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It is unclear whether the distribution of tau pathology differs between cases with early-onset familial Alzheimer's disease (AD) and sporadic AD. We present positron emission tomography (PET) data from a young patient with a presenilin-1 mutation (Thr116Asn). 18F-flutemetamol PET showed a distribution of amyloid-β fibrils similar to sporadic AD. However, the pattern of tau pathology, revealed usin

Improvements in colorectal cancer (CRC) detection and treatment have led to greater numbers of CRC survivors, for whom there is limited evidence on which to provide dietary guidelines to improve survival outcomes. Higher intake of red and processed meat and lower intake of fibre are associated with greater risk of developing CRC, but there is limited evidence regarding associations with survival a

Skin is attractive for drug therapy because it offers an easily accessible route without first-pass metabolism. Transdermal drug delivery is also associated with high patient compliance and through the site of application, the drug delivery can be locally directed. However, to succeed with transdermal drug delivery it is often required to overcome the low permeability of the upper layer of the ski

Purpose – The purpose of this paper is to analyze and contextualize the outcomes of competence development as a restructuring strategy in a company that was significantly affected by the economic recession in 2008. Design/methodology/approach – In the context of restructuring, increased globalization has expanded international competition that in turn has put additional pressure on organizational

Background: There is a lack of standardisation in quality of life (QoL) measurements to be used in older multimorbid patients. An ideal QoL measurement should be reliable, valid, subjective, multidimensional, feasible and generic. We hypothesised that the QoL-AD (Quality of Life in Alzheimer's Disease) scale could have these properties. Our aim was to determine the psychometric properties and clin

Background: In recent years, the medical curricula have become more crowded and the majority of medical students are no longer exposed to plastic surgery in medical school. Previous studies have revealed that most medical students are not aware of what the speciality entails.The aims of this paper were to describe the development of an elective course, as a method for including more plastic surger

Objective: Catheter-associated urinary tract infection (CAUTI) is the most common healthcare-associated infection. The primary aim of this study was to investigate whether the use of a silicone catheter coated with an ultrathin layer of a combination of the noble metals gold, palladium and silver (BIP™–silicone catheter) could reduce the incidence of CAUTI and antibiotic prescription compared with

Helicobacter pylori is an important human pathogen and a common cause of peptic ulcers and gastric cancer. Despite H. pylori provoking strong innate and adaptive immune responses, the bacterium is able to successfully establish long-term infections. Vitronectin (Vn), a component of both the extracellular matrix and plasma, is involved in many physiological processes, including regulation of the co

Flooding is the most common natural hazard in Europe. Cities cannot rely only on underground solutions which are expensive and inflexible. In order to reduce the negative impacts of flood, open and surface solutions play a key role in the efficiency of urban drainage systems. Utilizing the earth’s surface as part of sustainable water infrastructure, also as powerful element for creating the space,

A major issue in Irish economic history is the lack of historical national accounts before the interwar period. This paper addresses the gap with new annual estimates of real GDP between 1842 and 1913 using an indirect estimation technique based on a set of macroeconomic variables and a dynamic factor model. Three major results emerge from the data. First, per capita growth was faster in this peri

Background: Measurement of anti-Müllerian hormone (AMH) is a valuable clinical tool for evaluating ovarian function. The present study aims to evaluate the reliability of AMH measurements obtained from samples kept for long-term storage with or without intermittent thawing.Methods and findings: Serum samples from 35 young female cancer patients were prospectively collected and stored at -80°C from

Risks include the factors that might adversely affect project outcomes. Risk analysis includes the processes concerned with identifying, analyzing and developing security strategy and plans for the factors. Although currently there are known methodologies such as (CCTA Risk Analysis and Management Method (CRAMM) or Consultative, Objective and Bi-functional Risk Analysis(COBRA) and so on) for Risk

Recent developments in Knowledge Sharing (KS) have heightened the need for security. However, there has been little discussion about ‘how to’ integrate security into KS models effectively. This research addresses this gap by proposing a KS Risk Governance (KSRG) framework and research model based on the framework to integrate security into KS through Knowledge Risk Governance (KRG). The role of KR

One of the most significant current discussions in Knowledge Sharing (KS) is security. Security is an important component in KS, and plays a key role in reducing the risks in KS. However, relatively little study has been performed on KS security in the public and private sectors, and even less in the developing countries. This research intends to find the relationship between organizational contex