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Petersén Å, Emgård M and Brundin P.Brain Research Bulletin 50: 275-281 (1999)AbstractThe survival of grafted embryonic striatal tissue, dissected from the lateral ganglionic eminence, depends on the status of the host striatum. We found significantly larger volumes of surviving graft tissue and of striatal-like tissue (P-zone) within the graft, when the host striatum had been subjected to an excit

https://www.huntington-research.lu.se/impact-preceding-excitotoxic-lesion-and-treatment-ciliary-neurotrophic-factor-striatal-graft - 2026-06-21

Petersén Å and Brundin P.Experimental Neurology 160: 402-412 (1999)AbstractCiliary neurotrophic factor (CNTF) has a protective effect on the striatum in animal models of Huntington's disease. However, the mechanism through which it exerts its effect is not clear. In this study, we show that there is a concentration-dependent direct protective effect of CNTF against N-methyl-D-aspartate-mediated ex

https://www.huntington-research.lu.se/effect-cntf-and-calcium-ionophore-a23187-induced-death-cultured-embryonic-stratal-neurons - 2026-06-21

Petersén Å, Mani K and Brundin P.Experimental Neurology 157: 1-18 (1999)AbstractWe review recent advances regarding the pathogenesis of Huntington's disease (HD). This genetic neurodegenerative disorder is caused by an expanded CAG repeat in a gene coding for a protein, with unknown function, called huntingtin. There is selective death of striatal and cortical neurons. Both in patients and a trans

https://www.huntington-research.lu.se/recent-advances-pathogenesis-huntingtons-disease - 2026-06-21

Baldo B, Gabery S, Soylu-Kucharz R, Cheong RY, Henningsen JB, Englund E, McLean C, Kirik D, Halliday G and Petersén Å.Neuropathology and Applied Neurobiology 45 (4): 361-379 (2019)AbstractAIMS:Metabolic dysfunction is involved in modulating the disease process in Huntington disease (HD) but the underlying mechanisms are not known. The aim of this study was to investigate if the metabolic regulator

https://www.huntington-research.lu.se/sirt1-increased-affected-brain-regions-and-hypothalamic-metabolic-pathways-are-altered-huntington - 2026-06-21

Brundin P, Petersén Å and Hansson O.Journal of Neurosurgery 90: 804-806 (1999)No abstract available; this is a letter to the editor.The letter 

https://www.huntington-research.lu.se/graft-survival - 2026-06-21

Pircs K, Petri R, Madsen S, Brattås PL, Vuono R, Ottosson DR, St-Amour I, Hersbach BA, Matusiak-Brückner M, Lundh SH, Petersén Å, Déglon N, Hébert SS, Parmar M, Barker RA and Jakobsson J.Cell Reports 24(6): 1397-1406 (2018)AbstractMany neurodegenerative diseases are characterized by the presence of intracellular protein aggregates, resulting in alterations in autophagy. However, the consequences o

https://www.huntington-research.lu.se/huntingtin-aggregation-impairs-autophagy-leading-argonaute-2-accumulation-and-global-microrna - 2026-06-21

Fjalldal S, Follin C, Svärd D, Rylander L, Gabery S, Petersen Å, Van Westen D, Sundgren P, Bjorkman-Burtscher I, Lätt J, Ekman B, Johanson A and Erfurth EM.European Journal of Endocrinology 178 (6): 577-587 (2018)AbstractCONTEXT:Patients with craniopharyngioma (CP) and hypothalamic lesions (HL) have cognitive deficits. Which neural pathways are affected is unknown.OBJECTIVE:To determine whether th

https://www.huntington-research.lu.se/microstructural-white-matter-alterations-and-hippocampal-volumes-are-associated-cognitive-deficits - 2026-06-21

Gawlik KI1, Harandi VM2, Cheong RY3, Petersén Å3, Durbeej M2.1Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.2Muscle Biology Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.3Translational Neuroendocrine Research Unit, Department of Experimental Medical Science, Lund University, Lund, Sweden.Matrix Biology 70: 36-79 (20

https://www.huntington-research.lu.se/laminin-a1-reduces-muscular-dystrophy-dy2j-mice - 2026-06-21

Vercruysse P, Vieau D, Blum D, Petersén Å and Dupuis L.Frontiers in Molecular Neuroscience 11:2 (2018)AbstractNeurodegenerative diseases (NDDs) are disorders characterized by progressive deterioration of brain structure and function. Selective neuronal populations are affected leading to symptoms which are prominently motor in amyotrophic lateral sclerosis (ALS) or Huntington's disease (HD), or co

https://www.huntington-research.lu.se/hypothalamic-alterations-neurodegenerative-diseases-and-their-relation-abnormal-energy-metabolism - 2026-06-21

Please note, that all links on this page open a new webpage. Knut and Alice Wallenberg FoundationThrough the research program Wallenberg Clinical Scholars, the Knut and Alice Wallenberg Foundation are funding 24 of the foremost clinical researchers in Sweden. Almost SEK 800 million are used for funding over ten years. Åsa Petersén was appointed Wallenberg Clinical Scholar 2020 and will receive SEK

https://www.huntington-research.lu.se/funding - 2026-06-21

CoordinatorAngela Cenci NilssonProfessor, Department of Experimental Medical ScienceVice CoordinatorMaria H NilssonProfessor, Department of Health Sciences, LundThe position is a joint position: Memory Clinic, Malmö, Skåne University HospitalVice CoordinatorPer OdinProfessor, Department of Clinical Sciences, LundScientific CommunicatorMartina SvenssonResearch AdministratorDiana JermanInfrastructue

https://www.multipark.lu.se/management - 2026-06-21

MultiPark and Clinical Studies Sweden – Forum South, Medical Statistics and Epidemiology Unit have entered into an agreement for ongoing project support. Scientists linked to MultiPark can now turn to Medical Statistics and Epidemiology Unit for help with study design, randomization, selection of appropriate statistical analysis, implementation of analysis, reporting and interpretation of results

https://www.multipark.lu.se/infrastructures/statistical-support - 2026-06-21

This group focuses on developing new imaging-based biomarkers for monitoring the early phases of neurodegenerative processes and, potentially, the response to disease-modifying treatments. We combine multiple modalities, including MRI, PET, fluid-based markers and genetics, to clarify the biological processes leading to neurodegenerative conditions. Additionally, we leverage data from deeply pheno

https://www.multipark.lu.se/development-and-application-novel-imaging-methods-observational-studies-and-clinical-trials - 2026-06-21

The drug candidate screening platform support researchers to identify and develop novel chemical tools to help you interrogate your particular field of interest. We contribute with +30 years of combined experiences from the pharmaceutical industry.Services providedConsultations within medicinal chemistry, chemical biology and drug discovery and developmentSmall molecule screening - assay developme

https://www.multipark.lu.se/infrastructures/drug-candidate-screening-platform - 2026-06-21

This group brings together researchers who want to use modern visualising methods to investigate molecular mechanisms at the sub-cellular level in neurodegenerative disorders. This includes, for example, high resolution, sub-cellular x-ray measurements to study molecular changes in cells or tissues to help identify the causes of the neurodegenerative diseases. Sweden has made significant strategic

https://www.multipark.lu.se/maxiv-sub-cellular-x-ray - 2026-06-21

Two-photon microscopy is the method of choice for imaging living cells and tissues (intravital microscopy). It allows imaging with very high temporal and spatial resolution in thick biological material. This MultiPark platform consists of two microscopy stations that serve different needs. The ‘in vivo’ setup can be used to image the processes in the living mouse, i.e. superficial layers of the ce

https://www.multipark.lu.se/infrastructures/two-photon-microscopy - 2026-06-21

Page under construction. Contact

https://www.multipark.lu.se/light-sheet-microscope - 2026-06-21

The Faculty of Medicine research and travel grantsTwo calls per year, see deadlines for submission on their website.The Swedish Parkinson FoundationTwo calls per year, see deadlines for submission on their website.The Royal Physiographic Society in LundSee deadlines for submission on their website.Wenner-Gren StiftelsernaTwo calls per year, see deadlines for submission on their website.Search for

https://www.multipark.lu.se/other-sources-funding-travel-grants - 2026-06-21

Our overarching research goal is to create new and innovative strategies for improved and novel treatments, disease modifications and eventually cures for neurodegenerative diseases. We are striving to understand the mechanisms of neurodegenerative diseases, and to create a dynamic structure for the advancement of research, innovation and education in the field. Ultimately, our research will impro

https://www.multipark.lu.se/research - 2026-06-21

Welcome to the Microscopy Platform! This platform consists of four systems under one umbrella platform.Below is an overview of the systems included in this platform as well as links to their webpages with more information:SystemTarget purposeLocationImaris SingleFull with Clearview version 10.2 (Workstation)3D/4D image visualization and analysisBMC B1155Leica SP8 laser scanning confocal microscope

https://www.multipark.lu.se/infrastructures/microscopy-platform - 2026-06-21