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Bergh S, Casadei N, Gabery S, Simonsson O,  Duarte JMN, Kirik D, Nguyen HP and Petersén Å.Acta Neuropathologica Communications. 2025;13(1):119. Published 2025 May 27. doi:10.1186/s40478-025-02018-8AbstractTAR DNA-binding protein 43 (TDP-43) pathology is linked to the neurodegenerative disorders amyotrophic lateral sclerosis (ALS), frontotemporal dementia (FTD) and Huntington disease (HD). Dysregul

https://www.huntington-research.lu.se/tdp-43-overexpression-hypothalamus-drives-neuropathology-dysregulates-metabolism-and-impairs - 2026-04-23

Li X, Li S, Li X-J, Nguyen HP, Petersen Å and Pouladi MA.Journal of Huntington’s Disease. 2025;14(3):270-278. doi: 10.1177/18796397251358017. AbstractHuntington's disease (HD) is a fatal neurodegenerative disorder characterized by progressive motor, cognitive, and psychiatric symptoms. Research efforts to understand and treat the disease have historically focused on neuronal pathology, but growing

https://www.huntington-research.lu.se/role-oligodendroglial-dysfunction-huntingtons-disease - 2026-04-23

Pouladi MA and Petersen A.Journal of Huntington’s Disease. 2025;14(3):212-213. doi: 10.1177/18796397251358289.No abstract available.Full text article - on Sage Journal's webpage (opens in a new window)

https://www.huntington-research.lu.se/special-issue-glia-and-non-neuronal-cells-huntingtons-disease - 2026-04-23

Gabery S, Sajjad MU, Hult S, Soylu R, Kirik D and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.Brain Repair and Imaging in Neural Systems (B.R.A.I.N.S.) Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.European Journal of Neuroscience 36(6):2789-800 (2012)AbstractHuntington's diseas

https://www.huntington-research.lu.se/characterization-rat-model-huntingtons-disease-based-targeted-expression-mutant-huntingtin-forebrain - 2026-04-23

A new paper from TNU has been published, shedding light on the key role of TDP-43 in the hypothalamus in models of neurodegenerative disorders, including amyotrophic lateral sclerosis, frontotemporal dementia, and Huntington's disease. The paper was published with international collaborators in Acta Neuropathologica Communications on May 27, 2025Full text article on BMC:s webpage (opens in a new w

https://www.huntington-research.lu.se/paper-tdp-43-key-roll-hypothalamus - 2026-04-23

Oraha J, Wagner R, Bergh S, Lee NJ, Kirik D and Petersén Å.Acta  Neuropathologica Communications. 2025 Dec 7. doi: 10.1186/s40478-025-02201-x. Online ahead of print.PMID: 41354852.AbstractThe spectrum of frontotemporal dementia/amyotrophic lateral sclerosis (FTD/ALS) and Huntington disease (HD) are fatal neurodegenerative disorders with no major disease-modifying therapies. Recent work has shown t

https://www.huntington-research.lu.se/differential-effects-overexpression-mutant-huntingtin-and-tdp-43-agouti-related-protein-neurons - 2026-04-23

Petersen Å and Gabery S.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund, Sweden.Journal of Huntington's disease 1: 13-24 (2012)AbstractHuntington’s disease (HD) is a neurodegenerative disorder caused by an expanded CAG repeat in the huntingtin gene. Today, the clinical diagnosis of the disease requires unequivocal signs of typical moto

https://www.huntington-research.lu.se/hypothalamic-and-limbic-system-changes-huntingtons-disease - 2026-04-23

Aziz NA, Claassen D, Petersén Å and Weydt P.European Huntington's Disease Network and the Huntington Study Group. Published online December 15, 2025. doi:10.1177/18796397251401745AbstractA recent retrospective analysis of Enroll HD data suggesting β-blockers slow Huntington's disease progression has triggered patient demand but requires caution. The findings rely solely on small observational subs

https://www.huntington-research.lu.se/b-blocker-effects-huntingtons-disease-caution-clinical-interpretation - 2026-04-23

Bergh S, Simonsson O and Petersén Å.Neuropathology and Applied Neurobiology 52(1):e70059 (2026)AbstractSelective TDP-43 overexpression in oxytocin neurons in the paraventricular nucleus of the hypothalamus causes a decrease in oxytocin-immunopositive cells compared to uninjected mice. AAV-mediated TDP-43 overexpression in oxytocin neurons does not appear to be a major driver of behavioural and met

https://www.huntington-research.lu.se/analyses-effects-wild-type-tdp-43-overexpression-oxytocin-neurons-mice - 2026-04-23

Gabery S, Bergh S, Huridou C, Cheong RY, Baldo B, Scheunemann PG, Schoebel M-L, Holmquist Mengelbier L, Englund E, McLean C, Saft C, Kirik D, Björkqvist M, Halliday G, Petrasch-Parwez E, Nguyen HP, Weber JJ and Petersén Å.Brain Pathology. 2026;e70088. Published 24 February 2026. doi.org/10.1111/bpa.70088.AbstractThe pathogenic mechanisms leading to neurodegeneration in Huntington disease (HD) are

https://www.huntington-research.lu.se/dnarna-autophagy-protein-sidt2-novel-neuropathological-hallmark-huntington-disease - 2026-04-23

Dupuis L1, 2, 3, Petersen A4, Weydt P31 Inserm U692, Laboratoire de Signalisations Moléculaires et Neurodégénérescence, 67085Strasbourg, France2 Université de Strasbourg, Faculté de Médecine, UMRS692, 67085Strasbourg, France3 Department of Neurology, Ulm University, 89081 Ulm, Germany4 Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, 22184Lu

https://www.huntington-research.lu.se/progranulin-bridges-energy-homeostasis-and-fronto-temporal-dementia - 2026-04-23

Hult S*, Soylu R*, Björklund T, Belgardt B F, Mauer J, Brüning J C, Kirik D and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund 22184, Sweden.Cell Metabolism 13: 428-439 (2011) *equal contributionAbstractIn Huntington's disease (HD), the mutant huntingtin protein is ubiquitously expressed. The disease was considered to be li

https://www.huntington-research.lu.se/mutant-huntingtin-causes-metabolic-imbalance-disruption-hypothalamic-neurocircuits - 2026-04-23

Piguet O, Petersén A, Yin Ka Lam B, Gabery S, Murphy K, Hodges JR and Halliday GM.Neuroscience Research Australia, Sydney, Australia.Annals of Neurology 69: 312-319 (2011)AbstractOBJECTIVE: Behavioral-variant frontotemporal dementia (bvFTD) is a progressive neurodegenerative brain disorder, clinically characterized by changes in cognition, personality, and behavior. Marked disturbances in eating b

https://www.huntington-research.lu.se/eating-and-hypothalamus-changes-behavioral-variant-frontotemporal-dementia - 2026-04-23

2026Gabery S, Bergh S, Huridou C, Cheong RY, Baldo B, Scheunemann PG, Schoebel M-L, Holmquist Mengelbier L, Englund E, McLean C, Saft C, Kirik D, Björkqvist M, Halliday G, Petrasch-Parwez E, Nguyen HP, Weber JJ and Petersén Å.The DNA/RNA autophagy protein SIDT2 as a novel neuropathological hallmark in Huntington disease.Brain Pathology. 2026;e70088. Published 24 February 2026. doi.org/10.1111/bpa.

https://www.huntington-research.lu.se/publications - 2026-04-23

Mikrouli E, Wörtwein G, Soylu R, Mathé AA and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, Lund 22184, Sweden.Neuropeptides 45(6): 401-406 (2011)AbstractThe Flinders Sensitive Line (FSL) rat is a genetic animal model of depression that displays characteristics similar to those of depressed patients including lower body weight,

https://www.huntington-research.lu.se/increased-numbers-orexinhypocretin-neurons-genetic-rat-depression-model - 2026-04-23

Gil-Mohapel J, Brocardo PS, Smith R, Lagerkvist S, Li JY and Petersén Å.In H.T. Maldonado and I.M. Ortega (Eds.) Striatum: Anatomy, Functions and Role in Disease. New York, USA: Nova Publishers.AbstractBackground: Huntington’s disease (HD) is the most common polyglutamine neurodegenerative disorder. The mutation consists of an unstable expansion of CAG repeats within the coding region of the HD ge

https://www.huntington-research.lu.se/impaired-nigrostriatal-dopaminergic-neurotransmission-huntingtons-disease-insights-r61-transgenic - 2026-04-23

Petersén Å.Department of Experimental Medical Science, Translational Neuroendocrine Research Unit, Lund University, Lund, Sweden.European Neurological Review 5: 49–53 (2010)AbstractHuntington’s disease (HD) is a hereditary neurodegenerative disorder that leads to premature death. There is no satisfactory treatment or cure. The disease is caused by an expanded CAG repeat in the huntingtin gene. The

https://www.huntington-research.lu.se/role-hypothalamic-and-neuroendocrine-changes-pathogenesis-huntingtons-disease-current-understanding - 2026-04-23

Gabery S, Murphy K, Schultz K, Loy CT, McCusker E, Kirik D, Halliday G and Petersén Å.Translational Neuroendocrine Research Unit, Department of Experimental Medical Sciences, Lund University, BMC D11, 221 84, Lund, Sweden.Acta Neuropathologica 120: 777-788 (2010)AbstractHuntington disease (HD) is a fatal neurodegenerative disorder caused by expansion of a CAG repeat in the HD gene. Degeneration co

https://www.huntington-research.lu.se/changes-key-hypothalamic-neuropeptide-populations-huntington-disease-revealed-neuropathological - 2026-04-23

Braunstein KE, Eschbach J, Ròna-Vörös K, Soylu R, Mikrouli E, Larmet Y, Rene F, Gonzalez de Aguilar JL, Loeffler JP, Müller HP, Bucher S, Kaulisch T, Niessen HG, Tillmanns J, Fischer K, Schwalenstocker B, Kassubek J, Pichler B, Stiller D, Petersen A, Ludolph AC and Dupuis L.Department of Neurology, University of Ulm, Ulm, Germany.Human Molecular Genetics 19: 4385-4398 (2010)AbstractThe molecular m

https://www.huntington-research.lu.se/point-mutation-dynein-heavy-chain-gene-leads-striatal-atrophy-and-compromises-neurite-outgrowth - 2026-04-23

Soneson C, Fontes M, Zhou Y, Denisov V, Paulsen JS, Kirik D and Petersén A; The Huntington Study Group PREDICT-HD investigators.Centre for Mathematical Sciences, Lund University, Sweden; Brain Repair and Imaging in Neural Systems, Department of Experimental Medical Science, BMC D11, Lund University, Sweden; Lund University Bioimaging Center, Lund University, Sweden.Neurobiology of Disease 40: 531-

https://www.huntington-research.lu.se/early-changes-hypothalamic-region-prodromal-huntington-disease-revealed-mri-analysis - 2026-04-23