Free energy calculations play a crucial role in simulating chemical processes, enzymatic reactions, and drug design. However, assessing the reliability and convergence of these calculations remains a challenge. This study focuses on single-step free-energy calculations using thermodynamic perturbation. It explores how the sample distributions influence the estimated results and evaluates the relia

Horismenus Walker (Hymenoptera: Eulophidae) is one of the largest genera in Eulophidae, and additional collecting in tropical America will undoubtedly add numerous new species. Here we describe nine new species of Horismenus from material collected in Brazil, mainly in Atlantic Forest remnants: H. amplicavus sp. nov., H. atlanticus sp. nov., H. bilineatus sp. nov., H. crastoensis sp. nov., H. nova

Background: The T-peak-to-T-end ($\mathrm{T}_{pe}$) interval has shown potential in predicting ventricular arrhythmic risk. It is an appealing index to be measured during ischemia since it is less influenced by ST-segment changes than the early part of the T wave. A time-warping-based index, derived from a spatially transformed PCA lead, $d^{{\kern0.28436pt}\text{PCA}}_{w,{\scriptscriptstyle \math

Objectives: This study aims to determine the independent impact of definitions of remission/low disease activity (LDA) on direct/indirect costs (DCs, ICs) in a multicentre inception cohort. Methods: Patients from 31 centres in 10 countries were enrolled within 15 months of diagnosis and assessed annually. Five mutually exclusive disease activity states (DAS) were defined as (1) remission off-treat

The Scania and Blekinge Court of Appeal in southern Sweden was established by King Charles XIV John in 1821. The iconography used during its period in Kristianstad, until it moved to Malmö in 1917, provides an excellent example of ‘power in images’, highlighting the transition from neoclassicism to national romanticism and finally modernity.In the text, I discuss the choices of symbols that were m

Lund University (Sweden) teacher education students' reflections constitute the foundation for this chapter. The students wrote about their situation, what they could learn from it and how they could bring these lessons into their future roles. The students' voices on digitalisation and isolation in their learning experiences illustrate the importance of belonging and motivation in education. The

We present here the genomic structures for two genes implicated in craniofacial development. Retinoic acid receptor alpha (RARA), or a gene in its vicinity, has been implicated in non-syndromic cleft lip and palate, based on both association and linkage studies. Using primers directed to the 3' -UTR of the published cDNA sequence, we screened a human genomic BAC library to obtain a clone containin

BACKGROUND: Respiratory syncytial virus (RSV) and influenza cause significant health challenges, particularly for individuals with comorbid conditions and older adults. However, information on the clinical manifestations and outcomes of adults hospitalized with RSV in Europe remains limited.METHODS: This multicenter observational cohort study of adults hospitalized with RSV or influenza A or B fro

Complex metabolic diseases due to overnutrition such as obesity, type 2 diabetes, and fatty liver disease are a major burden on the healthcare system worldwide. Current research primarily focuses on disease endpoints and trying to understand underlying mechanisms at relatively late stages of the diseases, when irreversible damage is already done. However, complex interactions between physiological

BACKGROUND: Self-reported mental stress is not consistently recognized as a risk factor for stroke. This prompted development of a novel algorithm for stress-phenotype indices to quantify chronic stress prevalence in relation to a modified stroke risk score in a South African cohort. The algorithm is based on biomarkers adrenocorticotrophic hormone, high-density lipoprotein cholesterol, high-sensi

While hybridisation in vascular plants has received considerable attention, hybridisation in bryophytes is still relatively understudied. Here we investigate hybridisation between two species from the moss genus Dicranum Hedw. Dicranum scoparium Hedw. and D. bonjeanii De Not. are two moss species of the D. scoparium species complex with partially overlapping morphology and habitat ranges. This stu

Objectives Patients with type 2 diabetes mellitus (DM) run lower risk for abdominal aortic aneurysm (AAA, aortic diameter ≥ 30 mm) and its complications. We aimed to evaluate associations between disturbances in glucose metabolism and arterial stiffness, AAA, and abdominal aortic diameter in 65-year-old men. Methods Forty-eight 65-year-old men with screening-detected AAA and 115 men with normal ab

Satu Lähteenoja’s PhD thesis consists of five published articles and an extensive introduction. The articles make strong, or even major, contributions to research and Satu Lähteenoja’s contribution to the articles is clearly demonstrated. The introduction combines the articles into a whole and through the introduction the contribution is clearly bigger than the sum of the five articles.