstractBACKGROUND:Huntington's disease (HD) is a hereditary neurodegenerative disorder caused by an expanded CAG repeat in the HD gene. Both excitotoxicity and oxidative stress have been proposed to play important roles in the pathogenesis of HD. Since no effective treatment is available, this study was designed

https://www.huntington-research.lu.se/asialoerythropoetin-not-effective-r62-line-huntingtons-disease-mice - 2025-04-29

Petersén Å, Puschban Z, Lotharius J, NicNiocaill B, Wiekop B, O´Connor, WT and Brundin P.Neurobiology of Disease 11: 134-146 (2002)AbstractThe present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxy

https://www.huntington-research.lu.se/evidence-dysfunction-nigrostriatal-pathway-r61-line-transgenic-huntingtons-disease-mice - 2025-04-29

Petersén Å, Chase K, Puschban Z, DiFiglia M, Brundin P and Aronin N.Experimental Neurology 175: 297-300 (2002)AbstractA transgenic mouse model of Huntington's disease (R6/1 and R6/2 lines) expressing exon 1 of the HD gene with 115-150 CAG repeats resisted striatal damage following injection of quinolinic acid and other neurotoxins. We examined whether excitotoxin resistance characterizes mice with

https://www.huntington-research.lu.se/maintenance-susceptibility-neurodegeneration-following-intrastriatal-injections-quinolinic-acid-new - 2025-04-29

Petersén Å and Brundin P.International Review of Neurobiology 53: 315-339 (2002) SummaryThe Huntington's disease (HD) has stimulated novel clinical drug trials based on the ideas about mechanisms of cell death in the disorder. A recent study investigated the effects of remacemide and coenzyme Q on progression of symptoms in HD. These drugs are an N-methyl-d-aspartate (NMDA) antagonist and a mitoch

https://www.huntington-research.lu.se/huntingtons-disease-mystery-unfolds - 2025-04-29

Petersén Å, Hansson O, Puschban Z, Sapp E, Romero N, Castilho RF, Sulzer D, Rice M, DiFiglia M, Przedborski S and Brundin P.European Journal of Neuroscience 14: 1-13 (2001)AbstractHuntington's disease is an autosomal dominant hereditary neurodegenerative disorder characterized by severe striatal cell loss. Dopamine (DA) has been suggested to play a role in the pathogenesis of the disease. We have

https://www.huntington-research.lu.se/mice-transgenic-exon-1-huntingtons-disease-gene-display-reduced-striatal-sensitivity-neurotoxicity - 2025-04-29

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P and Sulzer D.Human Molecular Genetics 10: 1243-1254 (2001)AbstractHuntington's disease (HD) is caused by an expanded CAG repeat in exon 1 of the gene coding for the huntingtin protein. The cellular pathway by which this mutation induces HD remains unknown, although alterations in protein degradation are involved. To study intrinsic

https://www.huntington-research.lu.se/expanded-cag-repeats-exon-1-huntingtons-disease-gene-stimulate-dopamine-mediated-striatal-neuron - 2025-04-29

Petersén Å, Larsen KE, Behr GG, Romero N, Przedborski S, Brundin P, and Sulzer D.Section for Neuronal Survival, Wallenberg Neuroscience Center, Lund University, Lund, SwedenBrain Research Bulletin 56(3-4): 331-335 (2001)AbstractIn hereditary Huntington's disease, a triplet repeat disease, there is extensive loss of striatal neurons. It has been shown that brain-derived neurotrophic factor (BDNF) p

https://www.huntington-research.lu.se/brain-derived-neurotrophic-factor-inhibits-apoptosis-and-dopamine-induced-free-radical-production - 2025-04-29

REGISTER, PUBLISH AND MAKE YOUR DISSERTATION VISIBLE Here you find compiled information for doctoral students at Lund University about the procedure for registering, publishing and making their doctoral theses visible. Theses written at Lund University require ISBN number. Depending on which faculty and institution you belong to, you may order ISBN either from your faculty or from the University L

https://www.ub.lu.se/en/publish/doctoral-theses - 2025-04-29

Registration in LUCRIS and adding a full text As a doctoral student at LU, you use LUCRIS to register your degree project and the thesis. The registration makes the thesis visible in LU's Research Portal and on the university's calendar for upcoming defenses. Also, make the theses freely available whenever possible. Register your doctoral thesis As a doctoral student at LU, you use LUCRIS to regis

https://www.ub.lu.se/en/publish/doctoral-theses/register-and-publish-thesis - 2025-04-29

Lund University has been a member of The SND Consortium, Swedish National Data Service, since 2018. The consortium includes seven universities and also has a network of twenty more additional universities. The consortium aims to build services for the description and publication of research data, based on, among other things, SND's existing supply and experience from almost 40 years of work in soc

https://www.ub.lu.se/en/publish/research-data/consortium-snd-swedish-national-data-service - 2025-04-29

Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreementThe agreement provides open access publishing under negotiated terms in 25 hybrid journals from AIP Publishing. Publishing in fully open-access journals is not included in the agreement.

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/aip-publishing - 2025-04-29

Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreement Authors affiliated to Lund University can publish open access in the publisher's journals. The agreement applies to all of Cogitatio’s journals. Initially the cost of publishing is paid

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/cogitatio-press - 2025-04-29

This applies to doctoral students at Lund University only. Before you send your doctoral thesis to print it will need a unique ID. This is called International Standard Book Number (ISBN), and is usually printed on the first page of the doctoral thesis. Depending on which faculty and institution you belong to, you may order an ISBN either from your faculty or from the university library.The Univer

https://www.ub.lu.se/en/publish/doctoral-theses/isbn-doctoral-thesis - 2025-04-29

Read- and publish agreement Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreementThe agreement provides open access publishing under negotiated conditions in most journals from Oxford University Press. Both open access journals and hybrid

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/OUP - 2025-04-29

Read- and publish agreement Researchers at Lund University can use agreements to publish open access with easy handling of the administrative processes and negotiated costs. Read more about the terms of the agreement here. About the agreementThe agreement provides open access publishing under negotiated conditions in approximately 400 journals from Cambridge University Press. Both open access jour

https://www.ub.lu.se/en/publish/open-access/publishing-agreements-and-discounts/cambridge-university-press - 2025-04-29

Lund University’s research output, for example articles, doctoral theses, conference papers, and reports, are collected in the LUCRIS research information system. In many cases, researchers can make their work freely accessible in full text. Reviewed and validated research output is public and visible in Lund University research portal. Registering and uploading your publication in LUCRIS Use your

https://www.ub.lu.se/en/publish/lucris-and-lu-research-portal - 2025-04-29

Patterns of collaboration and use of contemporary large neutrons and x-rays research infrastructures Sweden is investing billions of Euros in the neutron facility ESS and the synchrotron facility MAX IV, both in Lund, and the experimental resources these facilities make available will most likely alter the dynamics of Swedish science dramatically. How is contemporary science organized? What is the

https://www.ub.lu.se/en/small-science-big-machines - 2025-04-29