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On the behavior of prolate spheroids in a standing surface acoustic wave field

The active manipulation of particle and cell trajectories in fluids by high-frequency standing surface acoustic waves (sSAW) allows to separate particles and cells systematically depending on their size and acoustic contrast. However, process technologies and biomedical applications usually operate with non-spherical particles, for which the prediction of acoustic forces is highly challenging and

Inter-Organizational Home Care Nursing Teams : A Comparison of a Region Wide Organizational Change Initiative With Success Factors Identified by Forerunners and Team Theory

Teamwork is considered something positive. While there is much research on teamwork in healthcare, research on teamwork in home care nursing is limited. As the need for home care nursing is likely to increase in the future, it is of great interest to investigate the circumstances associated with the implementation of teamwork in home care nursing. The present study compares the results from a larg

The α-synuclein PET tracer [18F] ACI-12589 distinguishes multiple system atrophy from other neurodegenerative diseases

A positron emission tomography (PET) tracer detecting α-synuclein pathology will improve the diagnosis, and ultimately the treatment of α-synuclein-related diseases. Here we show that the PET ligand, [18F]ACI-12589, displays good in vitro affinity and specificity for pathological α-synuclein in tissues from patients with different α-synuclein-related disorders including Parkinson’s disease (PD) an

Design, structure and plasma binding of ancestral β-CoV scaffold antigens

We report the application of ancestral sequence reconstruction on coronavirus spike protein, resulting in stable and highly soluble ancestral scaffold antigens (AnSAs). The AnSAs interact with plasma of patients recovered from COVID-19 but do not bind to the human angiotensin-converting enzyme 2 (ACE2) receptor. Cryo-EM analysis of the AnSAs yield high resolution structures (2.6–2.8 Å) indicating

Development of an analytical exponential-6 equation of state through Monte Carlo simulations

The exponential-6 (exp-6) potential is commonly used to model fluids at high densities. In this paper, I propose a new equation of state (EOS) in the form of an analytical expression for the excess Helmholtz free energy of an exp-6 fluid. The EOS is based on extensive Monte Carlo simulations and therefore combines the excellent accuracy of the simulations with the numerical efficiency of a polynom

i ett hus vid skogens slut

Manus till teaterföreställningen i ett hus vid skogens slut som gjordes på Turteatern i Stockholm."Vid civilisationens ände tittar människan yrvaket upp. En ångest som liknar en tomhet dånar i hennes inre. Strategierna för distraktion fungerar inte längre. Information flödar in i henne utan att hitta fästpunkter, politiken är lika död som de för länge sedan bortglömda gudarna, och själva pengasyst

Outcomes and Implications of Nasal Measurements in Obstructive Sleep Apnea

BackgroundObstructive sleep apnea (OSA) is a prevalent disorder and symptoms of nasal obstruction are highly prevalent in OSA. Treatment of nasal obstruction in OSA patients has shown modest and variable outcomes in reducing the apnea hypopnea index (AHI), but significant improvements in other indicators, such as sleep quality and daytime sleepiness as well as reductions in arousals have been obse

Sublimation of refractory minerals in the gas envelopes of accreting rocky planets

Protoplanets growing within the protoplanetary disk by pebble accretion acquire hydrostatic gas envelopes. Due to accretion heating, the temperature in these envelopes can become high enough to sublimate refractory minerals which are the major components of the accreted pebbles. Here we study the sublimation of different mineral species and determine whether sublimation plays a role during the gro

Investigating the amplitude and rotation of the phase spiral in the Milky Way outer disc

Context. With data releases from the astrometric space mission Gaia, exploration of the structure of the Milky Way is now possible in unprecedented detail, and has unveiled many previously unknown structures in the Galactic disc and halo. One such feature is the Gaia phase spiral where the stars in the Galactic disc form a spiral density pattern in the Z- VZ plane. Many questions regarding the pha

Isotope effects in dynamics of water isotopologues induced by core ionization at an x-ray free-electron laser

Dynamical response of water exposed to x-rays is of utmost importance in a wealth of science areas. We exposed isolated water isotopologues to short x-ray pulses from a free-electron laser and detected momenta of all produced ions in coincidence. By combining experimental results and theoretical modeling, we identify significant structural dynamics with characteristic isotope effects in H2O2+, D2O

Equilibrium melting probabilities of a DNA molecule with a defect : An exact solution of the Poland-Scheraga model

In this study we derive analytically the equilibrium melting probabilities for basepairs of a DNA molecule with a defect site. We assume that the defect is characterized by a change in the Watson-Crick basepair energy of the defect basepair, and in the associated two stacking energies for the defect, as compared to the remaining parts of the DNA. The defect site could, for instance, occur due to D

Electron population dynamics in resonant non-linear x-ray absorption in nickel at a free-electron laser

Free-electron lasers provide bright, ultrashort, and monochromatic x-ray pulses, enabling novel spectroscopic measurements not only with femtosecond temporal resolution: The high fluence of their x-ray pulses can also easily enter the regime of the non-linear x-ray-matter interaction. Entering this regime necessitates a rigorous analysis and reliable prediction of the relevant non-linear processes

Measuring the physical imprints of gas flows in galaxies : I. Accretion rate histories

Context. Galaxies are expected to accrete pristine gas from their surroundings to sustain their star formation over cosmic timescales. This mechanism is well established in models and simulations, but evidence from observations is mostly indirect. These gas inflows leave distinct traces in the chemical composition of newborn stars and alter the distribution of stellar abundances compared to what w

Planet formation throughout the Milky Way : Planet populations in the context of Galactic chemical evolution

As stellar compositions evolve over time in the Milky Way, so will the resulting planet populations. In order to place planet formation in the context of Galactic chemical evolution, we made use of a large (N = 5325) stellar sample representing the thin and thick discs, defined chemically, and the halo, and we simulated planet formation by pebble accretion around these stars. We built a chemical m

Control of spin polarization through recollisions

Using only linearly polarized light, we study the possibility of generating spin-polarized photoelectrons from xenon atoms. No net spin polarization is possible, since the xenon ground state is spinless, but when the photoelectrons are measured in coincidence with the residual ion, spin polarization emerges. Furthermore, we show that ultrafast dynamics of the recolliding photoelectrons contribute