Filetype
Metal affinity tags have been fused to proteins and demonstrated to function as tools in protein purification, protein stabilisation, quantitative metal analysis and metal tolerance of bacteria and plants. In biotechnological applications proteins frequently have to function in nonnatural environments with harsh conditions which impose requirements for high stability on the proteins. Metal affini
NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly fac
Background Oxidative stress is implicated in both depression and anxiety, but it is currently unclear whether this relates to syndromal diagnoses or trans-diagnostic dimensional symptoms. We examined the relationship between oxidative stress and severity of depression and anxiety symptoms in individuals with Major Depressive Disorder (MDD). Methods Plasma oxidative stress markers F2-isoprostanes a
Mammographic sensitivity in breasts with higher density has been questioned. Higher breast density is also linked to an increased risk for breast cancer. Even though digital breast tomosynthesis (DBT) offers an attractive solution, for varied reasons it has not yet been widely adopted in screening. An alternative could be to boost the performance of standard mammography by using computer-aided det
Breast cancer screening is predominantly performed using digital mammography (DM), but higher sensitivity has been demonstrated with digital breast tomosynthesis (DBT). A partial DBT screening in selected groups with a clear benefit from DBT might be more feasible than a full implementation, and using artificial intelligence (AI) to select women for DBT might be a possibility. This study used data
Numerical weather prediction models are increasing in resolution and becoming capable of explicitly representing individual convective storms, but we do not yet know if it is the improved resolution that is leading to better forecasts.
Colony stimulating factor 1 receptor (CSF1R)-related leukoencephalopathy is a rare, genetic disease caused by heterozygous mutations in the CSF1R gene with rapidly progressive neurodegeneration, behavioral, cognitive, motor disturbances. Objective: To describe four cases of CSF1R-related leukoencephalopathy from three families with two different pathogenic mutations in the tyrosine kinase domain o
Purpose: Validation of artificial intelligence (AI) algorithms in digital pathology with a reference standard is necessary before widespread clinical use, but few examples focus on creating a reference standard based on pathologist annotations. This work assesses the results of a pilot study that collects density estimates of stromal tumor-infiltrating lymphocytes (sTILs) in breast cancer biopsy s
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the IN
A grazing-incidence Rowland spectrometer with a collimating element for resonant inelastic soft X-ray scattering at the Veritas beamline at MAX IV, Lund, Sweden, is presented. The instrument is designed to operate in the 250–950 eV range, providing >30000 resolving power in first order. The inherent temporal resolution of the delay-line detector enables time-resolved experiments on the 270 ps time
ObjectivesTransdiagnostic models aim to uncover shared mechanisms across mental disorders. Reward responsiveness (the ability to experience pleasure from rewarding stimuli) is a plausible, yet underexplored, transdiagnostic mechanism linking obsessive-compulsive disorder (OCD) and depression. This study used network analysis to (1) examine how key reward responsiveness domains are interlinked in i
OBJECTIVES: Digital breast tomosynthesis (DBT) can detect more cancers than the current standard breast screening method, digital mammography (DM); however, it can substantially increase the reading workload and thus hinder implementation in screening. Artificial intelligence (AI) might be a solution. The aim of this study was to retrospectively test different ways of using AI in a screening workf
BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movemen
Objectives: To analyze device designs, similarities and overlaps of custom-made fenestrated arch endografts intended for mid/distal arch thoracic endovascular aortic repair. Materials and Methods: A multicenter cross-sectional study analyzing custom-made anonymized graft plans was performed. Graft plans were included from a cohort of mid/distal aortic arch repairs using custom-made fenestrated aor
Interference between scattering channels is observed in resonant inelastic x-ray scattering (RIXS) at the Ne K threshold. Final states with |2p-1np⟩ as the main configuration are populated via |1s-1n′p⟩ resonances, where large-amplitude one-electron (n′=n) channels interfere with small-amplitude two-electron (n′≠n) channels. The interference is manifested in an asymmetric line profile where the tw
The racemic 3-(4-oxo-3,4-dihydroquinazolin-2-yl)-N-[1-(pyridin-2-yl)ethyl]propanamide, 1, has previously been identified as a potent but unselective inhibitor of diphtheria toxin-like ADP-ribosyltransferase 3 (ARTD3). Herein we describe synthesis and evaluation of 55 compounds in this class. It was found that the stereochemistry is of great importance for both selectivity and potency and that subs
Beräkningsmodelleringar har blivit ett allt mer viktigt verktyg inom biologisk forskning. Genom att utföra datorsimuleringar av modeller blir det möjligt att testa hur teorier om biologiska system förhåller sig till experimentell data. Simuleringar kan även användes som ersättning för potentiellt ogenomförbara experiment. En välkonstruerade modells förmåga att göra förutsägelser kan hjälpa till atComputational modelling is becoming an increasingly important tool in biological research. By performing computer simulations of models, it becomes possible to test theories about a biological system against experimental data. Simulations can also be used as a replacement for experiments otherwise unattainable. Well-constructed models have great predictive power which helps improve experimental pr
Licentiatrutiner 2014 Postadress Box 192, 221 00 Lund Besöksadress Helgonavägen 3, hus B Telefon dir 046-222 83 15, växel 046-222 00 00 Telefax 046-222 32 28 E-post jesper.olsson@kansliht.lu.se Internet http://www.ht.lu.se Kans l i HT Fakul tetskoord inator Jesper Olsson Inför licentiatseminarium Detta dokument avser att underlätta de administrativa rutinerna i samband med licentiatseminarium. Det
https://www.ht.lu.se/fileadmin/user_upload/ht/dokument/Utbildning/doktorand/Licentiatrutiner_20141020.pdf - 2026-07-11
HILMA 2010-11-11 HILMA Historiska Institutionen i Lund Meddelar Att… Årgång 36, 2010/11, Nr 3, 2010-11-11 Underlagen till HILMA förvaras i pärmar som står i rum 209, på hyllan ovanför faxen. Där hittar du ytterligare information om seminarier, anställningsvillkor, stipendier och annat samt ansök- ningsblanketter i förekommande fall. De sistnämnda, som är samlade i en separat pärm, kopierar du och
https://www.hist.lu.se/fileadmin/_migrated/content_uploads/hilma_ht10_2_03.pdf - 2026-07-11
