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The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide, 1, has previously been identified as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3). Herein we describe synthesis and evaluation of 55 compounds in this class. It was found that the stereochemistry is of great importance for both selectivity and potency and that subs

Senior lecturer The aim of my research is to understand how our home galaxy, the Milky Way, and its stellar populations formed and evolved to what we observe today. There are many pieces in the puzzle and I focus on the observational ones, mapping the detailed structure in terms of abundances, kinematics, and ages, using high-resolution spectra obtained with the large optical telescopes around the

https://www.astro.lu.se/~tbensby - 2026-05-03

Director of graduate studies Contact details Email: thomas [dot] bensby [at] fysik [dot] lu [dot] se Phone: +46 46 222 73 24Organisation Astrophysics Room number: A427 Service point: 14 WebpageThomas Bensbys profile in Lund University research portalOther affiliations Health and safety representative Astrophysics Director of third cycle studies Department of Physics Publications Displaying of publ

https://www.fysik.lu.se/en/thomas-bensby - 2026-05-03

Rights in Russia - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation of Programme Work Methods

https://rwi.lu.se/blog/rights-in-russia/ - 2026-05-03

Kurslitteratur MVEN16_HT19_16okt19 Kurslitteratur MVEN16 2019-10-16 MVEN16 KURSLITTERATUR, HT19 OBS! Vissa artiklar kan ändras/tillkomma under kursens gång! Kursböcker Boyce, T. and Lewis, J., eds. (2009). Climate Change and the Media. Global Crises and the Media Series. Peter Lang Pub Inc. (OBS! om svårtillgänglig, tillhandahålles utvalda kapitel under kursens gång) Bulkeley, H. and Newell, P. (2

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/kurslitteratur_mven16_ht19_16okt19.pdf - 2026-05-03

This paper describes the active burst distance for convolutional codes. The unequal error protection for information sequences are used to formulate a theorem on the error-correcting capability of the generator matrix and set state paths in the encoder state-transition diagram correspond to code sequences. Therefore the active-distance concepts are used to characterize the error patterns

Mitochondrial abnormalities may be involved in PTSD, although few studies have examined this. Mitochondrial DNA copy number (mtDNAcn) in blood cells is an emerging systemic index of mitochondrial biogenesis and function. The present study assessed mtDNAcn in male combat-exposed veterans with PTSD compared to those without PTSD as well as its correlation with clinical scales.

Background: The dry transitional forests of the southern Amazonia have received little attention from a carbon cycling and ecosystem function perspective, yet they represent ecosystems that may be impacted by global climate change in the future. Aims: To compare the full carbon cycle for two 1-ha forest plots that straddle the ecotone between humid forest and dry forest in Amazonia, ca. 100 km fro

Background: Although avian Plasmodium species are widespread and common across the globe, limited data exist on how genetically variable their populations are. Here, the hypothesis that the avian blood parasite Plasmodium relictum exhibits very low genetic diversity in its Western Palearctic transmission area (from Morocco to Sweden in the north and Transcaucasia in the east) was tested. Methods:

Familial myelodysplastic syndromes arise from haploinsufficiency of genes involved in hematopoiesis and are primarily associated with early-onset disease. Here we describe a familial syndrome in seven patients from four unrelated pedigrees presenting with myelodysplastic syndrome and loss of chromosome 7/7q. Their median age at diagnosis was 2.1 years (range, 1-42). All patients presented with thr

INTRODUCTION: Recently, an increasing number of tau tracers have become available. There is a need to standardize quantitative tau measures across tracers, supporting a universal scale. We developed several cortical tau masks and applied them to generate a tau imaging universal scale. METHOD: One thousand forty-five participants underwent tau scans with either 18F-flortaucipir, 18F-MK6240, 18F-PI2

Multiple guidelines exist for the management of aortic stenosis (AS). We systematically reviewed current guidelines and recommendations, developed by national or international medical organizations, on management of AS to aid clinical decision-making. Publications in MEDLINE and EMBASE between 1 June 2010 and 15 January 2021 were identified. Additionally, the International Guideline Library, Natio

The use of daratumumab in combination with established regimens for the treatment of newly diagnosed multiple myeloma has recently been authorized by the European Medicines Agency based on results from three separate phase III randomized, active controlled, open-label studies that have confirmed enhanced efficacy and tolerability in both transplant-ineligible (MMY3008 and MMY3007) and transplant-e

This thesis treats the intersection between two of the largest transformations we are seeing within our society today; the cloud and the Internet-of-Things (IoT). The aim of this thesis is to investigate different ways to model and control a network of cloud services so that timing-critical IoT applications can make use of them. Examples of such applications can be autonomous and mobile robots, sm

In the recent project BENCHOP–the BENCHmarking project in Option Pricing we found that Stochastic and Local Volatility problems were particularly challenging. Here we continue the effort by introducing a set of benchmark problems for this type of problems. Eight different methods targeted for the Stochastic Differential Equation (SDE) formulation and the Partial Differential Equation (PDE) formula

Tumor-associated macrophages (TAMs) are attractive targets for immunotherapy. Recently, studies in animal models showed that treatment with an anti-TAM antibody directed against the scavenger receptor MARCO resulted in suppression of tumor growth and metastatic dissemination. Here we investigated the expression of MARCO in relation to other macrophage markers and immune pathways in a non-small cel

We describe an entomological dual-band 808 and 980 nm lidar system which has been implemented in a tropical cloud forest (Ecuador). The system was successfully tested at a sample rate of 5 kHz in a cloud forest during challenging foggy conditions (extinction coefficients up to 20 km–1). At times, the backscattered signal could be retrieved from a distance of 2.929 km. We present insect and bat obs

Aim: The treatment of peritoneal surface malignancies ranges from palliative care to full cytoreductive surgery (CRS) and heated intraperitoneal chemotherapy, HIPEC. Ongoing monitoring of patient recruitment and volume is usually carried out through dedicated registries. With multiple registries available worldwide, we sought to investigate the nature, extent and value of existing worldwide CRS an

Posttraumatic stress disorder (PTSD) is associated with increased risk for Type 2 diabetes and cardiovascular disease (cardiometabolic disease), warranting research into targeted prevention strategies. In the present case–control study of 160 young (mean age 32.7 years) male military veterans, we aimed to assess whether PTSD status predicted increased markers of cardiometabolic risk in otherwise h

5G promises to usher in the industrial 4.0 era. In that era, intricately managed autonomous industrial sites with for example remotely controller equipment and autonomous units promise previously unseen levels of efficiency. Although such scenarios are elusive, they come with strict long-since established safety requirements. To uphold such requirements, intelligent industrial 5G networks, that ac