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Over recent decades, management of people with hemophilia (PwH) has been greatly improved by scientific advances that have resulted in a rich and varied therapeutic landscape. Nevertheless, treatment limitations continue to drive innovation, and emerging options have the potential to realize further improvement. We advocate four general principles to optimize benefits from innovation: individualiz
The dynamics of chemical reactions in solution are of paramount importance in fields ranging from biology to materials science. Because the hydrogen-bond network and proton dynamics govern the behavior of aqueous solutions, they have been the subject of numerous studies over the years. Here, we report the observation of a previously unknown associative state in the hydroxide ion that forms when a
Context. The coupling between the dark matter (DM) halo and the stellar disc is a key factor in galactic evolution. While the interaction between structures like the Galactic bar and DM halos has been explored (e.g. slowing down of the bar due to dynamical friction), the effect of spiral arms on the DM halo distribution has received limited attention. Aims. We aim to detect and characterize the in
Disease-modifying therapies (DMTs) for multiple sclerosis (MS) can increase the risk of hepatitis B virus (HBV) reactivation (HBr), particularly with agents like ocrelizumab and alemtuzumab. However, studies in MS patients treated with DMTs indicate significantly lower reactivation rates compared to those with hematologic malignancies. This review discusses strategies for managing HBV in MS patien
Early recognition and management of sports-related concussion (SRC), including removal from the sports activity, is essential for player safety and to prevent long-term symptoms. A graduated, stepwise rehabilitation protocol is implemented to allow the athlete to return to sports. In 2022, the 6th international consensus statement on concussion in sports was presented, which has now been adapted t
Språk- och litteraturcentrum Kinesiska 2 LITTERATURLISTA OSHA01, KINAS HISTORIA (15 hp) History of China (15 credits) Fastställd av styrelsen för Sektion 6 2025-12-04 Obligatorisk litteratur Fairbank, John King & Goldman, Merle (2006). China: a new history. Cambridge, MA: Belknap Press of Harvard University Press, 640 s. Fewsmith, Joseph. (2012). “Introduction,” China since Tiananmen: From Deng Xi
https://www.sol.lu.se/media/utbildning/dokument/kurser/OSHA01/20261/OSHA01Litteraturlista_VT2026.docx - 2026-07-11
Projektansökan ÅRSBERÄTTELSE FÖR FORSKARSKOLAN I HISTORIA LÄSÅRET 2001—2002 Denna årsberättelse för forskarskolans första verksamhetsår redogör också för uppbyggnadsskedet. Forskarskolans tillblivelse Forskarskolan i historia inrättades genom riksdagsbeslut hösten 2000. I det årets budgetproposition lanserade regeringen en satsning på 16 nya forskarskolor. Bland dessa intog forskarskolan i histori
Chronic inflammation may be involved in combat-related post-traumatic stress disorder (PTSD) and may help explain comorbid physical diseases. However, the extent to which combat exposure per se, depression, or early life trauma, all of which are associated with combat PTSD, may confound the relationship between PTSD and inflammation is unclear.
Background: In animal studies, perfluorinated alkyl substances affect growth and neuro-behavioural outcomes. Human epidemiological studies are sparse. The aim was to investigate the association between pregnancy serum concentrations of perfluorooctanoate (PFOA) and perfluorooctane sulfonate (PFOS) and offspring behaviour and motor development at 5-9 years of age. Methods: Maternal sera from the IN
Numerical weather prediction models are increasing in resolution and becoming capable of explicitly representing individual convective storms, but we do not yet know if it is the improved resolution that is leading to better forecasts.
Metal affinity tags have been fused to proteins and demonstrated to function as tools in protein purification, protein stabilisation, quantitative metal analysis and metal tolerance of bacteria and plants. In biotechnological applications proteins frequently have to function in nonnatural environments with harsh conditions which impose requirements for high stability on the proteins. Metal affini
A comprehensive study of the molecular active landscape of human cells can be undertaken to integrate two different but complementary perspectives: transcriptomics, and proteomics. After the genome era, proteomics has emerged as a powerful tool to simultaneously identify and characterize the compendium of thousands of different proteins active in a cell. Thus, the Chromosome-centric Human Proteome
Background Oxidative stress is implicated in both depression and anxiety, but it is currently unclear whether this relates to syndromal diagnoses or trans-diagnostic dimensional symptoms. We examined the relationship between oxidative stress and severity of depression and anxiety symptoms in individuals with Major Depressive Disorder (MDD). Methods Plasma oxidative stress markers F2-isoprostanes a
NETs (neutrophil extracellular traps) have been described as a fundamental innate immune defence mechanism. During formation of NETs, the nuclear membrane is disrupted by an as-yet unknown mechanism. In the present study we investigated the role of human cathelicidin LL-37 in nuclear membrane disruption and formation of NETs. Immunofluorescence microscopy revealed that 5 μM LL-37 significantly fac
BackgroundMajor depressive disorder (MDD) is associated with increased allostatic load (AL; a measure of physiological costs of repeated/chronic stress-responding) and metabolic dysregulation (MetD; a measure of metabolic health and precursor to many medical illnesses). Though AL and MetD are associated with poor somatic health outcomes, little is known regarding their relationship with antidepres
Purpose: Validation of artificial intelligence (AI) algorithms in digital pathology with a reference standard is necessary before widespread clinical use, but few examples focus on creating a reference standard based on pathologist annotations. This work assesses the results of a pilot study that collects density estimates of stromal tumor-infiltrating lymphocytes (sTILs) in breast cancer biopsy s
OBJECTIVES: Digital breast tomosynthesis (DBT) can detect more cancers than the current standard breast screening method, digital mammography (DM); however, it can substantially increase the reading workload and thus hinder implementation in screening. Artificial intelligence (AI) might be a solution. The aim of this study was to retrospectively test different ways of using AI in a screening workf
BACKGROUND: Movement disorders are frequent in patients with inborn errors of metabolism (IEMs) but poorly recognized, particularly by nonmovement disorder specialists. We propose an easy-to-use clinical screening tool to help recognize movement disorders.OBJECTIVE: The aim is to develop a user-friendly rapid screening tool for nonmovement disorder specialists to detect moderate and severe movemen
